scholarly journals Transmission of COVID-19 on an Inpatient Hospital Prison Unit

2021 ◽  
Vol 1 (S1) ◽  
pp. s47-s47
Author(s):  
Kelsey Witherspoon ◽  
Manisha Shah ◽  
Justin Smyer ◽  
Nora Colburn ◽  
Christina Liscynesky ◽  
...  
Keyword(s):  
Medical Center ◽  
Retrospective Chart Review ◽  
Patient Characteristics ◽  
Index Patient ◽  
Transmission Dynamics ◽  
State University ◽  
Correction Officers ◽  
The Ohio State University ◽  
Prison Populations ◽  
Hospital Acquired

Background: Prison populations have been disproportionally affected by COVID-19, partly due to challenges related to social distancing. Data on viral transmission dynamics in inpatient prison units remain limited. The Ohio State University Wexner Medical Center (OSUWMC) has a 24-bed inpatient prison unit in collaboration with the Ohio Department of Rehabilitations and Corrections (ODRC). The unit has 5 shared rooms holding 4 patients each and 4 single-patient rooms. Several cases of inpatient transmission of COVID-19 were identified on the inpatient prison unit. Methods: An IRB-approved retrospective chart review was conducted to evaluate inpatient transmission dynamics of hospital-acquired (HCA) COVID-19. All ODRC patients admitted from March 1 to April 24, 2020, were included. Patients assigned to the prison unit during their hospital stay were evaluated for potential HCA COVID-19, defined as a positive SARS-CoV-2 test ≥4 days after admission. Patient characteristics, testing data, symptoms, aerosol-generating procedures (AGPs), and room assignments were reviewed. Healthcare workers (HCWs) and correction officers (COs) working on the unit who tested positive during this period were identified. Results: In total, 142 ODRC patients were admitted during the study period and 89% had a positive SARS-CoV-2 testing prior to or during admission. Also, 61 patients (43%) were assigned to the prison unit. Moreover, 8 patients on the unit met potential HCA COVID-19 definition with 7 linked to 3 distinct clusters. Also, 7 COs had COVID-19 (outside hospital exposure) and 5 HCWs acquired COVID-19 from patient exposure on the unit. In cluster 1, 4 patients admitted to the same room developed HCA COVID-19. A symptomatic index patient not tested on admission given an atypical presentation required CPAP and frequent nebulizer treatments. In cluster 2, 1 patient from cluster 1 was transferred to another room. The new roommate subsequently developed HCA COVID-19. In cluster 3, a symptomatic correctional officer was assigned to 2 patients in a shared room; the patients later developed HCA COVID-19. Conclusions: Three patient clusters of HCA COVID-19 on a prison unit were identified. Aerosol transmission potentially played a role in cluster 1. Inpatient transmission within the unit prompted updated guidance for ODRC admissions, including universal SARS-CoV-2 admission testing, excluding patients requiring AGPs from shared rooms, and preemptive isolation for patients from an ODRC facility experiencing a COVID-19 surge. Universal testing was quickly expanded to all inpatient admissions. HCWs and COs were also linked to inpatient transmission, highlighting the importance of strict infection control practices for patient populations who cannot socially distance.Funding: NoDisclosures: None

Pharmacy Issues: Intravenous Drug Ordering

2001 ◽  
Vol 36 (3) ◽  
pp. 329-332
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
Intravenous Drug ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

Pharmacy Issues: Weight-Based Dosing

2001 ◽  
Vol 36 (7) ◽  
pp. 790-791
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

Prevention of Controlled Substance Diversion - Use of Diversion Detection Software

2007 ◽  
Vol 42 (6) ◽  
pp. 564-572 ◽  
Author(s):  
Brian O'neal ◽  
Jerry Siegel
Keyword(s):  
Software Package ◽  
Medical Center ◽  
State University ◽  
University Of Kansas ◽  
Acute Health Care ◽  
Collective Experience ◽  
Controlled Substance ◽  
The Ohio State University ◽  
The University ◽  
Pharmacy Leaders

This is the fifth of a six-part series on diversion of controlled substances in an acute health care setting. The six articles are meant to accompany the recommendations in the Hospital Pharmacy article “Controlled Substance Diversion Detection: Go the Extra Mile” for a comprehensive analysis of all aspects of controlled substance handling. 1 The series focuses on preventing diversion from automated dispensing cabinets (ADCs), the operating room, and at all handling points within a pharmacy. The objective of the series is to provide practical recommendations to aid pharmacy managers as they seek to prevent or detect diversion. Experience is key to diversion detection; however, a pharmacy should not have to experience its own diversion in order to learn from it. The collective experience of pharmacy leaders at the Ohio State University Medical Center and the University of Kansas Hospital are gathered to assist other pharmacy leaders in the hopes that they do not have to gain this experience firsthand. This article will describe the features of one popular reporting software package along with the experience that the University of Kansas Hospital has had in using this software. This description is an attempt to demonstrate the value of an add-on software package and to encourage its use by more hospital pharmacies.

scholarly journals Using Metabolomics to Classify the Underlying Effects of Multi-Nutrient Supplementation in ADHD Youth

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1351-1351
Author(s):  
Madeline Stern ◽  
Leanna Perez ◽  
Jeanette Johnstone ◽  
Barbara Gracious ◽  
Brenda Leung ◽  
...  
Keyword(s):  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Adhd Symptoms ◽  
Open Label ◽  
Nutrient Supplementation ◽  
Open Label Phase ◽  
The Ohio State University ◽  
Double Blinded

Abstract Objectives Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder commonly diagnosed in childhood. Current pharmaceutical treatment options provide a poor long-term risk: benefit ratio with little knowledge of the long-term effects. A broad-spectrum multi-nutrient formula has shown promise in children, but its effects on nutrient status and the underlying metabolome interactions have not been characterized. Methods Blood samples from medication-free children (n = 74) with ADHD enrolled in a double–blind randomized placebo-controlled multinutrient trial (RCT) were collected at baseline and 8 weeks post-intervention. Following RCT is an 8-week open label phase during which all participants took the active supplement. Symptoms were assessed using the Child and Adolescent Symptom Inventory 5. Double-blinded plasma samples will be analyzed for tyrosine, phenylalanine, tryptophan, magnesium, and zinc. Untargeted LC-MS metabolomics using HILIC chromatography and a high resolution QTof will assess very polar analytes in plasma extracts. Linear modeling will elucidate the influence of treatment, sampling time, and ADHD symptom score on plasma nutrient and plasma metabolite concentration. Results Preliminary findings of the open label phase show a significant improvement in inattention (P = 0.0435), hyperactivity (P = 0.0068), ODD (P = 0.0108) and DMDD (P = 0.0119). We hypothesize that these improvements in ADHD symptoms will be correlated with increased circulating concentrations of tyrosine, phenylalanine, tryptophan, magnesium, zinc, and metabolites involved in neurotransmitter synthesis and/or branched chain amino acid metabolism. Conclusions Preliminary findings indicate improvements of ADHD symptoms of inattention, hyperactivity, ODD and DMDD following 8 weeks of open label multi-nutrient supplementation. Results of the double-blinded phase are expected to mirror those observed in the open label phase, with increases in nutrients in those receiving the multinutrient. Funding Sources The sample analyses were supported by NIH Award Number Grant P30 CA016058, OSU, and OSUCCC. Foundation for the Center of Excellence in Mental Health, Canada; The Ohio State University Department of Human Sciences, College of Education and Human Ecology; The Ohio State University Wexner Medical Center, Clinical Research Center.

The Training Process (Part 1)

2003 ◽  
Vol 38 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
Training Process ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University ◽  
Computerized Prescriber Order Entry

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.

Neonatal Intensive Care Unit Pathway

2003 ◽  
Vol 38 (8) ◽  
pp. 794-797
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care Professionals ◽  
Neonatal Intensive Care ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University ◽  
Computerized Prescriber Order Entry

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “pre-scribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.

scholarly journals A single center retrospective analysis of a protocol for high-dose methotrexate and leucovorin rescue administration

2017 ◽  
Vol 25 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Zak Cerminara ◽  
Alison Duffy ◽  
Jennifer Nishioka ◽  
James Trovato ◽  
Steven Gilmore
Keyword(s):  
Medical Center ◽  
Cost Savings ◽  
Retrospective Chart Review ◽  
Patient Characteristics ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Protocol Implementation ◽  
Dose Methotrexate ◽  
Before And After ◽  
The Cost

Background Methotrexate has a wide dosing range. High-dose methotrexate is a dose of 1000 mg/m2 or greater. In the 1970s, the incidence of mortality associated with High-dose methotrexate ranged from 4.6 to 6%. In 2012, the University of Maryland Medical Center implemented a standardized high-dose methotrexate protocol. The purpose of this study was to evaluate whether the institution followed recommendations based on the Bleyer nomogram for the administration of high-dose methotrexate more closely after the implementation of the protocol. Methods In this retrospective chart review, 37 patients received 119 cycles of high-dose methotrexate before the protocol implementation (1 January 2009 through 31 December 2010) and 45 patients received 106 cycles of high-dose methotrexate after protocol implementation (1 January 2013 through 31 December 2014). Patient characteristics, protocol data, and complications were analyzed. Results Protocol implementation significantly reduced the deviation of methotrexate level timing at 24, 48, and 72 h: median 7.47 vs. 1.46 h, 7.23 vs. 1.35 h, and 7.00 vs. 1.52 h before and after implementation, respectively (p < 0.0001 for each). The protocol significantly reduced deviation of the first dose of leucovorin administration: median 5.2 vs. 0.675 h before and after implementation, respectively (p<0.0001). After protocol implementation, there was an increase in the use of leucovorin prescriptions written appropriately for patients discharged before methotrexate levels reached a value of ≤0.05 µmol/L. Conclusions Implementation of a protocol for the administration of high-dose methotrexate improved the adherence to consensus recommendations. Further analysis is needed to assess clinical pharmacist involvement and the cost savings implications within this protocol.

Urinary Incontinence in Juvenile Female Soft-Coated Wheaten Terriers: Hospital Prevalence and Anatomic Urogenital Anomalies

2016 ◽  
Vol 52 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Jason Callard ◽  
Mary A. McLoughlin ◽  
Julie K. Byron ◽  
Dennis J. Chew
Keyword(s):  
Urinary Incontinence ◽  
Medical Center ◽  
Clinical Signs ◽  
Ohio State University ◽  
State University ◽  
Inclusion Criteria ◽  
Related Disorder ◽  
Juvenile Female ◽  
The Ohio State University ◽  
Ectopic Ureters

Urinary incontinence in juvenile female dogs is often associated with urogenital anatomic anomalies. Study objectives include: (1) determine hospital prevalence of urinary incontinence in juvenile female soft-coated wheaten terriers (SCWTs) compared to other affected dogs; (2) characterize anatomic anomalies affecting urinary incontinent juvenile female SCWTs utilizing uroendoscopy; and (3) compare incidence of ectopic ureters, paramesonephric remnants, and short urethras in juvenile female urinary incontinent SCWTs to other juvenile female dogs with urinary incontinence. We hypothesize juvenile SCWTs have an increased prevalence of urinary incontinence and an increased incidence of ectopic ureters, paramesonephric remnants, and short urethras compared to non-SCWTs with urinary incontinence within our hospital population. Medical records of female dogs 6 mo of age and younger with clinical signs of urinary incontinence and video uroendoscopic evaluation presenting to The Ohio State University Veterinary Medical Center from January 2000 to December 2011 were reviewed. Twelve juvenile SCWTs and 107 juvenile non-SCWTs met the inclusion criteria. Juvenile SCWTs were found to have an increased hospital prevalence of urinary incontinence compared to other affected breeds. Observed anomalies in SCWTs include: ectopic ureters, shortened urethras, paramesonephric remnants, and bifid vaginas. This information will help guide veterinarians in recognizing a breed-related disorder of the lower urogenital tract in SCWTs.

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