The aim of this article is to advance political economy and politics into migration studies by analyzing the role of transnational advocacy networks working on issues of trafficking and labor migration in East and Southeast Asia. Drawing on some empirical research, but mainly offering conceptual ideas, we demonstrate the importance of gender not only in trafficking and labor migration but also in transnational advocacy. First, we contextualize trafficking and labor migration within a gendered international political economy, focusing on existing power relations between genders, between classes and between states. Second, we examine the role of transnational advocacy networks in this context. In particular, we argue that a broader understanding of political opportunities and obstacles is needed. Emphasizing the transnational context and the importance of gender, we outline different types of opportunities and obstacles to advocacy in this particular area.