Alcohol consumption and risk of heart failure in the GISSI-PREVENZIONE Study

Background : In case of ischemic hepatic disease, patients with severe heart failure usually remain asymptomatic, while for patients with congestive hepatopathy, signs of right-sided heart failure could mask hepatic injury. However, changes in hepatic function, that are proven by laboratory tests are significant¬ in predicting the survival of patients with severe heart failure. There is possible considerable changes in the involvement of cardiac morbidity among both alcoholics and non alcoholics. This study evaluates the cardiac profile of cirrhotic individuals with respect to their alcohol consumption. Materials and methods : It is a comparative cross sectional study carried out at Medical department of SSIMS and RC, a tertiary medical institute in central part of the Karnataka. Study randomly selected patients with cirrhosis which comprised of 50 alcoholics and 50 non alcoholics. A normal group of 50 individuals without history of alcohol consumption and cirrhosis were selected for secondary comparison. Non Probability Purposive Sampling Technique is used and data was analyzed using latest SPSS for windows. Results : ECHO revealed that all the patients with alcoholic and non alcoholic cirrhosis had abnormal LVIDd (>56mm). LV mass abnormality was found among 76% of patients with non alcoholic cirrhosis compared to 66% of patients with alcoholic cirrhosis. High Ejection fraction abnormality was found among only 4% of patients with non alcoholic cirrhosis. The abnormal E/A ratio was observed among 8% of patients with non alcoholic cirrhosis compared to 4% of alcoholic cirrhosis patients. Conclusion : 2D Echocardiography showed increase in LAD, LVIDd and LV mass among cirrhotic patients thereby suggesting definitive cardiac involvement. The cardiovascular abnormalities did not show much differences between the alcoholic and non alcoholic patients. all cirrhotic patients irrespective of their aetiology has to undergo a cardiovascular evaluation.

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Alcohol Consumption and Risk of Heart Failure: A Meta-Analysis

The Physician and Sportsmedicine ◽

10.3810/psm.2010.10.1812 ◽

2010 ◽

Vol 38 (3) ◽

pp. 84-89 ◽

Cited By ~ 18

Author(s):

Heather Padilla ◽

J. Michael Gaziano ◽

Luc Djoussé

Keyword(s):

Heart Failure ◽

Alcohol Consumption ◽

Meta Analysis

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Moderate alcohol consumption and risk of heart failure among older persons

ACC Current Journal Review ◽

10.1016/s1062-1458(01)00398-1 ◽

2001 ◽

Vol 10 (5) ◽

pp. 54-55

Author(s):

J.L Abramson ◽

S.A Williams ◽

H.M Krumholz ◽

V Vaccarino

Keyword(s):

Heart Failure ◽

Alcohol Consumption ◽

Older Persons ◽

Moderate Alcohol Consumption

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Comparison of Patients Rehospitalized for Heart Failure with Versus Without a History of Habitual Alcohol Consumption

Baylor University Medical Center Proceedings ◽

10.1080/08998280.2014.11929109 ◽

2014 ◽

Vol 27 (3) ◽

pp. 208-209

Author(s):

Ragesh Panikkath ◽

Natalia Suvorava ◽

Neena Ngo ◽

Deepa Panikkath ◽

Sian Yik Lim ◽

...

Keyword(s):

Heart Failure ◽

Alcohol Consumption ◽

History Of

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Association of Alcohol Consumption After Development of Heart Failure With Survival Among Older Adults in the Cardiovascular Health Study

JAMA Network Open ◽

10.1001/jamanetworkopen.2018.6383 ◽

2018 ◽

Vol 1 (8) ◽

pp. e186383 ◽

Cited By ~ 3

Author(s):

Justin S. Sadhu ◽

Eric Novak ◽

Kenneth J. Mukamal ◽

Jorge R. Kizer ◽

Bruce M. Psaty ◽

...

Keyword(s):

Heart Failure ◽

Older Adults ◽

Alcohol Consumption ◽

Cardiovascular Health ◽

Health Study ◽

Cardiovascular Health Study

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Patients with Congestive Heart Failure and Healthy Controls Differ in Vitamin D-Associated Lifestyle Factors

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.77.4.280 ◽

2007 ◽

Vol 77 (4) ◽

pp. 280-288 ◽

Cited By ~ 25

Author(s):

Zittermann ◽

Fischer ◽

Schleithoff ◽

Tenderich ◽

Fuchs ◽

...

Keyword(s):

Heart Failure ◽

Vitamin D ◽

Congestive Heart Failure ◽

Alcohol Consumption ◽

Lifestyle Factors ◽

Ultraviolet B ◽

Controlled Study ◽

Vitamin D Status ◽

Large Cities ◽

Uvb Exposure

We have recently hypothesized that low vitamin D status may contribute to the pathogenesis of congestive heart failure (CHF). This study was aimed at evaluating, in a pilot study, whether CHF patients have indications for a low vitamin D status during earlier periods of their lives. We performed a case-controlled study in 150 CHF patients and 150 controls. Study participants had to answer a questionnaire that included several items concerning vitamin D-associated lifestyle factors during childhood, adolescence, and adulthood. A vitamin D score was constructed. This score takes into consideration that ultraviolet-B (UVB) exposure is the major vitamin D source for humans and that those lifestyle factors, which are associated with regular UVB exposure, can guarantee an adequate vitamin D status at best. The vitamin D score was significantly higher in controls than in patients (p < 0.001). Compared with the controls, more patients lived in large cities (p < 0.001), fewer patients were members of a sport club (p < 0.001), and fewer patients had summer holidays every year (p < 0.01). Patients also reported significantly less alcohol consumption during adulthood than controls (p < 0.001). Our results demonstrate that CHF patients and controls differed in several vitamin D-associated lifestyle factors and in alcohol consumption during earlier periods of their lives.

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