scholarly journals CV10 COST-EFFECTIVENESS OF LOVASTATIN, CHOLESTYRAMINE AND GEMFIBROZIL FOR THE PRIMARY PREVENTION OF CORONARY HEART DISEASE THROUGH CHOLESTEROL REDUCTION IN CATALONIA, SPAIN

2003 ◽  
Vol 6 (6) ◽  
pp. 630
Author(s):  
P Plans-Rubió ◽  
J Rovira
Author(s):  
Oscar H. Franco ◽  
Arno J. der Kinderen ◽  
Chris De Laet ◽  
Anna Peeters ◽  
Luc Bonneux

Objectives: The aim of this study was to evaluate the cost-effectiveness of four risk-lowering interventions (smoking cessation, antihypertensives, aspirin, and statins) in primary prevention of cardiovascular disease.Methods: Using data from the Framingham Heart Study and the Framingham Offspring study, we built life tables to model the benefits of the selected interventions. Participants were classified by age and level of risk of coronary heart disease. The effects of risk reduction are obtained as numbers of death averted and life-years saved within a 10-year period. Estimates of risk reduction by the interventions were obtained from meta-analyses and costs from Dutch sources.Results: The most cost-effective is smoking cessation therapy, representing savings in all situations. Aspirin is the second most cost-effective (€2,263 to €16,949 per year of life saved) followed by antihypertensives. Statins are the least cost-effective (€73,971 to €190,276 per year of life saved).Conclusions: A cost-effective strategy should offer smoking cessation for smokers and aspirin for moderate and high levels of risk among men 45 years of age and older. Statin therapy is the most expensive option in primary prevention at levels of 10-year coronary heart disease risk below 30 percent and should not constitute the first choice of treatment in these populations.


Circulation ◽  
2017 ◽  
Vol 136 (12) ◽  
pp. 1087-1098 ◽  
Author(s):  
David J. Heller ◽  
Pamela G. Coxson ◽  
Joanne Penko ◽  
Mark J. Pletcher ◽  
Lee Goldman ◽  
...  

2000 ◽  
Vol 20 (2) ◽  
pp. 109-121 ◽  
Author(s):  
Patrizia Berto ◽  
Vicky Munro ◽  
Antonio Gaddi ◽  
Cristina Negrini ◽  
John Hutton ◽  
...  

2017 ◽  
Vol 39 (4) ◽  
pp. 804-818.e3 ◽  
Author(s):  
Stephanie R. Earnshaw ◽  
Cheryl L. McDade ◽  
YiFang Chu ◽  
Lisa E. Fleige ◽  
John L. Sievenpiper

2004 ◽  
Vol 18 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Jan Kowalski ◽  
Lucjan Pawlicki ◽  
Joanna Grycewicz ◽  
Jan Blaszczyk ◽  
Robert Irzmanski ◽  
...  

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