scholarly journals Association of Alcohol Consumption After Development of Heart Failure With Survival Among Older Adults in the Cardiovascular Health Study

2018 ◽  
Vol 1 (8) ◽  
pp. e186383 ◽  
Author(s):  
Justin S. Sadhu ◽  
Eric Novak ◽  
Kenneth J. Mukamal ◽  
Jorge R. Kizer ◽  
Bruce M. Psaty ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Alcohol Consumption ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study

Abstract 04: Incident Heart Failure and Longitudinal Cognitive Trajectories in the Cardiovascular Health Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Christa Schank ◽  
Natalie J Blades ◽  
Sarwat I Chaudhry ◽  
John A Dodson ◽  
W T Longstreth ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Cognitive Decline ◽  
Cardiovascular Health ◽  
Self Report ◽  
Cognitive Test ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Incident Heart Failure ◽  
Rate Of Decline

OBJECTIVE: To determine whether older adults who develop incident heart failure (HF) experience faster cognitive decline than those without HF. METHODS: We analyzed longitudinal cognitive test data from the Cardiovascular Health Study, a community-based study of adults aged 65 years and older. Participants in this analysis did not have HF or history of stroke at baseline and were censored when they experienced incident clinical stroke. Incident HF was identified by self-report of physician-diagnosed HF and confirmed by adjudicated review of inpatient and outpatient medical records and medication use. Outcomes were mean score and rate of decline in mean score on the 100-point Modified Mini-Mental State Examination (3MSE), administered annually up to nine times from 1990 to 1998. A linear mixed effects model was used to model the relationship of cognitive decline with HF and age, adjusted for demographics, health behaviors, and comorbid conditions including hypertension and diabetes. RESULTS: Analyses included 5,211 participants with mean age 74 years at baseline, of whom 545 (10.5%) developed incident HF over a median follow-up of 7.8 years. Mean 3MSE score was lower at the time of HF diagnosis compared with no HF, and declined faster after incident HF compared with no HF. For example, at age 80, covariate-adjusted predicted mean 3MSE score was 88.6 points (95% CI: 88.3, 89.0) in participants without HF, but 87.6 points (95% CI: 87.3, 87.9) in those with newly diagnosed HF. Predicted five-year decline in mean 3MSE score from age 80 to age 85 was 5.9 points (95% CI: 5.7, 6.0) in participants without HF, but 10.0 points (95% CI: 8.6, 11.3) in those diagnosed with incident HF at age 80. Faster decline in 3MSE score after HF diagnosis was seen at all ages studied. The figure shows predicted mean 3MSE score trajectories without HF (solid line) and after HF diagnosed at ages 70, 75, 80, and 85 (dashed lines), with 95% CI shaded. CONCLUSIONS: Older adults diagnosed with incident HF experience faster average cognitive decline than those without HF.

Abstract P370: Healthcare utilization in older adults with chronic heart failure and elevated depressive symptoms: Cardiovascular Health Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Mercedes R Carnethon ◽  
Joseph A Delaney ◽  
Norrina B Allen ◽  
Clyde Yancy ◽  
Calvin Hirsch ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Healthcare Utilization ◽  
Healthcare Costs ◽  
Cardiovascular Health ◽  
Consumer Price Index ◽  
Depression Scale ◽  
Health Study ◽  
Cardiovascular Health Study

Background: Elevated depressive symptoms (EDS) are common in adults with heart failure (HF) and their joint prevalence is associated with worse short- (1 year) and long-term health outcomes. The contribution of EDS to healthcare costs and utilization in a contemporary population of older adults with HF is unknown. Hypothesis: Adults with HF who report EDS will have higher annual healthcare costs and use more resources than their counterparts without EDS. Methods: Participants from the Cardiovascular Health Study who developed HF between baseline and the 11-year follow up and whose data were linked to Medicare Part A and Part B claims were included in the analysis (n=441). HF was adjudicated based on review of medical records and physician questionnaires. EDS was determined if participants scored ≥8 on the abbreviated Centers for Epidemiologic Studies Depression scale. Medicare payments were adjusted using the Medical Consumer Price Index and represented in 2009 dollars. Annual healthcare utilization (i.e., total provider visits, inpatient and outpatient visits) is based on Part B. Linear regression with robust variance estimation was used to determine the relationship of EDS with medical costs or provider counts adjusted for confounders. Results: Participants were 75.9 years old (SD= 5.3), 55% female, 15% black, and 147 (33%) had EDS. Within 2 years, 19% of patients with EDS died vs. 14% in those without EDS. Differences in annual costs between participants with and without EDS were not statistically significant. However, participants with EDS had more provider visits than their counterparts (Table). Conclusion: Despite adults with HF and EDS using more healthcare resources than those without EDS, expenditures did not differ. Higher short-term mortality in adults with EDS could be an explanation.

scholarly journals Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study

2012 ◽  
Vol 96 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Rozenn N Lemaitre ◽  
Colleen Sitlani ◽  
Xiaoling Song ◽  
Irena B King ◽  
Barbara McKnight ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Congestive Heart Failure ◽  
Linolenic Acid ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Transforming growth factor beta-1 and incidence of heart failure in older adults: The Cardiovascular Health Study

Cytokine ◽  
2012 ◽  
Vol 60 (2) ◽  
pp. 341-345 ◽  
Author(s):  
Nicole L. Glazer ◽  
Elizabeth M. Macy ◽  
Thomas Lumley ◽  
Nicholas L. Smith ◽  
Alex P. Reiner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Cardiovascular Health ◽  
Transforming Growth Factor ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Growth Factor Beta

scholarly journals Serum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults

Cardiology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Luc Djousse ◽  
Mary L. Biggs ◽  
Nirupa R. Matthan ◽  
Joachim H. Ix ◽  
Annette L. Fitzpatrick ◽  
...  
Keyword(s):  
Heart Failure ◽  
Older Adults ◽  
Fatty Acids ◽  
Cardiovascular Health ◽  
Cox Regression ◽  
Hormone Replacement ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Nonesterified Fatty Acids

Background: Heart failure (HF) is highly prevalent among older adults and is associated with high costs. Although serum total nonesterified fatty acids (NEFAs) have been positively associated with HF risk, the contribution of each individual NEFA to HF risk has not been examined. Objective: The aim of this study was to examine the association of individual fasting NEFAs with HF risk in older adults. Methods: In this prospective cohort study of older adults, we measured 35 individual NEFAs in 2,140 participants of the Cardiovascular Health Study using gas chromatography. HF was ascertained using review of medical records by an endpoint committee. Results: The mean age was 77.7 ± 4.4 years, and 38.8% were male. During a median follow-up of 9.7 (maximum 19.0) years, 655 new cases of HF occurred. In a multivariable Cox regression model controlling for demographic and anthropometric variables, field center, education, serum albumin, glomerular filtration rate, physical activity, alcohol consumption, smoking, hormone replacement therapy, unintentional weight loss, and all other measured NEFAs, we observed inverse associations (HR [95% CI] per standard deviation) of nonesterified pentadecanoic (15:0) (0.73 [0.57–0.94]), γ-linolenic acid (GLA) (0.87 [0.75–1.00]), and docosahexaenoic acid (DHA) (0.73 [0.61–0.88]) acids with HF, and positive associations of nonesterified stearic (18:0) (1.30 [1.04–1.63]) and nervonic (24:1n-9) (1.17 [1.06–1.29]) acids with HF. Conclusion: Our data are consistent with a higher risk of HF with nonesterified stearic and nervonic acids and a lower risk with nonesterified 15:0, GLA, and DHA in older adults. If confirmed in other studies, specific NEFAs may provide new targets for HF prevention.

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