The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid β Protein Levels

2007 ◽  
Vol 2007 ◽  
pp. 22-23
Author(s):  
H.T. Lee
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Inhalation Anesthetic ◽  
Β Protein ◽  
The Common

scholarly journals The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β-protein level in vivo

2008 ◽  
Vol 64 (6) ◽  
pp. 618-627 ◽  
Author(s):  
Zhongcong Xie ◽  
Deborah J. Culley ◽  
Yuanlin Dong ◽  
Guohua Zhang ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Protein Level ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Caspase Activation ◽  
Inhalation Anesthetic ◽  
Β Protein ◽  
The Common

scholarly journals The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid β-Protein Levels under Hypoxic Conditions

2008 ◽  
Vol 283 (18) ◽  
pp. 11866-11875 ◽  
Author(s):  
Bin Zhang ◽  
Yuanlin Dong ◽  
Guohua Zhang ◽  
Robert D. Moir ◽  
Weiming Xia ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Caspase Activation ◽  
Protein Levels ◽  
Hypoxic Conditions ◽  
Inhalation Anesthetic ◽  
Β Protein

scholarly journals The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

2004 ◽  
Vol 279 (47) ◽  
pp. 49099-49104 ◽  
Author(s):  
Ju-Hyun Lee ◽  
Kwok-Fai Lau ◽  
Michael S. Perkinton ◽  
Claire L. Standen ◽  
Boris Rogelj ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Β ◽  
Adaptor Protein ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Β Protein

scholarly journals Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

2021 ◽  
Vol 12 (1) ◽  
pp. 301-308
Author(s):  
Yuqi Zeng ◽  
Yongkun Li ◽  
Hui Shen ◽  
Nan Lin ◽  
Jian Zhang
Keyword(s):  
Nitrosative Stress ◽  
Amyloid Β ◽  
Inflammatory Factors ◽  
Amyloid Β Protein ◽  
Neuroprotective Effects ◽  
Western Blots ◽  
Protein Levels ◽  
Cell Vitality ◽  
Β Protein ◽  
Aβ Generation

Abstract Background and purpose Alzheimer’s disease (AD) is a neurodegeneration disease. The previous work from our research group demonstrated the neuroprotective effects of tripchlorolide (T4) in AD animal models. Materials and methods Neprilysin (NEP) is known as an important physiological amyloid-β protein (Aβ) peptide-degrading enzyme in the brain due to its apparent rate-limiting function. In this study, we explored the effect of NEP on AD model N2a/APP695 cells. Western blots and enzyme-linked immunosorbent assays were performed to assess the expression of proteins, while quantitative real-time polymerase chain reaction assays were used to evaluate RNA levels. Cell vitality was detected by the MTT assay, and reactive oxygen species (ROS) levels were assessed using a ROS activity assay kit. Results We discovered that T4 was able to enhance the enzyme activity of NEP. T4 administration decreased the protein levels of the soluble amyloid precursor protein. In further experiments, we found that by using thiorphan the secretion of Aβ, oxidative stress, nitrosative stress, and inflammatory factors, which were suppressed by T4, were reversed. Due to its ability to attenuate Aβ generation and to protect neurons against the neurotoxicity of Aβ, T4 may be a potential therapy in the regulation of Aβ-related pathology in AD by affecting NEP activity. Conclusion Tripchlorolide attenuates Aβ generation by inducing NEP activity in N2a/APP695 cells.

scholarly journals Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels

2003 ◽  
Vol 60 (7) ◽  
pp. 958 ◽  
Author(s):  
Hiroaki Fukumoto ◽  
Marsha Tennis ◽  
Joseph J. Locascio ◽  
Bradley T. Hyman ◽  
John H. Growdon ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Β Protein

Luteinizing Hormone Levels Are Positively Correlated with Plasma Amyloid-β Protein Levels in Elderly Men

2008 ◽  
Vol 14 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Giuseppe Verdile ◽  
Bu B. Yeap ◽  
Roger M. Clarnette ◽  
Satvinder Dhaliwal ◽  
Melanie S. Burkhardt ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Elderly Men ◽  
Hormone Levels ◽  
Protein Levels ◽  
Β Protein
Sign in / Sign up

Export Citation Format

Share Document