A hammerhead ribozyme transgene to the human HGF/SF receptor c-Met reduces in vitro invasion and migration in prostate cancer cells

2003 ◽  
Vol 2 (6) ◽  
pp. 54
Author(s):  
Gaynor Davies ◽  
Gareth Watkins ◽  
Wen G Jiang ◽  
Malcolm D Mason
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Hammerhead Ribozyme ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
In Vitro Invasion ◽  
And Migration

scholarly journals Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression

2017 ◽  
Vol 46 (7) ◽  
pp. 1495-1504 ◽  
Author(s):  
Neda Shajari ◽  
Sadaf Davudian ◽  
Tohid Kazemi ◽  
Behzad Mansoori ◽  
Shima Salehi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Related Gene ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

Snail-activated long non-coding RNA PCA3 up-regulates PRKD3 expression by miR-1261 sponging, thereby promotes invasion and migration of prostate cancer cells

Tumor Biology ◽  
2016 ◽  
Vol 37 (12) ◽  
pp. 16163-16176 ◽  
Author(s):  
Jin-Hua He ◽  
Bao-Xia Li ◽  
Ze-Ping Han ◽  
Mao-Xian Zou ◽  
Li Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna

scholarly journals Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
X.M. Tian ◽  
Y.Z. Luo ◽  
P. He ◽  
J. Li ◽  
Z.W. Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals MicroRNA‑155‑5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1

2020 ◽  
Vol 20 (6) ◽  
pp. 1-1
Author(s):  
Lin-Ya Yao ◽  
Jun Ma ◽  
Xue-Ming Zeng ◽  
Jun Ou‑yang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Shuangjian Jiang ◽  
Chengqiang Mo ◽  
Shengjie Guo ◽  
Jintao Zhuang ◽  
Bin Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration

Abstract Background Human bone marrow mesenchymal stem cells (hBMSCs) are implicated in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to investigate the physiological mechanisms by which exosomal miR-205 derived from hBMSCs may modulate the growth of prostate cancer cells. Methods Microarray-based gene expression profiling of prostate cancer was adopted to identify differentially expressed genes and regulatory miRNAs, which identified the candidates RHPN2 and miR-205 as the study focus. Then the binding affinity between miR-205 and RHPN2 was identified using in silico analysis and luciferase activity detection. Prostate cancer cells were co-cultured with exosomes derived from hBMSCs treated with either miR-205 mimic or miR-205 inhibitor. Subsequently, prostate cancer cell proliferation, invasion, migration, and apoptosis were detected in vitro. The effects of hBMSCs-miR-205 on tumor growth were investigated in vivo. Results miR-205 was downregulated, while RHPN2 was upregulated in prostate cancer cells. RHPN2 was a target of miR-205, and upregulated miR-205 inhibited prostate cancer cell proliferation, invasion, and migration and promoted apoptosis by targeting RHPN2. Next, experiments demonstrated that hBMSCs-derived exosomes carrying miR-205 contributed to repressed prostate cancer cell proliferation, invasion, and migration and enhanced apoptosis. Furthermore, in vivo assays confirmed the inhibitory effects of hBMSCs-derived exosomal miR-205 on prostate cancer. Conclusion The hBMSCs-derived exosomal miR-205 retards prostate cancer progression by inhibiting RHPN2, suggesting that miR-205 may present a predictor and potential therapeutic target for prostate cancer.

scholarly journals Estrogen Receptor α Is Crucial in Zearalenone-Induced Invasion and Migration of Prostate Cancer Cells

Toxins ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 98 ◽  
Author(s):  
Karolina Kowalska ◽  
Dominika Habrowska-Górczyńska ◽  
Kinga Urbanek ◽  
Kamila Domińska ◽  
Agnieszka Piastowska-Ciesielska
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Estrogen Receptor Α ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
And Migration
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