213 Duplication of chromosome 17 CEP predicts for anthracycline benefit: evidence from an international meta-analysis of 4 adjuvant breast cancer trials for the HER2/TOP2A meta-analysis study group

2010 ◽  
Vol 8 (3) ◽  
pp. 121 ◽  
Author(s):  
J.M.S. Bartlett ◽  
A. Munro ◽  
F.P. O'Malley ◽  
H. Earl ◽  
C.J. Poole ◽  
...  
1998 ◽  
Vol 78 (5) ◽  
pp. 686-693 ◽  
Author(s):  
J Bernhard ◽  
◽  
C Hürny ◽  
AS Coates ◽  
HF Peterson ◽  
...  

Author(s):  
Kathleen I. Pritchard ◽  
Jonas Bergh ◽  
Harold J. Burstein

Overview: There is great appreciation for the heterogeneity of breast cancers, particularly of hormone-receptor positive breast cancers. A goal of modern oncology managing such heterogeneity is to determine how to individualize therapy based on the specific pathological and biological features of a given tumor. Two distinctive clinical literatures exist to guide treatment of hormone-receptor-positive breast cancer. The Oxford Overview, a seminal meta-analysis effort, has recently been updated, and suggests that nearly all patients with ER-positive tumors benefit from adjuvant endocrine therapy. In addition, the overview finds that nearly all subsets of patients with ER-positive tumors also benefit from modern adjuvant chemotherapy regimens. Meanwhile, retrospective subset analyses of specific trials or populations suggests that the benefits of chemotherapy are not so uniform, and in particular that molecular diagnostics assays can identify patients who do not warrant chemotherapy. This article will highlight recent data and controversies in personalizing adjuvant breast cancer therapy.


Tumor Biology ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 829-839 ◽  
Author(s):  
Zhaolei Cui ◽  
Donghong Lin ◽  
Wenfang Song ◽  
Meihuan Chen ◽  
Dan Li

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Amanda Psyrri ◽  
Konstantine T. Kalogeras ◽  
Ralph M. Wirtz ◽  
George Kouvatseas ◽  
Georgia Karayannopoulou ◽  
...  

2017 ◽  
Vol 24 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Ali Sanjari Moghaddam ◽  
Milad Nazarzadeh ◽  
Zeinab Bidel ◽  
Aliasghar Karamatinia ◽  
Hossein Darvish ◽  
...  

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