The role of the chemokine receptor CXCR4 and its ligand CXCL12 in prostate cancer

2003 ◽  
Vol 2 (1) ◽  
pp. 163
Author(s):  
M. Arya ◽  
R. Tatoud ◽  
C. Megurk ◽  
E.P.N. O'Donoghue ◽  
H. Klocker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Chemokine Receptor ◽  
Chemokine Receptor Cxcr4

scholarly journals Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

2008 ◽  
Vol 99 (3) ◽  
pp. 539-542 ◽  
Author(s):  
Takuya Akashi ◽  
Keiichi Koizumi ◽  
Koichi Tsuneyama ◽  
Ikuo Saiki ◽  
Yasuo Takano ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Chemokine Receptor ◽  
Metastatic Prostate Cancer ◽  
Cxcr4 Expression ◽  
Chemokine Receptor Cxcr4

Tumor progression in osteosarcoma (OS): Role of the chemokine receptor CXCR4 and of its ligand stromal-cell derived factor 1 (SDF-1)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9021-9021 ◽  
Author(s):  
E. Perissinotto ◽  
V. Fonsato ◽  
G. Cavalloni ◽  
F. Leone ◽  
S. Mitola ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor

scholarly journals Molecular basis of cell migration in the fish lateral line: Role of the chemokine receptor CXCR4 and of its ligand, SDF1

2002 ◽  
Vol 99 (25) ◽  
pp. 16297-16302 ◽  
Author(s):  
N. B. David ◽  
D. Sapede ◽  
L. Saint-Etienne ◽  
C. Thisse ◽  
B. Thisse ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lateral Line ◽  
Chemokine Receptor ◽  
Molecular Basis ◽  
Chemokine Receptor Cxcr4

MP-17.04: Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

Urology ◽  
2007 ◽  
Vol 70 (3) ◽  
pp. 130-131
Author(s):  
T. Akashi ◽  
K. Koizumi ◽  
K. Tsuneyama ◽  
I. Saiki ◽  
Y. Takano ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Chemokine Receptor ◽  
Metastatic Prostate Cancer ◽  
Cxcr4 Expression ◽  
Chemokine Receptor Cxcr4

scholarly journals The Role of Chemokine Receptor CXCR4 in the Biologic Behavior of Human Soft Tissue Sarcoma

Sarcoma ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Roger H. Kim ◽  
Benjamin D. L. Li ◽  
Quyen D. Chu
Keyword(s):  
Soft Tissue ◽  
Chemokine Receptor ◽  
Molecular Basis ◽  
Molecular Pathways ◽  
Poor Clinical Outcome ◽  
Chemokine Receptor Cxcr4 ◽  
Human Soft Tissue ◽  
Pharmacologic Inhibitors ◽  
Sites Of Metastases

The molecular basis of sarcoma remains poorly understood. However, recent studies have begun to uncover some of the molecular pathways involved in sarcomagenesis. The chemokine receptor CXCR4 has been implicated in sarcoma development and has been found to be a prognostic marker for poor clinical outcome. There is growing evidence that overexpression of CXCR4 plays a significant role in development of metastatic disease, especially in directing tumor cells towards the preferential sites of metastases in sarcoma, lung and bone. Although further investigation is necessary to validate these pathways, there is potential for clinical application, particularly in the use of pharmacologic inhibitors of CXCR4 as means of preventing sarcoma metastasis.

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