1P-0177 Inhibitory effect of resveratrol on cyclic strain-induced endothelin-1 gene expression in endothelial cells

2003 ◽  
Vol 4 (2) ◽  
pp. 59
Author(s):  
T.-H. Cheng ◽  
P. Chan ◽  
J.-J. Chen
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Cyclic Strain ◽  
Inhibitory Effect ◽  
Endothelin 1

O6-0317 β-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells

2004 ◽  
Vol 97 ◽  
pp. S32
Author(s):  
Tzu-Hurng Cheng ◽  
Shu-Hui Juan ◽  
Cheng-Hsien Chen ◽  
Paul Chant ◽  
Jin-Jer Cheng
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Cyclic Strain ◽  
Vascular Endothelial ◽  
Endothelin 1

17β-Estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells

2004 ◽  
Vol 287 (3) ◽  
pp. H1254-H1261 ◽  
Author(s):  
Shu-Hui Juan ◽  
Jin-Jer Chen ◽  
Cheng-Hsien Chen ◽  
Heng Lin ◽  
Ching-Feng Cheng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Cyclic Strain ◽  
Inhibitory Effect ◽  
Ros Generation ◽  
Cardiovascular Tissue ◽  
Erk Phosphorylation ◽  
Diphenylene Iodonium ◽  
17Β Estradiol

It has been well documented previously that 17β-estradiol (E2) exerts a protective effect on cardiovascular tissue. The possible role of E2 in the regulation of endothelin (ET)-1 production has been previously reported, although the complex mechanisms by which E2 inhibits ET-1 expression are not completely understood. The aims of this study were to examine whether E2 was able to alter strain-induced ET-1 gene expression and also to identify the putative underlying signaling pathways that exist within endothelial cells. For cultured endothelial cells, E2 (1–100 nM), but not 17α-estradiol, inhibited the level of strain-induced ET-1 gene expression and also peptide secretion. This inhibitory effect elicited by E2 was able to be prevented by the coincubation of endothelial cells with the estrogen receptor antagonist ICI-182,780 (1 μM). E2 also inhibited strain-enhanced NADPH oxidase activity and intracellular reactive oxygen species (ROS) generation as measured by the redox-sensitive fluorescent dye 2′,7′-dichlorofluorescin diacetate and the level of extracellular signal-regulated kinase (ERK) phosphorylation. Furthermore, the presence of E2 and antioxidants such as N-acetylcysteine and diphenylene iodonium were able to elicit a decrease in the level of strain-induced ET-1 secretion, ET-1 promoter activity, ET-1 mRNA, ERK phosphorylation, and activator protein-1 binding activity. In summary, we demonstrated, for the first time, that E2 inhibits strain-induced ET-1 gene expression, partially by interfering with the ERK pathway via the attenuation of strain-induced ROS generation. Thus this study delivers important new insight regarding the molecular pathways that may contribute to the proposed beneficial effects of estrogen on the cardiovascular system.

scholarly journals Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 ◽  
Vol 266 (34) ◽  
pp. 23251-23256
Author(s):  
F.J. Oliver ◽  
G. de la Rubia ◽  
E.P. Feener ◽  
M.E. Lee ◽  
M.R. Loeken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endothelin 1 ◽  
Stimulation Of

scholarly journals Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells

1991 ◽  
Vol 266 (24) ◽  
pp. 16188-16192 ◽  
Author(s):  
M.E. Lee ◽  
D.H. Temizer ◽  
J.A. Clifford ◽  
T. Quertermous
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Binding Protein ◽  
Endothelin 1

Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells

2011 ◽  
Vol 39 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Hong-Jye Hong ◽  
Feng-Lin Hsu ◽  
Shih-Chang Tsai ◽  
Cheng-Hsin Lin ◽  
Ju-Chi Liu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Cyclic Strain ◽  
Tanshinone Iia ◽  
Human Umbilical Vein ◽  
Endothelin 1 ◽  
Umbilical Vein Endothelial Cells
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