Can the core length involved with prostate cancer identify clinically insignificant disease in low risk patients diagnosed on the basis of a single positive core?

2003 ◽  
Vol 21 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Andrew K. Lee ◽  
Tatiana Doytchinova ◽  
Ming-Hui Chen ◽  
Andrew A. Renshaw ◽  
Michael Weinstein ◽  
...  

2013 ◽  
Vol 39 (6) ◽  
pp. 800-807 ◽  
Author(s):  
Ricardo Kupka da Silva ◽  
Marcos Francisco Dall'oglio ◽  
Alexandre Crippa Sant'ana ◽  
Jose Pontes Junior ◽  
Miguel Srougi


2018 ◽  
Vol 50 (10) ◽  
pp. 1829-1833
Author(s):  
Hayato Yamamoto ◽  
Takuya Koie ◽  
Teppei Ookubo ◽  
Koji Mitsuzuka ◽  
Shintaro Narita ◽  
...  


2006 ◽  
Vol 175 (4S) ◽  
pp. 507-507 ◽  
Author(s):  
Theodore Barber ◽  
Vaishali Pansare ◽  
Dimitriy Nikolavsky ◽  
J. Edson Pontes ◽  
Wael Sakr ◽  
...  


2010 ◽  
Vol 77 (3) ◽  
pp. 784-787 ◽  
Author(s):  
Hendrik Isbarn ◽  
Pierre I. Karakiewicz ◽  
Susanne Vogel ◽  
Claudio Jeldres ◽  
Giovanni Lughezzani ◽  
...  


2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 16047-16047
Author(s):  
R. Valdagni ◽  
N. Nicolai ◽  
T. Rancati ◽  
S. Stagni ◽  
S. Villa ◽  
...  


2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Sangchul Lee ◽  
Jung Keun Lee ◽  
Chang Wook Jeong ◽  
Seong Jin Jeong ◽  
Sung Kyu Hong ◽  
...  


2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Hiten Patel ◽  
Mohit Gupta ◽  
Jeffrey Tosoian ◽  
H. Ballentine Carter ◽  
Alan Partin ◽  
...  


2020 ◽  
Author(s):  
Lei Wu ◽  
Guojun Yue ◽  
Wen Quan ◽  
Qiong Luo ◽  
Dongxu Peng ◽  
...  

Abstract Background: Autophagy is a highly conserved homeostatic process in the human body that is responsible for the elimination of aggregated proteins and damaged organelles. Several autophagy-related genes (ARGs) contribute to the process of tumorigenesis and metastasis of prostate cancer (PCa). Also, miRNAs have been proven to modulate autophagy by targeting some ARGs. However, their potential role in PCa still remains unclear.Methods: An univariate Cox proportional regression model was used to identify 17 ARGs associated with the overall survival (OS) of PCa. Then, a multivariate Cox proportional regression model was used to construct a 6 autophagy-related prognostic genes signature. Patients were divided into low-risk group and high-risk group using the median risk score as a cutoff value. High-risk patients had shorter OS than low-risk patients. Furthermore, the signature was validated by ROC curves. Regarding mRNA and miRNA, 12 differentially expressed miRNAs (DEMs) and 1073 differentially expressed genes (DEGs) were detected via the GEO database. We found that miR-205, one of the DEMs, was negatively regulated the expression of ARG (NKX2-3). Based on STRING analysis results, we found that the NKX2-3 was moderately related to the part of genes among the 6 autophagy-related genes prognostic signature. Further, NKX 2-3 was significantly correlated with OS and some clinical parameters of PCa by cBioProtal. By gene set enrichment analysis (GSEA). Lastly, we demonstrated that the association between NKX2-3 and tumor mutation burden (TMB) and PDCD1 (programmed cell death 1) of PCa.Results: We identified that the six ARGs expression patterns are independent predictors of OS in PCa patients. Furthermore, our results suggest that ARGs and miRNAs are inter-related. MiR-205 was negatively regulated the expression of ARG (NKX2-3). Further analysis demonstrated that NKX2-3 may be a potential biomarker for predicting the efficacy of anti-PD-1 therapy in PCa.Conclusions: The current study may offer a novel autophagy-related prognostic signature and may identify a promising miRNA-ARG pathway for predicting the efficacy of anti-PD-1 therapy in PCa.



Sign in / Sign up

Export Citation Format

Share Document