The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis

Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.

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1034 HIGH PREVALENCE AND INTERACTION OF HYPOGONADISM AND THE METABOLIC SYNDROME IN LONG-TERM SURVIVORS WITH GERM CELL TUMOURS

European Urology Supplements ◽

10.1016/s1569-9056(11)61015-4 ◽

2011 ◽

Vol 10 (2) ◽

pp. 320

Author(s):

F. Gottardo ◽

L. Grunwald ◽

S. Secker ◽

M. Zitzmann ◽

G. Gerhard ◽

...

Keyword(s):

Metabolic Syndrome ◽

Germ Cell ◽

Germ Cell Tumours ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Long Term Survivors

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The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH

Acta Endocrinologica ◽

10.1530/eje-06-0699 ◽

2007 ◽

Vol 156 (4) ◽

pp. 455-462 ◽

Cited By ~ 50

Author(s):

Agatha A van der Klaauw ◽

Nienke R Biermasz ◽

Edith J M Feskens ◽

Marieke B Bos ◽

Johannes W A Smit ◽

...

Keyword(s):

Metabolic Syndrome ◽

Gh Deficiency ◽

Density Lipoprotein ◽

Population Based ◽

The Metabolic Syndrome ◽

Adult Gh Deficiency ◽

Cardiovascular Morbidity And Mortality ◽

Before And After ◽

Using Data

Objectives: Many reports demonstrate improvements in cardiovascular risk factors during GH replacement (rhGH) in adult GH deficiency (GHD). However, it remains to be determined to what extent these changes translate into a reduction of increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the effects of long-term rhGH replacement on the prevalence of the metabolic syndrome (MS). Design, settings, main outcome measures: The MS was scored by the National Cholesterol Education Program-Adult Treatment Panel III definition in 50 consecutive GHD patients (45 ± 9 years of age), before and after 2 and 5 years of rhGH replacement, and the data of untreated patients were compared with the general population using data from a Dutch population-based study (n = 1062, 44 ± 8 years of age). Results: Hypertriglyceridaemia (46.0 vs 18.5%, P < 0.0001), hypertension (66.0 vs 35.5%, P < 0.0001) and abdominal obesity (38.0 vs 23.4%, P = 0.0178) were more prevalent in untreated patients when compared with controls, resulting in a higher prevalence of the MS in patients (38.0 vs 15.7%, P < 0.0001). During rhGH replacement at a mean dose of 0.5 ± 0.2 mg/day resulting in IGF-I concentrations in the normal age-adjusted reference range, mean high-density lipoprotein cholesterol level increased compared with baseline (P < 0.001). However, the prevalence of (components of) the MS did not change after 2 or 5 years of treatment with rhGH. Conclusion: In this study, the prevalence of the MS in patients with GHD is increased compared with healthy controls, irrespective of rhGH replacement.

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Multiplexed Analysis of Biomarkers Related to Obesity and the Metabolic Syndrome in Human Plasma, Using the Luminex-100 System

Clinical Chemistry ◽

10.1373/clinchem.2004.047084 ◽

2005 ◽

Vol 51 (7) ◽

pp. 1102-1109 ◽

Cited By ~ 131

Author(s):

Mine Y Liu ◽

Antonios M Xydakis ◽

Ron C Hoogeveen ◽

Peter H Jones ◽

E O’Brian Smith ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Plasma Concentrations ◽

Correlation Coefficients ◽

Assay Sensitivity ◽

C Peptide ◽

Monocyte Chemoattractant Protein 1 ◽

The Metabolic Syndrome ◽

Tnf Α ◽

Before And After

Abstract Background: The complex pathology of disease has sparked the development of novel protein expression profiling techniques that require validation in clinical settings. This study focuses on multiplexed analyses of adipocytokines and biomarkers linked to the metabolic syndrome, diabetes, and cardiovascular disease. Methods: Multiplexed immunoassays using fluorescent microspheres and the Luminex-100 system were performed on plasma from 80 obese patients (40 with the metabolic syndrome) before and after 6–8 weeks of diet-induced weight loss. Leptin, insulin, C-peptide, monocyte chemoattractant protein-1 (MCP-1), eotaxin, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and IL-6 concentrations measured with multiplex panels from 3 different manufacturers were compared with results from commercial ELISAs. Detection limits and between- and within-run imprecision were determined for each analyte. Bland–Altman analysis was used to determine agreement between multiplexed immunoassays and ELISAs. Results: Correlation between the Luminex multiplexed assays and ELISAs was good for leptin (Linco), insulin (Linco), MCP-1 (Biosource and Upstate), and eotaxin (Biosource) with correlation coefficients of 0.711–0.895; fair for eotaxin (Upstate) and C-peptide (Linco) with correlation coefficients of 0.496–0.582; and poor for TNF-α, IL-8, and IL-6 (Linco, Biosource, Upstate, and R&D) with correlation coefficients of −0.107 to 0.318. Within- and between-run imprecision values for the multiplex method were generally <15%. Relative changes in plasma leptin and insulin concentrations after diet-induced weight loss were similar whether assessed by multiplex assay or ELISA. Conclusion: Although this technology appears useful in clinical research studies, low assay sensitivity and poor correlations with conventional ELISA methods for some analytes with very low plasma concentrations should be considered when using the Luminex platform in clinical studies.

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Endogenous hypercortisolism in the patient with obesity: the cause or a competing disorder

Obesity and metabolism ◽

10.14341/omet2016157-61 ◽

2016 ◽

Vol 13 (1) ◽

pp. 57-61

Author(s):

Zhanna E. Belaya ◽

Aleksandr V. Vorontsov ◽

Aleksandr V. Il'in ◽

Andrey Y. Grigor'ev ◽

Lyudmila Y. Rozhinskaya

Keyword(s):

Metabolic Syndrome ◽

Weight Gain ◽

Clinical Manifestations ◽

Uncontrolled Hypertension ◽

Adrenal Tumors ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Neurosurgical Treatment

Endogenous hypercortisolism (EH) is a rare endocrine disorder, one of the most frequent manifestations of which is obesity. Due to the high prevalence of the metabolic syndrome and the similarity of the clinical manifestations, EH may remain undiagnosed. However, prompt diagnosis and treatment can effectively promote complete cure of the patient. We describe the clinical case of a patient К., 58 years old, who suffered from morbid obesity, diabetes, uncontrolled hypertension and dyslipidemia. The CT examination revealed bilateral adrenal incidentalomas. The further follow-up let us to establish Cushing's disease. The adrenal tumors in this case may be the results of a long-term stimulation of the adrenal glands by ACTH. There is a possibility that the first manifestation of the disease began at the age of 30 years after the second pregnancy, when she observed weight gain and poorly controlled hypertension. When remission was achieved after neurosurgical treatment, we could observe significant improvements (reduction in body weight of 10 kg, improved glucose levels), but without the full normalization of all complications and symptoms.Conclusion: EH may cause the development of obesity and metabolic syndrome or significantly exacerbate its course. In cases of doubt, weight gain and poorly controlled manifestations of metabolic syndrome screening is justified to exclude EH.

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High prevalence of the metabolic syndrome in hypertensive rural Chinese women

Acta Cardiologica ◽

10.2143/ac.63.5.2033226 ◽

2008 ◽

Vol 63 (5) ◽

pp. 591-598 ◽

Cited By ~ 1

Author(s):

X. Zhang ◽

Z. Sun ◽

D. Zhang ◽

L. Zheng ◽

S. Liu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Chinese Women ◽

The Metabolic Syndrome ◽

High Prevalence

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The Prevalence and Predictors of Hypertension and the Metabolic Syndrome in Police Personnel

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18136728 ◽

2021 ◽

Vol 18 (13) ◽

pp. 6728

Author(s):

James D. Yates ◽

Jeffrey W. F. Aldous ◽

Daniel P. Bailey ◽

Angel M. Chater ◽

Andrew C. S. Mitchell ◽

...

Keyword(s):

Metabolic Syndrome ◽

Density Lipoprotein ◽

Cross Sectional ◽

Job Type ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Police Personnel ◽

Behavioural Factors ◽

Cardiometabolic Risk Markers ◽

Police Forces

Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in ‘operational’ and ‘non-operational’ job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.

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Prevalence of the metabolic syndrome in women with a previous diagnosis of polycystic ovary syndrome: long-term follow-up

Fertility and Sterility ◽

10.1016/j.fertnstert.2011.08.006 ◽

2011 ◽

Vol 96 (5) ◽

pp. 1271-1274 ◽

Cited By ~ 26

Author(s):

Miriam Hudecova ◽

Jan Holte ◽

Matts Olovsson ◽

Anders Larsson ◽

Christian Berne ◽

...

Keyword(s):

Metabolic Syndrome ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

The Metabolic Syndrome ◽

Previous Diagnosis ◽

Long Term Follow Up

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Abstract P033: Relationship Between Adiponectin Level and Metabolic Syndrome after Weight Loss in Patients with Abdominal Obesity

Circulation ◽

10.1161/circ.127.suppl_12.ap033 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Aelita Berezina ◽

Olga Belyaeva ◽

Olga Berkovich ◽

Elena Baranova ◽

Tatyina Karonova

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Abdominal Obesity ◽

Metabolic Disorders ◽

Intervention Program ◽

Adiponectin Level ◽

The Metabolic Syndrome ◽

Outpatient Intervention ◽

Before And After ◽

The Relationship

Objective: to investigate the relationship between adiponectin level and metabolic syndrome (MS) after weight loss in patients with abdominal obesity (AO). Method: A 3-year randomized lifestyle intervention trial performed in 153 patients with AO, age 43,2±0,8 yrs, BMI 32,1±1,9 kg/m 2 . 74 patients keep hypocaloric diet (gr.1), 79 patients keep diet and performed aerobic exercise (gr.2). Adiponectin concentration, body mass (BM), waist circumference (WC), body fat (BF), BMI, the levels of BP, glucose, insulin, HOMA-IR, TC, HDL-C, LDL-C, TG, CRP were measured before and after a 3-years outpatient intervention program. Results. 100% patients with AO had some metabolic disorders and 38% had MS before the treatment. The adiponectin levels and others parameters didn’t differ between the groups before intervention (p>0,05). In 3 years 53 (71,6%) and 58 (73,4%) patients from 1 and 2 groups reduced weight. The rate of improving BM, BMI, BF, WC, HDL-C, TG and insulin was grater in patients gr.2 (p<0,05). The favorable dynamics of MS (MS didn’t appeared at the end of study or didn’t registered in patients who had it before) didn’t differ between the groups 1 and 2 (81,1% and 91,4%, p>0,05). The increasing of adiponectin level occurred more often in patients gr.2, than gr.1 (93,1% and 58,5%, p=0,001, respectively). Adiponectin level increased only in patients gr.2 (18,0±1,1mcg/ml and 23,8±1,3 mcg/ml, p= [[Unable to Display Character: р]]=0,0001), didn’t changed in gr.1 (p>0,05). It was established that in patients with combination of weight loss and increasing of adiponectin level favorable dynamics of MS occurred more often than in patients who lost weight without increasing of adiponectin level (91,7% and 69,2%, p=0,0001). In patients with favorable dynamics of MS increasing of adiponectin level had met more often, than in patients with unfavorable dynamics of MS (MS continued or appeared) (88,6% and 11,4%, p=0,0001). Increasing of adiponectin level associated with positive dynamics of the MS - OR=9,1 (4,0-20,6). Conclusion. Combination of weight loss and increasing of adiponectin level associated with favorable dynamics of the metabolic syndrome.

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