262 POSTER Membrane androgen receptor induced apoptosis in prostate cancer cells is regulated by Rho/ROCK/actin signaling

2008 ◽  
Vol 6 (12) ◽  
pp. 85-86
Author(s):  
C. Stournaras ◽  
N. Papadopoulou ◽  
I. Charalambopoulos ◽  
A. Gravanis ◽  
K. Alevizopoulos
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Membrane Androgen Receptor

Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells

2008 ◽  
Vol 314 (17) ◽  
pp. 3162-3174 ◽  
Author(s):  
N PAPADOPOULOU ◽  
I CHARALAMPOPOULOS ◽  
K ALEVIZOPOULOS ◽  
A GRAVANIS ◽  
C STOURNARAS
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Induced Apoptosis ◽  
Membrane Androgen Receptor

scholarly journals AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells

2021 ◽  
Vol 22 (20) ◽  
pp. 11246
Author(s):  
Kyung-Hwa Jeon ◽  
Seojeong Park ◽  
Hae Jin Jang ◽  
Soo-Yeon Hwang ◽  
Aarajana Shrestha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Topoisomerase Ii ◽  
G1 Arrest ◽  
Castration Resistant Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Catalytic Inhibitor ◽  
Apoptotic Activity ◽  
Induced Apoptosis

Castration-resistant prostate cancer (CRPC) is a clinical challenge in treatment because of its aggressive nature and resistance to androgen deprivation therapy. Topoisomerase II catalytic inhibitors have been suggested as a strategy to overcome these issues. We previously reported AK-I-190 as a novel topoisomerase II inhibitor. In this study, the mechanism of AK-I-190 was clarified using various types of spectroscopic and biological evaluations. AK-I-190 showed potent topoisomerase II inhibitory activity through intercalating into DNA without stabilizing the DNA-enzyme cleavage complex, resulting in significantly less DNA toxicity than etoposide, a clinically used topoisomerase II poison. AK-I-190 induced G1 arrest and effectively inhibited cell proliferation and colony formation in combination with paclitaxel in an androgen receptor–negative CRPC cell line. Our results confirmed that topoisomerase II catalytic inhibition inhibited proliferation and induced apoptosis of AR-independently growing prostate cancer cells. These findings indicate the clinical relevance of topoisomerase II catalytic inhibitors in androgen receptor-negative prostate cancer.

scholarly journals Membrane androgen receptor sensitive Na+/H+exchanger activity in prostate cancer cells

FEBS Letters ◽  
2014 ◽  
Vol 588 (9) ◽  
pp. 1571-1579 ◽  
Author(s):  
Soumya Chatterjee ◽  
Sebastian Schmidt ◽  
Stella Pouli ◽  
Sabina Honisch ◽  
Saad Alkahtani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Membrane Androgen Receptor

609: Effects of Sirna and Phytoestrogen Treatments on the Expression of Genes Regulated through the Androgen Receptor of Lncap Prostate Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 162-162
Author(s):  
Paul Thelen ◽  
Michal Grzmil ◽  
Iris E. Eder ◽  
Barbara Spengler ◽  
Peter Burfeind ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Expression Of Genes
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