Essential research priorities in renal cancer: A modified Delphi consensus statement

Bronchiectasis is a disease of renewed interest in light of an increase in prevalence and increasing burden on international healthcare systems. There are no licensed therapies, and large gaps in knowledge in terms of epidemiology, pathophysiology and therapy. The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration, funded by ERS to promote high-quality research in bronchiectasis. The objective of this consensus statement was to define research priorities in bronchiectasis. From 2014 to 2015, EMBARC used a modified Delphi process among European bronchiectasis experts to reach a consensus on 55 key research priorities in this field. During the same period, the European Lung Foundation collected 711 questionnaires from adult patients with bronchiectasis and their carers from 22 European countries reporting important research priorities from their perspective. This consensus statement reports recommendations for bronchiectasis research after integrating both physicians and patients priorities, as well as those uniquely identified by the two groups. Priorities identified in this consensus statement provide the clearest possible roadmap towards improving our understanding of the disease and the quality of care for patients with bronchiectasis.

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Study of Optimal Perimetric Testing In Children (OPTIC): developing consensus and setting research priorities for perimetry in the management of children with glaucoma

Eye ◽

10.1038/s41433-021-01584-0 ◽

2021 ◽

Author(s):

Dipesh E. Patel ◽

Phillippa M. Cumberland ◽

Bronwen C. Walters ◽

Joseph Abbott ◽

John Brookes ◽

...

Keyword(s):

Visual Field ◽

Research Priorities ◽

Healthcare Setting ◽

Evidence Based ◽

Limited Evidence ◽

Delphi Consensus ◽

Test Quality ◽

Consensus Process ◽

Reliability Indices ◽

Modified Delphi

Abstract Background Perimetry is important in the management of children with glaucoma, but there is limited evidence-based guidance on its use. We report an expert consensus-based study to update guidance and identify areas requiring further research. Methods Experts were invited to participate in a modified Delphi consensus process. Panel selection was based on clinical experience of managing children with glaucoma and UK-based training to minimise diversity of view due to healthcare setting. Questionnaires were delivered electronically, and analysed to establish ‘agreement’. Divergence of opinions was investigated and resolved where possible through further iterations. Results 7/9 experts invited agreed to participate. Consensus (≥5/7 (71%) in agreement) was achieved for 21/26 (80.8%) items in 2 rounds, generating recommendations to start perimetry from approximately 7 years of age (IQR: 6.75–7.25), and use qualitative methods in conjunction with automated reliability indices to assess test quality. There was a lack of agreement about defining progressive visual field (VF) loss and methods for implementing perimetry longitudinally. Panel members highlighted the importance of informing decisions based upon individual circumstances—from gauging maturity/capability when selecting tests and interpreting outcomes, to accounting for specific clinical features (e.g. poor IOP control and/or suspected progressive VF loss) when making decisions about frequency of testing. Conclusions There is commonality of expert views in relation to implementing perimetry and interpreting test quality in the management of children with glaucoma. However, there remains a lack of agreement about defining progressive VF loss, and utilising perimetry over an individuals’ lifetime, highlighting the need for further research.

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A modified Delphi consensus study to identify UK osteopathic profession research priorities

Manual Therapy ◽

10.1016/j.math.2014.04.013 ◽

2014 ◽

Vol 19 (5) ◽

pp. 445-452 ◽

Cited By ~ 7

Author(s):

A.B. Rushton ◽

C.A. Fawkes ◽

D. Carnes ◽

A.P. Moore

Keyword(s):

Research Priorities ◽

Delphi Consensus ◽

Modified Delphi

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The first modified Delphi consensus statement on sleeve gastrectomy

Surgical Endoscopy ◽

10.1007/s00464-020-08216-w ◽

2021 ◽

Author(s):

Kamal K. Mahawar ◽

Islam Omar ◽

Rishi Singhal ◽

Sandeep Aggarwal ◽

Mustafa Ismail Allouch ◽

...

Keyword(s):

Sleeve Gastrectomy ◽

Consensus Statement ◽

Delphi Consensus ◽

Modified Delphi

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The First Modified Delphi Consensus Statement for Resuming Bariatric and Metabolic Surgery in the COVID-19 Times

Obesity Surgery ◽

10.1007/s11695-020-04883-9 ◽

2020 ◽

Cited By ~ 1

Author(s):

Sjaak Pouwels ◽

Islam Omar ◽

Sandeep Aggarwal ◽

Ali Aminian ◽

Luigi Angrisani ◽

...

Keyword(s):

Metabolic Surgery ◽

Consensus Statement ◽

Delphi Consensus ◽

Modified Delphi

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Priorities for collaborative research using very preterm birth cohorts

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/archdischild-2019-317991 ◽

2020 ◽

Vol 105 (5) ◽

pp. 538-544

Author(s):

Jennifer Zeitlin ◽

Mariane Sentenac ◽

Andrei S Morgan ◽

Pierre Yves Ancel ◽

Henrique Barros ◽

...

Keyword(s):

Parental Stress ◽

Social Inclusion ◽

Research Priorities ◽

Preterm Births ◽

Well Being ◽

Birth Cohorts ◽

Delphi Consensus ◽

Very Preterm ◽

Modified Delphi ◽

Extremely Preterm

ObjectivesTo develop research priorities on the consequences of very preterm (VPT) birth for the RECAP Preterm platform which brings together data from 23 European VPT birth cohorts.Design and settingThis study used a two-round modified Delphi consensus process. Round 1 was based on 28 research themes related to childhood outcomes (<12 years) derived from consultations with cohort researchers. An external panel of multidisciplinary stakeholders then ranked their top 10 themes and provided comments. In round 2, panel members provided feedback on rankings and on new themes suggested in round 1.ResultsOf 71 individuals contacted, 64 (90%) participated as panel members comprising obstetricians, neonatologists, nurses, general and specialist paediatricians, psychologists, physiotherapists, parents, adults born preterm, policy makers and epidemiologists from 17 countries. All 28 initial themes were ranked in the top 10 by at least six panel members. Highest ranking themes were: education (73% of panel members' top 10 choices); care and outcomes of extremely preterm births, including ethical decisions (63%); growth and nutrition (60%); emotional well-being and social inclusion (55%); parental stress (55%) and impact of social circumstances on outcomes (52%). Highest ranking themes were robust across panel members classified by background. 15 new themes had at least 6 top 10 endorsements in round 2.ConclusionsThis study elicited a broad range of research priorities on the consequences of VPT birth, with good consensus on highest ranks between stakeholder groups. Several highly ranked themes focused on the socioemotional needs of children and parents, which have been less studied.

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Applied sport science and medicine of women’s rugby codes: a systematic-scoping review and consensus on future research priorities protocol

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2021-001108 ◽

2021 ◽

Vol 7 (3) ◽

pp. e001108

Author(s):

Omar Heyward ◽

Stacey Emmonds ◽

Gregory Roe ◽

Sean Scantlebury ◽

Keith Stokes ◽

...

Keyword(s):

Scoping Review ◽

Research Priorities ◽

Consensus Method ◽

Future Research ◽

Delphi Consensus ◽

Medicine Research ◽

Sport Science ◽

Priority Areas ◽

Wide Range ◽

Scoping Reviews

Women’s rugby (rugby league, rugby union and rugby sevens) has recently grown in participation and professionalisation. There is under-representation of women-only cohorts within applied sport science and medicine research and within the women’s rugby evidence base. The aims of this article are: Part 1: to undertake a systematic-scoping review of the applied sport science and medicine of women’s rugby, and Part 2: to develop a consensus statement on future research priorities. This article will be designed in two parts: Part 1: a systematic-scoping review, and Part 2: a three-round Delphi consensus method. For Part 1, systematic searches of three electronic databases (PubMed (MEDLINE), Scopus, SPORTDiscus (EBSCOhost)) will be performed from the earliest record. These databases will be searched to identify any sport science and medicine themed studies within women’s rugby. The Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews will be adhered to. Part 2 involves a three-round Delphi consensus method to identify future research priorities. Identified experts in women’s rugby will be provided with overall findings from Part 1 to inform decision-making. Participants will then be asked to provide a list of research priority areas. Over the three rounds, priority areas achieving consensus (≥70% agreement) will be identified. This study has received institutional ethical approval. When complete, the manuscript will be submitted for publication in a peer-reviewed journal. The findings of this article will have relevance for a wide range of stakeholders in women’s rugby, including policymakers and governing bodies.

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Aromatic L-amino Acid Decarboxylase (AADC) deficiency: results from an Italian modified Delphi consensus

Italian Journal of Pediatrics ◽

10.1186/s13052-021-00954-4 ◽

2021 ◽

Vol 47 (1) ◽

Cited By ~ 1

Author(s):

Carlo Fusco ◽

◽

Vincenzo Leuzzi ◽

Pasquale Striano ◽

Roberta Battini ◽

...

Keyword(s):

Amino Acid ◽

Diagnostic Delay ◽

Steering Committee ◽

Outcome Data ◽

Diagnosis And Treatment ◽

Acid Decarboxylase ◽

Delphi Consensus ◽

Amino Acid Decarboxylase ◽

Modified Delphi ◽

Number Of Patients

Abstract Background Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare and underdiagnosed neurometabolic disorder resulting in a complex neurological and non-neurological phenotype, posing diagnostic challenges resulting in diagnostic delay. Due to the low number of patients, gathering high-quality scientific evidence on diagnosis and treatment is difficult. Additionally, based on the estimated prevalence, the number of undiagnosed patients is likely to be high. Methods Italian experts in AADC deficiency formed a steering committee to engage clinicians in a modified Delphi consensus to promote discussion, and support research, dissemination and awareness on this disorder. Five experts in the field elaborated six main topics, each subdivided into 4 statements and invited 13 clinicians to give their anonymous feedback. Results 100% of the statements were answered and a consensus was reached at the first round. This enabled the steering committee to acknowledge high rates of agreement between experts on clinical presentation, phenotypes, diagnostic work-up and treatment strategies. A research gap was identified in the lack of standardized cognitive and motor outcome data. The need for setting up an Italian working group and a patients’ association, together with the dissemination of knowledge inside and outside scientific societies in multiple medical disciplines were recognized as critical lines of intervention. Conclusions The panel expressed consensus with high rates of agreement on a series of statements paving the way to disseminate clear messages concerning disease presentation, diagnosis and treatment and strategic interventions to disseminate knowledge at different levels. Future lines of research were also identified.

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