scholarly journals Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Dawesh P. Yadav ◽  
Saurabh Kedia ◽  
Kumble Seetharama Madhusudhan ◽  
Sawan Bopanna ◽  
Sandeep Goyal ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Body Composition ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Body Fat ◽  
Lean Mass ◽  
Disease Duration ◽  
Subcutaneous Fat ◽  
Fat Free Mass

Background. Results on body composition in Crohn’s disease (CD) and ulcerative colitis (UC) have been heterogeneous and are lacking from Asia. Present study assessed body composition in CD/UC and correlated it with disease severity/duration.Methods. Patients of CD/UC following between Dec 2014 and Dec 2015 who consented for bioimpedance analysis for body fat measurement were included. Lean mass and fat-free mass index (FFMI) were calculated with standard formulae. Visceral fat area (VFA), subcutaneous fat area (SCA), and visceral to subcutaneous fat ratio (VF/SC) were evaluated in CD patients on abdominal CT.Results. Lean mass in CD (n=44, mean age:41.2±15.8years, 73% males) was significantly lower than UC (n=53, mean age:33.2±11.2years, 68% males;44.2±7.8versus48.3±8.4 Kg,p=0.01). In both UC/CD, disease severity was associated with nonsignificant decline in BMI (UC:22.1±4.9versus20.2±3.2versus19.9±3.2 kg/m2,p=0.23; CD:22.1±4.2versus19.9±2.3versus19.7±4.2 kg/m2,p=0.18) and fat mass (UC:10.9±8.9versus8.1±5.9versus5.7±3.6 kg,p=0.14; CD:11.2±7versus7.9±4.4versus7.2±5.9 kg,p=0.16), and disease duration was associated with significant decline in FFMI (p<0.05). In CD, disease severity was associated with nonsignificant decline in SCA and increase in VF/SC.Conclusions. CD patients have lower lean mass than UC. Body fat decreases with increasing disease severity and fat-free mass decreases with increasing disease duration in both UC/CD.

scholarly journals BODY COMPOSITION IN PATIENTS WITH CROHN’S DISEASE AND ULCERATIVE COLITIS

2017 ◽  
Vol 54 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Ivi Ribeiro BACK ◽  
Sonia Silva MARCON ◽  
Natalia Moreno GAINO ◽  
Daniela Salate Biagioni VULCANO ◽  
Mariana de Souza DORNA ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Body Composition ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Nutritional Status ◽  
Inflammatory Bowel Diseases ◽  
Nutritional Assessment ◽  
Overweight And Obesity ◽  
Bowel Diseases ◽  
Inflammatory Bowel

ABSTRACT BACKGROUND The nutritional status of individuals with inflammatory bowel diseases is directly related to the severity of the disease and is associated with poor prognosis and the deterioration of immune competence. OBJECTIVE To assess the nutritional status and the body composition of outpatients with inflammatory bowel diseases. METHODS A cross-sectional study was conducted with clinical and nutritional assessment of patients with Crohn’s disease and ulcerative colitis. Patients were classified according to the clinical activity through Crohn’s Disease Activity Index and Mayo Score. Nutritional assessment consisted of anthropometric measurements of current weight, height, mid-arm circumference, triceps skinfold thickness and thickness of adductor policis muscle, with subsequent calculation of BMI, arm muscle circumference and the mid-arm muscle area (MAMA). The phase angle (PhA) and lean and fat mass were obtained with the use of electrical bioimpedance. Descriptive statistics, chi-square test or Fisher exact test, ANOVA and t-test. RESULTS We evaluated 141 patients of which 54 (38.29%) had Crohn’s disease and 87 (61.70%) ulcerative colitis. The mean age was 43.98 (±15.68) years in Crohn’s disease and 44.28 (±16.29) years for ulcerative colitis. Most of the patients were in clinical remission of the disease (Crohn’s disease: 88.89%; ulcerative colitis: 87.36%). Regarding the nutritional classification using BMI, it was found that 48.15% of Crohn’s disease patients were eutrophic and 40.74% were overweight or obese; among patients with ulcerative colitis, 52.87% were classified as overweight or obese. When considering the triceps skinfold, it was observed in both groups a high percentage of overweight and obesity (Crohn’s disease: 75.93%; ulcerative colitis: 72.42%). Crohn’s disease patients showed the most affected nutritional status according to the nutritional variables when compared to patients with ulcerative colitis (BMI: 24.88 kg/m² x BMI: 26.56 kg/m², P=0.054; MAMA: 35.11 mm x MAMA: 40.39 mm, P=0.040; PhA: 6.46° x PhA: 6.83°, P=0.006). CONCLUSION Patients with inflammatory bowel diseases have a high prevalence of overweight and obesity. Crohn’s disease patients had more impaired anthropometric and body composition indicators when compared to patients with ulcerative colitis.

Mo1867 - Shorter Disease Duration is Associated with Higher Response Rates to Vedolizumab in Crohn's Disease but not Ulcerative Colitis: A Multi-Center Consortium Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-831-S-832 ◽  
Author(s):  
David Faleck ◽  
Adam Winters ◽  
Shreya Chablaney ◽  
Preeti Shashi ◽  
Joseph Meserve ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Response Rates

Hispanic Ethnicity is Associated With Milder Disease Severity in Crohn’s Disease but not Ulcerative Colitis

2014 ◽  
Vol 109 ◽  
pp. S493
Author(s):  
Christie Choi ◽  
Amit Singal ◽  
Kunjali Padhya ◽  
Avegail Flores ◽  
Prabhakar Swaroop ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Hispanic Ethnicity

S1698 High Sero-Reactivity to Food Antigens Correlates with Disease Severity in Crohn's Disease, But Not in Ulcerative Colitis Patients

2009 ◽  
Vol 136 (5) ◽  
pp. A-252
Author(s):  
Takaaki Kawaguchi ◽  
Keiko Saito ◽  
Yasuyo Suga ◽  
Masaki Hashimoto ◽  
Akira Mitsui ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Food Antigens

Su1838 - The Effects of Disease Severity and Surgical Status on Fertility Rates in Crohn's Disease and Ulcerative Colitis

2018 ◽  
Vol 154 (6) ◽  
pp. S-602
Author(s):  
Laura E. Targownik ◽  
Casandra Dolovich ◽  
Leigh Anne Shafer ◽  
Charles N. Bernstein ◽  
Harminder Singh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Fertility Rates

scholarly journals A225 AGE OF DIAGNOSIS DOES NOT IMPACT LIKELIHOOD OF EXPERIENCING POOR IBD-RELATED OUTCOMES

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 100-101
Author(s):  
Y Piracha ◽  
S Reza ◽  
M Fadida ◽  
R Chattha ◽  
M Moradshahi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Regression Analysis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Duration ◽  
Smoking Status ◽  
Forward Selection ◽  
Disease Outcomes ◽  
Age Of Diagnosis ◽  
Poor Outcomes

Abstract Aims The relationship between the age of diagnosis of inflammatory bowel disease (IBD) and adverse disease outcomes has not been well defined. This study aims to determine whether an early age of diagnosis is associated with worse disease outcomes. Methods This was a retrospective study of IBD patients seen at McMaster University Medical Centre, in Hamilton, ON, Canada from 2012 to 2018. Patients were classified as having poor outcomes if they had any of the following: (1) two or more bowel resections since diagnosis; (2) two or more hospitalizations for disease exacerbation since diagnosis; or (3) more than three months of corticosteroid use within 24 months of diagnosis. Prior knowledge in combination with forward selection was used to develop a multivariate logistic regression model and identify predictors of poor IBD outcomes. The variables used in the forward selection model included age at diagnosis (less than vs. greater than 25), smoking status, sex, disease duration, and type of IBD. Results A total of 617 IBD patients were included in the analysis, of which 356 (57.7%) had Crohn’s disease, 234 (37.9%) had ulcerative colitis, and 27 (4.4%) had IBD-U. The median age at diagnosis was 25 (interquartile range (IQR) 17–37). Median disease duration was 16 years (IQR 11–24). A univariate regression analysis indicated that the odds ratio (OR) of poor outcomes was found to be 0.55 (0.38 - 0.79) for those ≥25 years of age compared to to those &lt;25. In the multivariate regression analysis (Table 1), all of disease duration, smoking status, and IBD type were found to have a significant association with having poor outcomes. Each year of disease duration was associated with an increase in odds of poor outcomes (OR 1.06, 95% CI 1.03–1.09). Active smokers had increased odds of poor outcomes compared to past or never smokers (OR 5.01, 95% CI 1.71–14.68). Patients with ulcerative colitis were less likely to experience poor outcomes compared to Crohn’s disease patients (OR 0.38, 95% CI 0.24–0.57). Age of diagnosis was no longer found to have a significant association with poor outcomes, once adjusted for other co-variates (OR 0.74, 95% CI 0.47–1.15). Conclusions Age of diagnosis was not found to have a relationship with occurrence of poor IBD outcomes, after adjustment for co-variates. However, patients with increased disease duration, active smoking status, and Crohn’s disease (compared to UC) were found to have increased odds of poor IBD-related outcomes. Funding Agencies None

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