The article is devoted to the characteristics of trends in the accumulation of human capital in Ukraine over the period of independence. The purpose of the article is to study the key factors that caused the existing trends in the accumulation of human capital during the period of independence of Ukraine. The novelty of the study lies in the application of a systematic approach to establishing the influence of the main factors on the accumulation of human capital in the country over the past twenty years.The expediency of the study of factors that directly affect the course of the processes of accumulating human capital at regional and national levels has been substantiated. The relationship between the quality of life of the population, the socio-economic development of the country and the volume of human capital has been established.The conditions (the number and structure of the current population; the number of live births and deaths per year and per 1000 people of the population; natural population decline, the number of marriages registered per year; total annual fertility rate, average life expectancy at birth), typical for Ukraine at the time of its independence in 1991, in the dynamics of demographic and socio-economic processes in Ukraine during the period of its independence have been analyzed.The tendencies that have been achieved by Ukraine in the nineteen years of independence in the field of socio-economic development, such as: the annual decline in the population and the total fertility rate; an increase in the mortality rate of the population; drop in GDP per capita and human development index are established. The key aspects of stabilizing the situation in the field of human capital accumulation in Ukraine, which should be based on the intensive development of the business environment, improving the quality of education, and comprehensive social protection of the population, have been substantiated.