Capillary ionic liquid electrospray: beam compositional analysis by orthogonal time-of-flight mass spectrometry

2021 ◽  
Vol 928 ◽  
Author(s):  
S.W. Miller ◽  
J.R. Ulibarri-Sanchez ◽  
B.D. Prince ◽  
R.J. Bemish
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectra ◽  
Time Of Flight ◽  
Ion Source ◽  
High Mass ◽  
Atomic Mass Unit ◽  
Flow Rates ◽  
Charged Species ◽  
Flight Mass Spectrometry ◽  
Jet Breakup

Orthogonal time-of-flight mass spectrometry has been used to characterize the kinetic energy and charged species distributions from an in vacuo electrospray ion source for four different ionic liquids at volumetric flow rates between 0.3 and 3.3 nanolitres per second. In all cases, the mass spectra revealed charged species consisting of singly charged and multiply charged ions as well as two broad, unresolved droplet distributions occurring in the 104 to 106 atomic mass unit per charge range. The mean jet velocity and mean jet breakup potential were established from analysis of the energy profile of the high mass-to-charge droplets. At the jet breakup point, we find the energy loss and the jet diameter flow rate dependence of the electrospray beam to be similar to that determined by Gamero-Castaño (Phys. Fluids, vol. 20, 2008, 032103; Phys. Rev. Fluids, vol. 8, 2021, 013701) for 1-ethyl-3-methylimidazolium bis(trifluromethylsulfonyl)imide at similar volumetric flow rates. Similar trends are observed for all four liquids over the flow regime. A jet instability analysis revealed that jet electrification and viscous effects drive the jet breakup from the case of an uncharged, inviscid jet; jet breakup occurs at droplet and jet radius ratios that deviate from 1.89. Using the analytically determined ratio and the beam profile, different species are modelled to reconstruct the mass spectra; primary droplets constitute only a fraction of the total species present. The populations of the species are discussed.

Investigation of stability and charge state of Ne and Ar gas field ion source by time-of-flight mass spectrometry

2014 ◽  
Vol 53 (5) ◽  
pp. 058004 ◽  
Author(s):  
Shigekazu Nagai ◽  
Tatsuo Iwata ◽  
Ryuta Okawa ◽  
Kazuo Kajiwara ◽  
Koichi Hata
Keyword(s):  
Mass Spectrometry ◽  
Charge State ◽  
Time Of Flight ◽  
Ion Source ◽  
Gas Field ◽  
Flight Mass Spectrometry ◽  
Ar Gas

Rapid identification of stabilisers in polypropylene using time-of-flight mass spectrometry and DART as ion source

The Analyst ◽  
2010 ◽  
Vol 135 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Manuela Haunschmidt ◽  
Christian W. Klampfl ◽  
Wolfgang Buchberger ◽  
Robert Hertsens
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
Rapid Identification ◽  
Ion Source ◽  
Flight Mass Spectrometry

scholarly journals High mass resolution MALDI-TOF MS for profiling biomolecules in mixtures

2018 ◽  
Author(s):  
Wenfa Ng
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
High Sensitivity ◽  
Mass Resolution ◽  
High Mass ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
High Mass Resolution ◽  
Tof Ms

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules by mass spectrometry without inducing fragmentation. Doing so generates an ensemble of ionized intact biomolecules able to be profiled by high sensitivity time-of-flight detector for accurate determination of each biomolecule mass, and thus, identity. Specifically, in time-of-flight detection, high mass resolution determination would require high sensitivity in detecting small differences in time of arrival of biomolecule ions to the detector. While current time-of-flight mass spectrometry provides high mass resolution, greater mass resolution is needed for discriminating different biomolecules in a mixture, where mass differences between biomolecules could be at the sub-Dalton level. With the ability to reliably detect biomolecules with sub-Dalton mass resolution, mass spectrometry with time-of-flight detector such as matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) could find use in identifying the compendium of biomolecules present in a mixture without tedious and time-consuming separation. The larger question would subsequently be coupling sample preparation needs with the conditions conducive for MALDI-TOF MS analysis. Overall, high mass resolution mass spectrometry techniques for profiling biomolecules would find use as an enabling tool in many areas of analytical science and biological sciences such as proteomics and metabolomics.

scholarly journals Plasma profiling-time of flight mass spectrometry: considerations to exploit its analytical performance for materials characterization

2019 ◽  
Vol 34 (4) ◽  
pp. 702-707
Author(s):  
Rocío Muñiz ◽  
Lara Lobo ◽  
Beatriz Fernández ◽  
Rosario Pereiro
Keyword(s):  
Mass Spectrometry ◽  
Glow Discharge ◽  
Mass Spectra ◽  
Time Of Flight ◽  
Analytical Performance ◽  
Materials Characterization ◽  
Solid Materials ◽  
Transient Signals ◽  
Pulsed Glow Discharge ◽  
Flight Mass Spectrometry

The combination of pulsed glow discharge (PGD) with time-of-flight mass spectrometry (TOFMS) provides quasi-simultaneous mass spectra of fast transient signals directly from solid materials.

scholarly journals Detection of high mass molecular ions by laser desorption time-of-flight mass spectrometry.

1988 ◽  
Vol 36 (2) ◽  
pp. 59-69 ◽  
Author(s):  
Tamio Yoshida ◽  
Koichi Tanaka ◽  
Yutaka Ido ◽  
Satoshi Akita ◽  
Yoshikazu Yoshida
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
Laser Desorption ◽  
Molecular Ions ◽  
High Mass ◽  
Flight Mass Spectrometry ◽  
Desorption Time

scholarly journals Screening of Phosphodiesterase-5 Inhibitors and Their Analogs in Dietary Supplements by Liquid Chromatography–Hybrid Ion Trap–Time of Flight Mass Spectrometry

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2734
Author(s):  
Unyong Kim ◽  
Hyun-Deok Cho ◽  
Myung Hee Kang ◽  
Joon Hyuk Suh ◽  
Han Young Eom ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dietary Supplements ◽  
Ion Trap ◽  
Structural Information ◽  
Screening Method ◽  
Time Of Flight ◽  
Ion Source ◽  
Phosphodiesterase 5 Inhibitors ◽  
Flight Mass Spectrometry ◽  
Phosphodiesterase 5

An accurate and reliable method based on ion trap–time of flight mass spectrometry (IT–TOF MS) was developed for screening phosphodiesterase-5 inhibitors, including sildenafil, vardenafil, and tadalafil, and their analogs in dietary supplements. Various parameters affecting liquid chromatographic separation and IT–TOF detection were investigated, and the optimal conditions were determined. The separation was achieved on a reversed-phase column under gradient elution using acetonitrile and water containing 0.2% acetic acid at a flow rate of 0.2 mL/min. The chromatographic eluents were directly ionized in the IT–TOF system equipped with an electrospray ion source operating in the positive ion mode. The proposed screening method was validated by assessing its linearity, precision, and accuracy. Sequential tandem MS was conducted to obtain structural information of the references, and the fragmentation mechanism of each reference was proposed for providing spectral insight for newly synthesized analogs. Structural information, including accurate masses of both parent and fragment ions, was incorporated into the MSn spectral library. The developed method was successfully applied for screening adulterated dietary supplement samples.

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