scholarly journals WS16.4 Differences in the ventilatory response to incremental exercise in people with cystic fibrosis according to age and sex

2020 ◽  
Vol 19 ◽  
pp. S27-S28
Author(s):  
C.A. Williams ◽  
O.W. Tomlinson ◽  
N.J. Withers ◽  
PJ. Oades ◽  
A.R. Barker
2000 ◽  
Vol 81 (1-2) ◽  
pp. 100-107 ◽  
Author(s):  
Jacques Prioux ◽  
Michèle Ramonatxo ◽  
Maurice Hayot ◽  
Patrick Mucci ◽  
Christian Préfaut

1991 ◽  
Vol 11 (1) ◽  
pp. 73-82 ◽  
Author(s):  
T. Yoshida ◽  
M. Chida ◽  
M. Ichioka ◽  
K. Makiguchi ◽  
N. Tojo ◽  
...  

CHEST Journal ◽  
2013 ◽  
Vol 144 (4) ◽  
pp. 758A
Author(s):  
Jen Jen Chen ◽  
Shlomit Radom-Aizik ◽  
Szu-Yun Leu ◽  
John Moua ◽  
Inderpal Randhawa ◽  
...  

PEDIATRICS ◽  
1981 ◽  
Vol 68 (2) ◽  
pp. 187-194
Author(s):  
Michel A. Bureau ◽  
Luc Lupien ◽  
Raymond Bégin ◽  
J. Labbé ◽  
N. Gagnon

The drive and performance of breathing during hypercapnia, isocapnic hypoxia, and transient hyperoxia were studied in 20 normal children (mean age 12.3 years), in ten children with asthma, and in ten children with cystic fibrosis (CF) matched by sex and age. These latter two groups of patients had had obstructive respiratory symptoms since infancy and their pulmonary disease was of moderate severity as documented by their pulmonary function studies. During hypercapnia, normal children had a linear increase in minute ventilation (ΔVE), in tidal volume (ΔVT) and in the inspiratory drive (VT/Ti). The drive of breathing was evaluated by the occlusion pressure (P0.1) at functional residual capacity. The P0.1 response to Paco2 was linear. Patients with asthma and CF showed a blunted ventilatory response (ΔVE, ΔVT, VT/Ti) to CO2 but a normal response in P0.1. In normal subjects, the test of isocarbic hypoxia demonstrated an exponential type of increase in ΔVE, ΔVT, and P0.1 as PAo2 decreased from 110 to 40 torr. With severe hypoxia (PAo2 <50 torr), children with CF (but not asthmatic patients) experienced a paradoxical decrease in ΔVE while the drive (P0.1) remained above normal in both groups of patients. Finally, the transient O2 inhalation test caused a decrease in VE of 26%, 21%, and 34%, respectively, in normal subjects, in asthmatic children, and in children with CF. It is concluded that the CO2 and O2 drive of normal children resembles that described for adults and that the CO2 and O2 command of breathing is normal in children with asthma and CF. However, the ventilatory response in children with chronic obstructive pulmonary disease is subnormal probably due to the impairment of the respiratory mechanics. Finally the respiratory depression induced by severe hypoxia in children with CF is unexplained, but it may reflect the high dependency of their respiratory muscle on oxygen supply.


Author(s):  
Juliana Nascimento ◽  
André Albuquerque ◽  
João Salge ◽  
Edilene Moraes ◽  
Mario Terra-Filho

2010 ◽  
Vol 24 (10) ◽  
pp. 2840-2845 ◽  
Author(s):  
Daniel G Carey ◽  
German J Pliego ◽  
John L Rohwer

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