513 SACRAL ROOT STIMULATION FOR TREATMENT OF URINARY RETENTION: A NOVEL INTRACANALAR APPROACH USING SELF SIZING NERVE CUFF ELECTRODES. TECHNIQUE DESCRIPTION AND PRELIMINARY RESULTS

2010 ◽  
Vol 9 (2) ◽  
pp. 178
Author(s):  
M.P. Bertapelle ◽  
M. Vottero ◽  
L. Squintone ◽  
R. Carone ◽  
T. Camps ◽  
...  
Keyword(s):  
Urinary Retention ◽  
Preliminary Results ◽  
Nerve Cuff ◽  
Cuff Electrodes ◽  
Nerve Cuff Electrodes ◽  
Root Stimulation

Superficial Peroneal Neuromodulation of Nonobstructive Urinary Retention Induced by Prolonged Pudendal Afferent Activity in Cats

2022 ◽  
Author(s):  
Jialiang Chen ◽  
Yihua Zhong ◽  
Bing Shen ◽  
Jicheng Wang ◽  
Zhijun Shen ◽  
...  
Keyword(s):  
Urinary Retention ◽  
Nerve Stimulation ◽  
Skin Surface ◽  
Thigh Muscle ◽  
Afferent Activity ◽  
Surface Electrodes ◽  
Nerve Cuff ◽  
Cuff Electrodes ◽  
Nerve Cuff Electrodes ◽  
Fowler’S Syndrome

The purpose of this study is to determine if superficial peroneal nerve stimulation (SPNS) can improve nonobstructive urinary retention (NOUR) induced by prolonged pudendal nerve stimulation (PNS). In this exploratory acute study using 8 cats under anesthesia, PNS and SPNS were applied by nerve cuff electrodes. Skin surface electrodes were also used for SPNS. A double lumen catheter was inserted via the bladder dome for bladder infusion and pressure measurement and to allow voiding without a physical urethral outlet obstruction. The voided and postvoid residual (PVR) volumes were also recorded. NOUR induced by repetitive (4-13 times) application of 30-min PNS significantly (p<0.05) reduced voiding efficiency by 49.5±16.8% of control (78.3±7.9%) with a large PVR volume at 208.2±82.6% of control bladder capacity. SPNS (1 Hz, 0.2 ms) at 1.5 to 2 times threshold intensity (T) for inducing posterior thigh muscle contractions was applied either continuously (SPNSc) or intermittently (SPNSi) during cystometrograms to improve the PNS-induced NOUR. SPNSc and SPNSi applied by nerve cuff electrodes significantly (p<0.05) increased voiding efficiency to 74.5±18.9% and 67.0±15.3%, respectively, and reduced PVR volume to 54.5±39.0% and 88.3±56.0%, respectively. SPNSc and SPNSi applied non-invasively by skin surface electrodes also improved NOUR similar to the stimulation applied by a cuff electrode. This study indicates that abnormal pudendal afferent activity could be a pathophysiological cause for the NOUR occurring in Fowler's syndrome and a noninvasive superficial peroneal neuromodulation therapy might be developed to treat NOUR in patients with Fowler's syndrome.

scholarly journals Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jonathan A. Shulgach ◽  
Dylan W. Beam ◽  
Ameya C. Nanivadekar ◽  
Derek M. Miller ◽  
Stephanie Fulton ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Fibers ◽  
The Body ◽  
Evoked Responses ◽  
Gi Tract ◽  
Selective Stimulation ◽  
Nerve Cuff ◽  
Cuff Electrodes ◽  
Nerve Cuff Electrodes ◽  
Stimulation Of

AbstractDysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function and treating disease. However, the vagus nerve also innervates many other organs throughout the body, and off-target effects of VNS could cause major side effects such as changes in blood pressure. In this study, we aimed to achieve selective stimulation of populations of vagal afferents using a multi-contact cuff electrode wrapped around the abdominal trunks of the vagus nerve. Four-contact nerve cuff electrodes were implanted around the dorsal (N = 3) or ventral (N = 3) abdominal vagus nerve in six ferrets, and the response to stimulation was measured via a 32-channel microelectrode array (MEA) inserted into the left or right nodose ganglion. Selectivity was characterized by the ability to evoke responses in MEA channels through one bipolar pair of cuff contacts but not through the other bipolar pair. We demonstrated that it was possible to selectively activate subpopulations of vagal neurons using abdominal VNS. Additionally, we quantified the conduction velocity of evoked responses to determine what types of nerve fibers (i.e., Aδ vs. C) responded to stimulation. We also quantified the spatial organization of evoked responses in the nodose MEA to determine if there is somatotopic organization of the neurons in that ganglion. Finally, we demonstrated in a separate set of three ferrets that stimulation of the abdominal vagus via a four-contact cuff could selectively alter gastric myoelectric activity, suggesting that abdominal VNS can potentially be used to control GI function.

Establishment of an in Vitro Model for Stress Testing of Vagal Nerve Cuff Electrodes

2013 ◽  
Author(s):  
Katja Prystaz ◽  
Christoph Ulmer ◽  
Karin H. Somerlik-Fuchs ◽  
Thilo B. Krueger
Keyword(s):  
Stress Testing ◽  
In Vitro Model ◽  
Vagal Nerve ◽  
Nerve Cuff ◽  
Cuff Electrodes ◽  
Nerve Cuff Electrodes ◽  
Vitro Model

scholarly journals Standing After Spinal Cord Injury With Four-Contact Nerve-Cuff Electrodes for Quadriceps Stimulation

2008 ◽  
Vol 16 (5) ◽  
pp. 473-478 ◽  
Author(s):  
L.E. Fisher ◽  
M.E. Miller ◽  
S.N. Bailey ◽  
J.A. Davis ◽  
J.S. Anderson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Cuff ◽  
Cuff Electrodes ◽  
Cord Injury ◽  
Nerve Cuff Electrodes
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