scholarly journals Economic impact of pulsatile hypothermic perfusion in an expanded criteria donor transplant program. Long-term evaluation

2020 ◽  
Vol 19 ◽  
pp. e1440-e1441
Author(s):  
C. Sanchez Guerrero ◽  
V. Gomez Dos Santos ◽  
M. Ruiz Hernandez ◽  
C. Panadero Taravillo ◽  
J.A. Lopez Plaza ◽  
...  
Keyword(s):  
Economic Impact ◽  
Transplant Program ◽  
Expanded Criteria Donor ◽  
Hypothermic Perfusion ◽  
Term Evaluation ◽  
Expanded Criteria ◽  
Donor Transplant

P1690EXPERIENCE WITH EXPANDED CRITERIA DONORS: 10-YEAR SINGLE CENTER ANALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Karol Graňák ◽  
Vnuäã¡k Matej ◽  
Petra Skálová ◽  
Juraj Miklušica ◽  
Ľudovít Laca ◽  
...  
Keyword(s):  
Graft Survival ◽  
Patient Survival ◽  
Graft Function ◽  
Organ Transplant ◽  
First Year ◽  
Transplant Program ◽  
Basic Parameters ◽  
Expanded Criteria ◽  
Expanded Criteria Donors

Abstract Background and Aims Kidneys from expanded criteria donors with diagnosis of brain death have become a part of the organ transplant program, which have thus increased the number of transplants. Method In this retrospective analysis, we identified the expanded criteria donors in a group of 156 kidney donors at our center. Basic parameters of the donors before kidney recovery were collected. Graft function, graft survival, and patient survival at 1, 3, and 5 years posttransplant were compared in expanded criteria versus standard criteria donors. Results Expanded criteria donors were significantly older than standard criteria donors (P < .001), had higher body mass index (P = .006), and had more frequent arterial hypertension (P < .001) and diabetes mellitus (P = .004) in their histories. When we considered the estimated glomerular filtration rate, graft function in the first 6 months after transplant was significantly worse in kidneys from expanded criteria donors (P = .011). In addition, recipients of grafts from expanded criteria donors had significantly worse survival in the first year posttransplant (P = .023); however, no differences in graft survival were observed. Conclusion From the long-term aspect, graft function and graft and patient survival in cases of kidneys from expanded criteria donors were comparable to results with kidneys from standard criteria donors. Expanded use of organs available for transplant is important due to the constantly increasing demands versus limited offers of organs.

Machine Perfusion: Initial Results in an Expanded Criteria Donor Kidney Transplant Program

2015 ◽  
Vol 47 (1) ◽  
pp. 19-22 ◽  
Author(s):  
F.J. Burgos Revilla ◽  
V. Hevia ◽  
V. Diez ◽  
D. Carracedo ◽  
A. Gomis ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Machine Perfusion ◽  
Donor Kidney ◽  
Transplant Program ◽  
Expanded Criteria Donor ◽  
Expanded Criteria ◽  
Initial Results

scholarly journals PDB41 Long-Term Evaluation of the Economic Impact of Reducing HbA1C by 1% in Type 2 Diabetes Patients in Algeria

2012 ◽  
Vol 15 (7) ◽  
pp. A500-A501
Author(s):  
P. Roca ◽  
L. Lamri ◽  
M. Belhadj ◽  
R.F. Pollock ◽  
W.J. Valentine ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Economic Impact ◽  
Term Evaluation ◽  
Diabetes Patients

scholarly journals Predicting Clinical Outcome in Expanded Criteria Donor Kidney Transplantation: A Retrospective Cohort Study

2020 ◽  
Vol 7 ◽  
pp. 205435812092430
Author(s):  
Paramita Saha-Chaudhuri ◽  
Carly Rabin ◽  
Jean Tchervenkov ◽  
Dana Baran ◽  
Justin Morein ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Graft Loss ◽  
Graft Function ◽  
Single Center ◽  
Post Transplant ◽  
Expanded Criteria Donor ◽  
Expanded Criteria

Background: The gaps in organ supply and demand necessitate the use of expanded criteria donor (ECD) kidneys. Objective: To identify which pre-transplant and post-transplant predictors are most informative regarding short- and long-term ECD transplant outcomes. Design: Retrospective cohort study. Setting: Single center, Quebec, Canada. Patients: The patients were 163 consecutive first-time ECD kidney only transplant recipients who underwent transplantation at McGill University Health Centre (MUHC) between January 1, 2008 and December 31, 2014 and had frozen section wedge procurement biopsies. Measurements: Short-term graft outcomes, including delayed graft function and 1-year estimated glomerular filtration rate (eGFR), as well as long-term outcomes including all-cause graft loss (defined as return to dialysis, retransplantation, and death with function). Methods: Pre-transplant donor, recipient, and transplant characteristics were assessed as predictors of transplant outcomes. The added value of post-transplant predictors, including longitudinal eGFR, was also assessed using time-varying Cox proportional hazards models. Results: In univariate analyses, among the pre-transplant donor characteristics, histopathologic variables did not show evidence of association with delayed graft function, 1-year post-transplant eGFR or all cause graft loss. Recipient age was associated with all-cause graft loss (hazard ratio: 1.038 [95% confidence interval: 1.002-1.075] and the model produced only modest discrimination (C-index: 0.590; standard error [SE]: 0.045). Inclusion of time-dependent post-transplant eGFR improved the model’s prediction accuracy (C-index: 0.711; SE = 0.047). Pre-transplant ECD characteristics were not associated with long-term survival, whereas post-transplant characteristics allowed better model discrimination. Limitations: Single-center study, small sample size, and potential incomplete capture of all covariate data. Conclusions: Incorporation of dynamic prediction models into electronic health records may enable timely mitigation of ECD graft failure risk and/or facilitate planning for renal replacement therapies. Histopathologic findings on preimplantation biopsies have a limited role in predicting long-term ECD outcomes. Trial registration: Not applicable.

Sign in / Sign up

Export Citation Format

Share Document