Background. Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration.Methods. Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae. Visceral fat area (VFA), subcutaneous fat area (SCA), and visceral to subcutaneous fat ratio (VF/SC) were evaluated in CD patients on abdominal CT.Results. Lean mass in CD (n=44, mean age:41.2±15.8years, 73% males) was significantly lower than UC (n=53, mean age:33.2±11.2years, 68% males;44.2±7.8versus48.3±8.4 Kg,p=0.01). In both UC/CD, disease severity was associated with nonsignificant decline in BMI (UC:22.1±4.9versus20.2±3.2versus19.9±3.2 kg/m2,p=0.23; CD:22.1±4.2versus19.9±2.3versus19.7±4.2 kg/m2,p=0.18) and fat mass (UC:10.9±8.9versus8.1±5.9versus5.7±3.6 kg,p=0.14; CD:11.2±7versus7.9±4.4versus7.2±5.9 kg,p=0.16), and disease duration was associated with significant decline in FFMI (p<0.05). In CD, disease severity was associated with nonsignificant decline in SCA and increase in VF/SC.Conclusions. CD patients have lower lean mass than UC. Body fat decreases with increasing disease severity and fat-free mass decreases with increasing disease duration in both UC/CD.
P415 MRI assessment of body composition in paediatric Crohn's disease; intra-abdominal adipose tissue association with disease severity
