scholarly journals Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study

2021 ◽  
Vol 9 (7) ◽  
pp. e999-e1008
Author(s):  
Victor Kande Betu Ku Mesu ◽  
Wilfried Mutombo Kalonji ◽  
Clélia Bardonneau ◽  
Olaf Valverde Mordt ◽  
Digas Ngolo Tete ◽  
...  
Keyword(s):  
Cohort Study ◽  
Trypanosoma Brucei ◽  
Early Stage ◽  
Open Label ◽  
Trypanosoma Brucei Gambiense ◽  
Stage 1

scholarly journals PO 8567 ASSOCIATION OF POLYMORPHISM RS 73885319 OF THE APOL1 GENE AND RESISTANCE/SUSCEPTIBILITY TO TRYPANOSOMA BRUCEI GAMBIENSE

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A54.3-A54
Author(s):  
Mwamba Miaka Erick ◽  
Veerle Lejon ◽  
Hamidou Ilboudou ◽  
Philippe Solano
Keyword(s):  
Trypanosoma Brucei ◽  
Neurological Disorders ◽  
Human African Trypanosomiasis ◽  
Democratic Republic ◽  
Central Africa ◽  
Susceptibility To Infection ◽  
Trypanosoma Brucei Gambiense ◽  
Republic Of The Congo ◽  
Asymptomatic Infections ◽  
Stage 1

BackgroundIn Central Africa, human African trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei gambiense (T.b gambiense). Classically, the disease is characterised by an early haemolymphatic phase (stage 1) followed by a meningo-encephalitic phase (stage 2) leading to neurological disorders and death if left untreated. However, field observations suggest that infection by T.b gambiense may result in a great diversity of clinical outcomes ranging from rapid progressions into stage 2, to asymptomatic infections that can last for years or even spontaneous cure in the absence of treatment.The determinants of this clinical diversity are not known but might have their origin both in the parasite (genetic variability) and in the host (individual susceptibility to disease). This study in the Democratic Republic of the Congo aimed at examining the association between the rs73885319 polymorphism of the APOL1 gene and resistance/susceptibility to T. b gambiense. We genotyped the APOL1 gene polymorphism in a total of 257 people comprised of 90 patients, 119 endemic controls and 48 seropositives. The analysis of the results has not shown any significant differences between HAT patients, controls and seropositives. Our results seem to suggest that the G allele of the rs 73885319 polymorphism of the APOL1 gene is not associated to resistance or susceptibility to infection.

Trypanosoma brucei gambiense infection in vervet monkeys: a potential model for early-stage disease

2014 ◽  
Vol 43 (2) ◽  
pp. 72-77 ◽  
Author(s):  
B.M. Gachie ◽  
J.M. Kagira ◽  
S.M. Karanja ◽  
M.W. Waema ◽  
J.M. Ngotho ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Potential Model ◽  
Early Stage ◽  
Vervet Monkeys ◽  
Early Stage Disease ◽  
Trypanosoma Brucei Gambiense ◽  
Stage Disease

scholarly journals Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

BMJ ◽  
2008 ◽  
Vol 336 (7646) ◽  
pp. 705-708 ◽  
Author(s):  
Gerardo Priotto ◽  
Loretxu Pinoges ◽  
Isaac Badi Fursa ◽  
Barbara Burke ◽  
Nathalie Nicolay ◽  
...  
Keyword(s):  
Cohort Study ◽  
Trypanosoma Brucei ◽  
Sleeping Sickness ◽  
First Line ◽  
Trypanosoma Brucei Gambiense

Alterations in the number of motoneurons containing immunoreactive calcitonin gene-related peptide(CGRP)& choline acetyltransferase(ChAT) in the cervical spinal cord of the wobbler mouse during the development of the motoneuron disease

1995 ◽  
Vol 53 ◽  
pp. 970-971
Author(s):  
L. Vacca-Galloway ◽  
Y.Q. Zhang ◽  
P. Bose ◽  
S.H. Zhang
Keyword(s):  
Spinal Cord ◽  
Early Stage ◽  
Cervical Spinal Cord ◽  
Wild Type Mouse ◽  
Reflex Response ◽  
Mouse Strains ◽  
Behavioral Tests ◽  
Wobbler Mouse ◽  
Stage 4 ◽  
Stage 1

The Wobbler mouse (wr) has been studied as a model for inherited human motoneuron diseases (MNDs). Using behavioral tests for forelimb power, walking, climbing, and the “clasp-like reflex” response, the progress of the MND can be categorized into early (Stage 1, age 21 days) and late (Stage 4, age 3 months) stages. Age-and sex-matched normal phenotype littermates (NFR/wr) were used as controls (Stage 0), as well as mice from two related wild-type mouse strains: NFR/N and a C57BI/6N. Using behavioral tests, we also detected pre-symptomatic Wobblers at postnatal ages 7 and 14 days. The mice were anesthetized and perfusion-fixed for immunocytochemical (ICC) of CGRP and ChAT in the spinal cord (C3 to C5).Using computerized morphomety (Vidas, Zeiss), the numbers of IR-CGRP labelled motoneurons were significantly lower in 14 day old Wobbler specimens compared with the controls (Fig. 1). The same trend was observed at 21 days (Stage 1) and 3 months (Stage 4). The IR-CGRP-containing motoneurons in the Wobbler specimens declined progressively with age.

scholarly journals Temporal changes of quantitative CT findings from 102 patients with COVID-19 in Wuhan, China: A longitudinal study

2021 ◽  
Vol 29 ◽  
pp. 297-309
Author(s):  
Xiaohui Chen ◽  
Wenbo Sun ◽  
Dan Xu ◽  
Jiaojiao Ma ◽  
Feng Xiao ◽  
...  
Keyword(s):  
Lung Diseases ◽  
Early Stage ◽  
Temporal Changes ◽  
Time Interval ◽  
Lesion Area ◽  
Quantitative Ct ◽  
Diagnosis And Prognosis ◽  
Ct Findings ◽  
Stage 4 ◽  
Stage 1

BACKGROUND: Computed tomography (CT) imaging combined with artificial intelligence is important in the diagnosis and prognosis of lung diseases. OBJECTIVE: This study aimed to investigate temporal changes of quantitative CT findings in patients with COVID-19 in three clinic types, including moderate, severe, and non-survivors, and to predict severe cases in the early stage from the results. METHODS: One hundred and two patients with confirmed COVID-19 were included in this study. Based on the time interval between onset of symptoms and the CT scan, four stages were defined in this study: Stage-1 (0 ∼7 days); Stage-2 (8 ∼ 14 days); Stage-3 (15 ∼ 21days); Stage-4 (> 21 days). Eight parameters, the infection volume and percentage of the whole lung in four different Hounsfield (HU) ranges, ((-, -750), [-750, -300), [-300, 50) and [50, +)), were calculated and compared between different groups. RESULTS: The infection volume and percentage of four HU ranges peaked in Stage-2. The highest proportion of HU [-750, 50) was found in the infected regions in non-survivors among three groups. CONCLUSIONS: The findings indicate rapid deterioration in the first week since the onset of symptoms in non-survivors. Higher proportion of HU [-750, 50) in the lesion area might be a potential bio-marker for poor prognosis in patients with COVID-19.

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