293 PAIN THRESHOLD AND STRESS-INDUCED ANALGESIA IN ANOREXIA NERVOSA AND HEALTHY WOMEN: THE ROLE OF STEROID HORMONES

ObjectiveAnorexia nervosa display alterations of reward systems and some authors hypothesize the presence of a “starvation addiction”. The aim of the study is to explore the resting-state functional connectivity of dorsal and ventral striatal nuclei.Method51 subjects with lifetime anorexia nervosa (AN) (35 acute and 16 recovered) and 34 healthy controls underwent high resolution and resting-state functional magnetic resonance imaging.ResultsThe AN group showed a reduced functional connectivity of the putamen in comparison to healthy women and this reduction appeared to be stronger in patients with lifetime binge eating or purging. Both acute and recovered AN groups showed larger left accumbens area in comparison to healthy women. Moreover, the functional connectivity of bilateral nucleus accumbens and putamen showed significant negative correlations with the number of obstetric complications in the AN group.Discussionthe present study supports the hypothesis that AN is associated with structural and functional alterations of striatal networks and unveils a possible role of obstetric complications in the pathogenesis of striatal dysfunction.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Shift Toward Randomness in Brain Networks of Patients With Anorexia Nervosa: The Role of Malnutrition

Frontiers in Neuroscience ◽

10.3389/fnins.2021.645139 ◽

2021 ◽

Vol 15 ◽

Author(s):

Enrico Collantoni ◽

Paolo Meneguzzo ◽

Elena Tenconi ◽

Valentina Meregalli ◽

Renzo Manara ◽

...

Keyword(s):

Anorexia Nervosa ◽

Network Architecture ◽

Diffusion Tensor ◽

Three Dimensional ◽

Global Network ◽

Cortical Volume ◽

Healthy Women ◽

Network Properties ◽

Tractography Data

No study to date investigated structural white matter (WM) connectome characteristics in patients with anorexia nervosa (AN). Previous research in AN found evidence of imbalances in global and regional connectomic brain architecture and highlighted a role of malnutrition in determining structural brain changes. The aim of our study was to explore the characteristics of the WM network architecture in a sample of patients with AN. Thirty-six patients with AN and 36 healthy women underwent magnetic resonance imaging to obtain a high-resolution three-dimensional T1-weighted anatomical image and a diffusion tensor imaging scan. Probabilistic tractography data were extracted and analyzed in their network properties through graph theory tools. In comparison to healthy women, patients with AN showed lower global network segregation (normalized clustering: p = 0.029), an imbalance between global network integration and segregation (i.e., lower small-worldness: p = 0.031), and the loss of some of the most integrative and influential hubs. Both clustering and small-worldness correlated with the lowest lifetime body mass index. A significant relationship was found between the average regional loss of cortical volume and changes in network properties of brain nodes: the more the difference in the cortical volume of brain areas, the more the increase in the centrality of corresponding nodes in the whole brain, and the decrease in clustering and efficiency of the nodes of parietal cortex. Our findings showed an unbalanced connectome wiring in AN patients, which seems to be influenced by malnutrition and loss of cortical volume. The role of this rearrangement in the maintenance and prognosis of AN and its reversibility with clinical improvement needs to be established by future studies.

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The role of steroid hormones and chemical carcinogen benzo(a)pyrene in premature rupture of membranes in preterm pregnancy

GYNECOLOGY ◽

10.26442/2079-5696_19.2.55-58 ◽

2017 ◽

Vol 19 (2) ◽

Author(s):

N.V. Artimuk ◽

N.N. Elizarova ◽

E.G. Polenok

Keyword(s):

Steroid Hormones ◽

Chemical Carcinogen ◽

Premature Rupture Of Membranes ◽

Premature Rupture

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How transcutaneous electrical nerve stimulation (TENS) improves fertility in healthy women, the role of estradiol hormone

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2019.11.02.035 ◽

2019 ◽

Vol 11 (2) ◽

Keyword(s):

Nerve Stimulation ◽

Transcutaneous Electrical Nerve Stimulation ◽

Electrical Nerve Stimulation ◽

Healthy Women

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The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women

10.35248/2165-8048.19.9.313 ◽

2019 ◽

Vol 09 (04) ◽

Author(s):

Keren Grinberg ◽

Dyana Meshalhov ◽

Daniel Adadi ◽

Tomer Biton

Keyword(s):

Quality Of Life ◽

Pain Catastrophizing ◽

Healthy Women ◽

Anxiety Levels

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Interpersonal Psychotherapy for the Treatment of Eating Disorders

The Oxford Handbook of Eating Disorders ◽

10.1093/oxfordhb/9780195373622.013.0020 ◽

2010 ◽

pp. 347-372 ◽

Cited By ~ 1

Author(s):

Marian Tanofsky-Kraff ◽

Denise E. Wilfley

Keyword(s):

Anorexia Nervosa ◽

Clinical Care ◽

Interpersonal Psychotherapy ◽

Future Research ◽

Cognitive Behavior ◽

Research Directions ◽

Routine Clinical Care ◽

Interpersonal Factors ◽

Future Research Directions

Interpersonal psychotherapy (IPT) is a focused, time-limited treatment that targets interpersonal problem(s) associated with the onset and/or maintenance of EDs. IPT is supported by substantial empirical evidence documenting the role of interpersonal factors in the onset and maintenance of EDs. IPT is a viable alternative to cognitive behavior therapy for the treatment of bulimia nervosa and binge eating disorder. The effectiveness of IPT for the treatment of anorexia nervosa requires further investigation. The utility of IPT for the prevention of obesity is currently being explored. Future research directions include enhancing the delivery of IPT for EDs, increasing the availability of IPT in routine clinical care settings, exploring IPT adolescent and parent–child adaptations, and developing IPT for the prevention of eating and weight-related problems that may promote full-syndrome EDs or obesity.

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Facilitating Change in Anorexia Nervosa: The Role of Occupational Therapy

British Journal of Occupational Therapy ◽

10.1177/030802269205500903 ◽

1992 ◽

Vol 55 (9) ◽

pp. 334-339 ◽

Cited By ~ 8

Author(s):

Priscilla Harries

Keyword(s):

Anorexia Nervosa ◽

Occupational Therapy ◽

Multidisciplinary Approach ◽

Projective Art

Patients with anorexia nervosa benefit from a multidisciplinary approach. This article gives a brief description of, first, the illness and its treatment and, secondly, the occupational therapy techniques used at the Maudsley Unit. It then demonstrates the progress of patients through examples of projective art.

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