1034 HIGH PREVALENCE AND INTERACTION OF HYPOGONADISM AND THE METABOLIC SYNDROME IN LONG-TERM SURVIVORS WITH GERM CELL TUMOURS

2011 ◽  
Vol 10 (2) ◽  
pp. 320
Author(s):  
F. Gottardo ◽  
L. Grunwald ◽  
S. Secker ◽  
M. Zitzmann ◽  
G. Gerhard ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Germ Cell ◽  
Germ Cell Tumours ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Long Term Survivors

The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis

2020 ◽  
pp. 48-56
Author(s):  
Vadim Dmitruk ◽  
Svetlana Khardikova ◽  
Marina Gerasimenko ◽  
Inna Evstigneeva ◽  
Tatiana Zaitseva
Keyword(s):  
Metabolic Syndrome ◽  
Psoriasis Vulgaris ◽  
Narrow Band ◽  
The Metabolic Syndrome ◽  
Pathological Conditions ◽  
Tnf Α ◽  
High Prevalence ◽  
Before And After ◽  
Ammatory Cytokine

Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.

scholarly journals Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer

2010 ◽  
Vol 21 (5) ◽  
pp. 1121-1126 ◽  
Author(s):  
M. van Waas ◽  
S.J.C.M.M. Neggers ◽  
R. Pieters ◽  
M.M. van den Heuvel-Eibrink
Keyword(s):  
Metabolic Syndrome ◽  
Childhood Cancer ◽  
The Metabolic Syndrome ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

The Metabolic Syndrome and Disturbances in Hormone Levels in Long-Term Survivors of Disseminated Testicular Cancer

2006 ◽  
Vol 175 (4) ◽  
pp. 1368-1368
Author(s):  
J. Nuver ◽  
A.J. Smit ◽  
B.H. Wolffenbuttel ◽  
W.J. Sluiter ◽  
H.J. Hoekstra ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testicular Cancer ◽  
Hormone Levels ◽  
The Metabolic Syndrome ◽  
Long Term Survivors

scholarly journals Endogenous hypercortisolism in the patient with obesity: the cause or a competing disorder

2016 ◽  
Vol 13 (1) ◽  
pp. 57-61
Author(s):  
Zhanna E. Belaya ◽  
Aleksandr V. Vorontsov ◽  
Aleksandr V. Il'in ◽  
Andrey Y. Grigor'ev ◽  
Lyudmila Y. Rozhinskaya
Keyword(s):  
Metabolic Syndrome ◽  
Weight Gain ◽  
Clinical Manifestations ◽  
Uncontrolled Hypertension ◽  
Adrenal Tumors ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Neurosurgical Treatment

Endogenous hypercortisolism (EH) is a rare endocrine disorder, one of the most frequent manifestations of which is obesity. Due to the high prevalence of the metabolic syndrome and the similarity of the clinical manifestations, EH may remain undiagnosed. However, prompt diagnosis and treatment can effectively promote complete cure of the patient. We describe the clinical case of a patient К., 58 years old, who suffered from morbid obesity, diabetes, uncontrolled hypertension and dyslipidemia. The CT examination revealed bilateral adrenal incidentalomas. The further follow-up let us to establish Cushing's disease. The adrenal tumors in this case may be the results of a long-term stimulation of the adrenal glands by ACTH. There is a possibility that the first manifestation of the disease began at the age of 30 years after the second pregnancy, when she observed weight gain and poorly controlled hypertension. When remission was achieved after neurosurgical treatment, we could observe significant improvements (reduction in body weight of 10 kg, improved glucose levels), but without the full normalization of all complications and symptoms.Conclusion: EH may cause the development of obesity and metabolic syndrome or significantly exacerbate its course. In cases of doubt, weight gain and poorly controlled manifestations of metabolic syndrome screening is justified to exclude EH.

scholarly journals Components of the metabolic syndrome in long-term survivors of testicular cancer

2007 ◽  
Vol 18 (2) ◽  
pp. 241-248 ◽  
Author(s):  
H.S. Haugnes ◽  
N. Aass ◽  
S.D. Fosså ◽  
O. Dahl ◽  
O. Klepp ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testicular Cancer ◽  
The Metabolic Syndrome ◽  
Long Term Survivors
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