Asymmetric organocatalysis – from biomimetic concepts to applications in asymmetric synthesis

2005 ◽  
Vol 2005 (12) ◽  
pp. 8 ◽  
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Organocatalysis

Expanding the toolbox of asymmetric organocatalysis by continuous-flow process

2015 ◽  
Vol 51 (18) ◽  
pp. 3708-3722 ◽  
Author(s):  
Fernanda G. Finelli ◽  
Leandro S. M. Miranda ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Organic Chemistry ◽  
Asymmetric Synthesis ◽  
Continuous Flow ◽  
Flow Process ◽  
Asymmetric Organocatalysis ◽  
Continuous Flow Process

Despite all the organic chemistry reaction methodologies already developed for the continuous-flow process, asymmetric synthesis is one that has gained less attention.

scholarly journals Step economy in the Stereoselective Synthesis of Functionalized Oxindoles via Organocatalytic Domino/One-pot Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Martina Bortolami ◽  
Francesca Leonelli ◽  
Marta Feroci ◽  
Fabrizio Vetica
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Bioactive Compounds ◽  
Stereoselective Synthesis ◽  
Environmentally Friendly ◽  
Important Class ◽  
One Pot ◽  
Asymmetric Organocatalysis ◽  
Toxic Approach

: Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

Asymmetric synthesis of oxazolines bearing α-stereocenters through radical addition–enantioselective protonation enabled by cooperative catalysis

2021 ◽  
Author(s):  
Yunrong Chen ◽  
Xueqian Ye ◽  
Faqian He ◽  
Xiaoyu Yang
Keyword(s):  
Asymmetric Synthesis ◽  
Conjugate Addition ◽  
Radical Addition ◽  
Photoredox Catalysis ◽  
Cooperative Catalysis ◽  
Asymmetric Organocatalysis

An efficient radical conjugate addition/enantioselective protonation process was developed for the asymmetric synthesis of chiral oxazolines bearing an α-stereocenter through cooperative photoredox catalysis and asymmetric organocatalysis.

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