Sexual behaviour and incidence of HIV and sexually transmitted infections among men who have sex with men using daily and event-driven pre-exposure prophylaxis in AMPrEP: 2 year results from a demonstration study

2019 ◽  
Vol 6 (7) ◽  
pp. e447-e455 ◽  
Author(s):  
Elske Hoornenborg ◽  
Liza Coyer ◽  
Roel C A Achterbergh ◽  
Amy Matser ◽  
Maarten F Schim van der Loeff ◽  
...  
2019 ◽  
Vol 30 (5) ◽  
pp. 486-495
Author(s):  
Kara K Osbak ◽  
Conor J Meehan ◽  
Sergio G Ribas ◽  
Leo Heyndrickx ◽  
Kevin K Ariën ◽  
...  

In this study, we assessed if the superimposition of incident sexually transmitted infections (STIs) on HIV phylogenetic analyses could reveal possible sexual behaviour misclassifications in our HIV-infected population. HIV-1 sequences collected between 1997 and 2014 from 1169 individuals attending a HIV clinic in Antwerp, Belgium were analysed to infer a partial HIV transmission network. Individual demographic, clinical and laboratory data collected during routine HIV follow-up were used to compare clustered and non-clustered individuals using logistic regression analyses. In total, 438 (37.5%) individuals were identified in 136 clusters, including 76 transmission pairs and 60 clusters consisting of three or more individuals. Individuals in a cluster were more likely to have a history of syphilis, Chlamydia and/or gonorrhoea (P < 0.05); however, when analyses were stratified by HIV transmission risk groups (heterosexual and men who have sex with men [MSM]), this association only remained significant for heterosexuals with syphilis (P = 0.001). Under closer scrutiny, this association was driven by six heterosexual men who were located in six almost exclusively MSM clusters. A parsimonious conclusion is that these six individuals were potentially misclassified as heterosexual. Improving the accuracy of sexual behaviour reporting could improve care.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S669-S669 ◽  
Author(s):  
Lucas La Fata ◽  
Laurent Cotte ◽  
Matthieu Godinot ◽  
Aymeric Pansu ◽  
Carole Groslafeige ◽  
...  

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S672-S672 ◽  
Author(s):  
Ronnie Matthew Gravett ◽  
Kachina Kudroff ◽  
Andrew O Westfall ◽  
Edgar Overton ◽  
Christina Muzny ◽  
...  

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