DIFFERENT EFFECT OF DIABETES MELLITUS AND OTHER CARDIOVASCULAR RISK FACTORS ON MONOCYTE COUNT IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

2008 ◽  
Vol 9 (1) ◽  
pp. 237
Author(s):  
S.A. Kocaman ◽  
A. Sahinarslan ◽  
T. Timurkaynak
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Stable Coronary Artery Disease ◽  
Monocyte Count ◽  
Artery Disease

scholarly journals Diabetes mellitus and other cardiovascular risk factors in lower-extremity peripheral artery disease versus coronary artery disease: an analysis of 1,121,359 cases from the nationwide databases

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Mitsuyoshi Takahara ◽  
◽  
Osamu Iida ◽  
Shun Kohsaka ◽  
Yoshimitsu Soga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Lower Extremity ◽  
Cardiovascular Risk Factors ◽  
Clinical Profile ◽  
Peripheral Artery ◽  
Artery Disease

Abstract Background Lower-extremity peripheral artery disease (LE-PAD) and coronary artery disease (CAD) are both pathologically rooted in atherosclerosis, and their shared clinical features regarding the exposure to cardiovascular risk factors have been emphasized. However, comparative data of the two cardiovascular diseases (CVDs) were so far lacking. The purpose of this study was to directly compare the clinical profile between cases undergoing endovascular therapy (EVT) for LE-PAD and those undergoing percutaneous coronary intervention (PCI). Methods Data were extracted from the nationwide procedural databases of EVT and PCI in Japan (J-EVT and J-PCI) between 2012 and 2017. A total of 1,121,359 cases (103,887 EVT cases for critical limb ischemia [CLI] or intermittent claudication and 1,017,472 PCI cases for acute coronary syndrome [ACS] or stable angina) were analyzed. Heterogeneity in clinical profile between CVDs was evaluated using the C statistic of the logistic regression model for which dependent variable was one CVD versus another, and explanatory variables were clinical profile. When two CVDs were completely discriminated from each other by the developed model, the C statistic (discrimination ability) of the model would be equal to 1, indicating that the two CVDs were completely different in clinical profile. On the other hand, when two CVDs were identical in clinical profile, the developed model would not discriminate them at all, with the C statistic equal to 0.5. Results Mean age was 73.5 ± 9.3 years in LE-PAD patients versus 70.0 ± 11.2 years in CAD patients (P < 0.001). The prevalence of diabetes mellitus and end-stage renal disease was 1.96- and 6.39-times higher in LE-PAD patients than in CAD patients (both P < 0.001). The higher prevalence was observed irrespective of age group. The exposure to other cardiovascular risk factors and the likelihood of cardiovascular risk clustering also varied between the diseases. The between-disease heterogeneity in patient profile was particularly evident between CLI and ACS, with the C statistic equal to 0.833 (95% CI 0.831–0.836). Conclusions The current study, an analysis based on nationwide procedural databases, confirmed that patient profiles were not identical but rather considerably different between clinically significant LE-PAD and CAD warranting revascularization.

scholarly journals Associations of adipocytokine expression and cardiovascular risk factors in stable coronary artery disease

2021 ◽  
Vol 26 (3) ◽  
pp. 4318
Author(s):  
E. V. Belik ◽  
O. V. Gruzdeva ◽  
Yu. A. Dyleva ◽  
D. A. Borodkina ◽  
M. Yu. Sinitsky ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Stable Coronary Artery Disease ◽  
Perivascular Adipose Tissue ◽  
Fat Depots ◽  
Artery Disease

Aim. To determine the expression of adiponectin, leptin and I interleukin-6 (IL-6) in subcutaneous, epicardial and perivascular adipose tissue, depending on the presence of cardiovascular risk factors.Material and methods. The study included 90 patients with stable coronary artery disease (CAD) who underwent coronary artery bypass grafting. Samples of adipose tissue were obtained during surgery. The levels of matrix ribonucleic acid (mRNA) of the studied adipocytokines were determined in the presence/absence of the main cardiovascular risk factors.Results. Differences in the expression of genes of the studied adipocytokines in different sex and age groups of patients were revealed, depending on the tissue belonging of adipocytes. Expression of adiponectin in the epicardial and perivascular adipose tissue (EАT and PVAT, respectively), as well as of leptin in the PVAT was less pronounced in men. However, the level of IL-6 mRNA in the subcutaneous adipose tissue (SAT) of men was three times higher than in women, and in the PVAT it was lower. The maximum expression of leptin and IL-6 in the EAT and PVAT was found in persons aged 50-59 years. The presence of dyslipidemia is associated with a decrease in the expression of adiponectin in the EAT, PVAT, and IL-6 in the PVAT. In patients with hypertension (HTN), there was a low level of adiponectin mRNA in the EAT against the background of high leptin levels in the EAT and IL-6 in SAT and EAT. In hypertension with a duration of more than 20 years, there was a decrease in adiponectin expression and an increase in leptin in all types of AT. In smokers, an increase in the expression of adiponectin in the SAT, EAT, PVAT and leptin in the SAT, EAT was found.Conclusion. Associations of traditional cardiovascular risk factors with imbalance of adipocytokines of local fat depots in patients with CAD were revealed. The detected imbalance is manifested by a decrease in the expression of cardioprotective adiponectin in the EAT, PVAT, an increase in leptin and IL-6, which is an unfavorable sign. The presence of such risk factors as male sex, age of 50-59 years, dyslipidemia and hypertension in patients can enhance atherogenesis and contribute to the further progression of CAD.

scholarly journals Cardiovascular Risk Factors - Association with Lower Extremity Versus Coronary Artery Disease

2021 ◽  
Vol 26 (1) ◽  
pp. 9-12
Author(s):  
Cornel Ioan Bitea ◽  
Ioan Maniţiu ◽  
Georgiana Bălţat ◽  
Oana Stoia
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Lower Extremity ◽  
Cardiovascular Risk Factors ◽  
Diabetic Patients ◽  
Reactive Protein ◽  
Artery Disease

Abstract Atherosclerosis is the main cause of lower extremity artery disease (LEAD) and coronary artery disease (CAD). These two arterial territories share the major cardiovascular risk factors: smoking, hypertension, dyslipidaemia and diabetes. Current guidelines draw attention to other possible risk factors: homocysteine level, inflammation markers (e.g. high-sensitive C reactive-protein (CRP), interleukin 6) and chronic kidney disease (CKD.) The objective of this study was to evaluate the cardiovascular risk factors strength association with LEAD and CAD on a study population of 203 patients. Our study concluded that smoking seems to be the most powerful risk factor for LEAD, especially for significant lesion in femoral arteries, while diabetes mellitus, hypertension and CKD were significantly associated with CAD. The highest chance of association with multivessel-CAD is for diabetes mellitus compared to hypertension and CKD respectively. Moreover, in diabetic patients the percent of multivessel-CAD was significantly higher than the percent of single-CAD and non-significant CAD.

scholarly journals Association of Cardiovascular Risk Factors and Coronary Artery Lesion Among Coronary Artery Disease Patients

2015 ◽  
Vol 12 (2) ◽  
pp. 137-140 ◽  
Author(s):  
R Koju ◽  
S Humagain ◽  
K Khanal
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Coronary Stenosis ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Artery Disease

Background Coronary artery disease (CAD) is associated with the numbers of risk factors causing coronary atherosclerosis. Coronary artery stenosis is mostly caused by coronary atherosclerosis.Objective This study aims to analyze the association between coronary artery stenosis and cardiovascular risk factors.Methods An observational study was conducted among CAD patients. The diagnostic coronary angiogram was performed from femoral approach using standard catheters and techniques to find out any abnormalities.Result A total 73 patients (44 male and 29 female) with coronary artery disease undergoing diagnostic coronary angiography was included with the documented cardiovascular risk factors. The coronary stenosis was found in 40 patients on the basis of stenosis grading. Among the established cardiovascular risk factors, sex, diabetes mellitus and smokers show are significantly associated with coronary stenosis among CAD patients. The present study shows the significant association of coronary stenosis among male CAD patients (OR 2.47; CI 0.94 – 6.48, p <0.05) and similar association has been observed in diabetes mellitus (OR 3.32; CI 1.12 – 9.84, p <0.05) and smoking (OR 4.10; CI 1.45 – 11.61, p <0.01).Conclusion The prevalence of CAD is increased with numbers of presence of cardiovascular risk factors. Male gender, diabetes mellitus and smoking are significantly associated with coronary stenosis among CAD patients. However, hypertension and dyslipidemia are comparable between coronary stenosis and no significant stenosis group.Kathmandu University Medical Journal Vol.12(2) 2014: 137-140

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