P1.018 Neuroprotective effect of neuroimmunophilins against 3-nitropropionic acid induced Huntington's chorea like symptoms: possible cognitive dysfunction and biochemical and cellular alterations

2009 ◽  
Vol 15 ◽  
pp. S33
Author(s):  
P. Kumar ◽  
A. Kumar
Keyword(s):  
Cognitive Dysfunction ◽  
Neuroprotective Effect ◽  
Huntington's Chorea ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid ◽  
Cellular Alterations

The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats

2014 ◽  
Vol 92 (3) ◽  
pp. 252-258 ◽  
Author(s):  
Heba M. Mahdy ◽  
Mohamed R. Mohamed ◽  
Manal A. Emam ◽  
Amr M. Karim ◽  
Ashraf Abdel-Naim ◽  
...  
Keyword(s):  
Body Mass ◽  
Neuroprotective Effect ◽  
Treated Group ◽  
Activity Level ◽  
Energy Deficit ◽  
Nissl Staining ◽  
Nitropropionic Acid ◽  
Male Wistar Rats ◽  
Anti Inflammatory ◽  
3 Nitropropionic Acid

Puerarin (Pur), an isoflavonoid extracted from the dried roots of Pueraria lobata, has been reported to be useful in the treatment of various diseases. This study was designed to evaluate the anti-apoptotic and anti-inflammatory activities of Pur against 3-nitropropionic acid (3-NP) induced neurotoxicity. For 5 consecutive days, male Wistar rats were given Pur (200 mg/kg body mass) 30 min before treatment with 20 mg/kg body mass of 3-NP. The striata, hippocampi, and cortices of the 3-NP treated group showed apoptotic damage, inflammation, and energy deficit as well as histopathological lesions. The 3-NP-induced alteration in apoptotic biomarkers (caspase-3 activity/level, cytosolic cytochrome c, Bax/Bcl-2 levels) were significantly ameliorated by Pur treatment. Moreover, Pur pretreatment blocked 3-NP-induced inflammatory biomarkers (NF-κB, TNF-α, and iNOS) and prevented the energy deficit (ATP reduction). Nissl staining further confirmed Pur’s neuroprotective effect. These results indicate that Pur may be a useful preventive approach to various neurodegenerative diseases with underlying apoptosis and neuroinflammation.

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