Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention

2002 ◽  
Vol 3 (3) ◽  
pp. 166-174 ◽  
Author(s):  
Timothy A Chan
Keyword(s):  
Colon Cancer ◽  
Cancer Chemoprevention ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Clinically Relevant Anti-Inflammatory Agents for Chemoprevention of Colorectal Cancer: New Perspectives

2018 ◽  
Vol 19 (8) ◽  
pp. 2332 ◽  
Author(s):  
Altaf Mohammed ◽  
Nagendra Sastry Yarla ◽  
Venkateshwar Madka ◽  
Chinthalapally V. Rao
Keyword(s):  
Colon Cancer ◽  
Cancer Chemoprevention ◽  
Chemopreventive Agents ◽  
Early Stages ◽  
Drug Classes ◽  
Recent Advancement ◽  
Preclinical Trials ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Further Development

Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin, naproxen, sulindac, celecoxib, and licofelone), statins and other natural agentsboth individually, and in combinations. Most preclinical trials although were efficacious, only few agents entered clinical trials and have been proven to be potential chemopreventive agents for colon cancer. However, there are limitations for these agents that hinder their approval by the food and drug administration for chemoprevention use in high-risk individuals and in patients with early stages of CRC. In this review, we update the recent advancement in pre-clinical and clinical development of selected anti-inflammatory agents (aspirin, naproxen, sulindac, celecoxib, and licofelone) and their combinations for further development as novel colon cancer chemopreventive drugs. We provide further new perspectives from this old research, and insights into precision medicine strategies to overcome unwanted side-effects and overcoming strategies for colon cancer chemoprevention.

scholarly journals Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo

2007 ◽  
Vol 6 (8) ◽  
pp. 2230-2239 ◽  
Author(s):  
Ghenet K. Hagos ◽  
Robert E. Carroll ◽  
Tatiana Kouznetsova ◽  
Qian Li ◽  
Violeta Toader ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antiproliferative Activity ◽  
Cancer Chemoprevention ◽  
Anti Inflammatory

scholarly journals Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs

2015 ◽  
Vol 1 (3) ◽  
pp. 154-160 ◽  
Author(s):  
Ruixia Ma ◽  
Bin Yi ◽  
Gary A. Piazza ◽  
Yaguang Xi
Keyword(s):  
Cancer Chemoprevention ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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