scholarly journals P.016 Hypertensive disorders in pregnancy are associated with future development of vascular dementia: A systematic review and meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S24-S24
Author(s):  
A Switzer ◽  
EE Smith ◽  
A Ganesh
Keyword(s):  
Vascular Dementia ◽  
Meta Analysis ◽  
Alzheimer Dementia ◽  
Motor Processing ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
History Of ◽  
Visual Motor ◽  
Visual Motor Processing ◽  
In Pregnancy

Background: We aimed to evaluate the association between hypertensive disorders in pregnancy (HDP) and future risk of cognitive impairment and dementia. Methods: Systematic searches were performed in MEDLINE and EMBASE up to April 27th, 2020. Exposure of interest included the different types of HDP. Outcomes of interest included dementia incidence, dementia subtype, and cognitive testing. Results: On qualitative review, 4/9 studies showed impaired memory, visual motor processing speed, executive function, and verbal testing in previously preeclamptic women. 2/4 studies showed impaired visual motor processing and subjective cognitive complaints in previously eclamptic women. Six cohort studies involving >2.6 million women were included in the meta-analysis. Pooled hazard ratios (aHR) with 95% confidence intervals were generally adjusted for age at delivery ethnicity, and vascular risk factors. Women with a history of gestational hypertension were more likely to develop vascular dementia (aHR 2.02 [1.45-2.83],I2:0%), but not Alzheimer disease (1.24 [0.93-1.66],single-study). Women with a history of preeclampsia were also more likely to develop vascular dementia (2.17 [1.20-3.91],I2:61.1%), but not Alzheimer dementia (1.19 [0.83-1.69],I2:69.9%). Conclusions: Whereas studies of neuropsychological testing in previously preeclamptic and eclamptic women have been heterogeneous, a history of HDP is associated with developing vascular dementia in later life.

The correlation between PM2.5 exposure and hypertensive disorders in pregnancy: A Meta-analysis

2020 ◽  
Vol 703 ◽  
pp. 134985 ◽  
Author(s):  
Mengqi Sun ◽  
Wu Yan ◽  
Kacey Fang ◽  
Danrong Chen ◽  
Jiani Liu ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
Pm2.5 Exposure ◽  
In Pregnancy

scholarly journals Nutraceuticals and Hypertensive Disorders in Pregnancy: The Available Clinical Evidence

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 378 ◽  
Author(s):  
Silvia Fogacci ◽  
Federica Fogacci ◽  
Arrigo F.G. Cicero
Keyword(s):  
Blood Pressure ◽  
Dietary Supplements ◽  
Search Strategy ◽  
Clinical Evidence ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Hypertensive Disorders ◽  
Pressure Lowering ◽  
Hypertensive Disorders In Pregnancy ◽  
In Pregnancy

The aim of the present critical review is to summarize the available clinical evidence supporting the use of some dietary supplements that have been shown to lower blood pressure in hypertensive pregnant women. A systematic search strategy was carried out to identify trials in MEDLINE (National Library of Medicine, Bethesda, Maryland, MD, USA; January 1980 to September 2019) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). The terms ‘nutraceuticals’, ‘dietary supplements’, ‘pregnancy’, ‘pre-eclampsia’, ‘clinical trial’, and ‘human’ were incorporated into an electronic search strategy. The references of the identified studies and review articles were reviewed to look for additional studies of interest. We preferably selected papers that reported recent comprehensive reviews or meta-analysis, or original clinical trials of substances with blood pressure-lowering or vascular protective effect in pregnancy. There is a relative body of evidence that supports the use of calcium, vitamin D, folic acid, and resveratrol in preventing the development of hypertensive disorders in pregnancy, and evidence supporting drug treatment too. Further clinical research is advisable to identify the dosage and timing of the supplementation, the group of women that might benefit the most from this approach, and the nutraceuticals with the best cost-effectiveness and risk-benefit ratio for widespread use in clinical practice.

Migraine is a Risk Factor for Hypertensive Disorders in Pregnancy: A Prospective Cohort Study

Cephalalgia ◽  
2009 ◽  
Vol 29 (3) ◽  
pp. 286-292 ◽  
Author(s):  
F Facchinetti ◽  
G Allais ◽  
RE Nappi ◽  
R D'Amico ◽  
L Marozio ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Primary Headaches ◽  
Chronic Hypertension ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Hypertensive Disorders In Pregnancy ◽  
History Of ◽  
In Pregnancy

The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11–16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.

Antihypertensive therapy during pregnancy

1995 ◽  
Vol 7 (2) ◽  
pp. 61-76 ◽  
Author(s):  
Radha S Chari ◽  
Steven A Friedman ◽  
Baha M Sibai
Keyword(s):  
Antihypertensive Therapy ◽  
Multiple Gestation ◽  
Perinatal Morbidity ◽  
Familial History ◽  
Previous Pregnancy ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
History Of ◽  
Hydatidiform Moles ◽  
In Pregnancy

Hypertensive disorders in pregnancy are a leading cause of maternal and perinatal morbidity and mortality. Overall, hypertension complicates approximately 10% of pregnancies. The incidence is higher in patients with predisposing factors including nulliparity, multiple gestation, preexisting hypertension or diabetes, a previous pregnancy complicated by preeclampsia-eclampsia, familial history of preeclampsia, hydrops fetalis and rapidly growing hydatidiform moles.

scholarly journals P.076 Hypertensive disorders in pregnancy are strongly associated with future stroke and hypertension: A systematic review and meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S40-S41
Author(s):  
AR Switzer ◽  
EE Smith ◽  
A Ganesh
Keyword(s):  
Gestational Hypertension ◽  
Meta Analysis ◽  
Stroke Mortality ◽  
Case Control Studies ◽  
Stroke Subtype ◽  
Stroke Incidence ◽  
Hypertensive Disorders ◽  
Hazard Ratios ◽  
Hypertensive Disorders In Pregnancy ◽  
In Pregnancy

Background: We aimed to evaluate the association between hypertensive disorders in pregnancy (HDP) and future risk of stroke, stroke death, and hypertension. Methods: Systematic searches were performed in MEDLINE and EMBASE up to April 27th, 2020. Exposure of interest included the different types of HDP. Outcomes of interest included hypertension incidence, stroke incidence, stroke subtype, and stroke mortality. Results: Eighteen cohort and 1 case-control studies involving >10 million women were included in the meta-analysis. Pooled hazard ratios with 95% confidence interval generally adjusted for age at delivery, ethnicity, and vascular risk factors are listed in table 1. Conclusions: Increasing severities of HDP carry higher hazards of hypertension and stroke years later. HDP, including gestational hypertension alone, are also associated with future stroke mortality.

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