Rapid identification of stabilisers in polypropylene using time-of-flight mass spectrometry and DART as ion source

The Analyst ◽  
2010 ◽  
Vol 135 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Manuela Haunschmidt ◽  
Christian W. Klampfl ◽  
Wolfgang Buchberger ◽  
Robert Hertsens
Keyword(s):  
Mass Spectrometry ◽  
Time Of Flight ◽  
Rapid Identification ◽  
Ion Source ◽  
Flight Mass Spectrometry

Capillary ionic liquid electrospray: beam compositional analysis by orthogonal time-of-flight mass spectrometry

2021 ◽  
Vol 928 ◽  
Author(s):  
S.W. Miller ◽  
J.R. Ulibarri-Sanchez ◽  
B.D. Prince ◽  
R.J. Bemish
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectra ◽  
Time Of Flight ◽  
Ion Source ◽  
High Mass ◽  
Atomic Mass Unit ◽  
Flow Rates ◽  
Charged Species ◽  
Flight Mass Spectrometry ◽  
Jet Breakup

Orthogonal time-of-flight mass spectrometry has been used to characterize the kinetic energy and charged species distributions from an in vacuo electrospray ion source for four different ionic liquids at volumetric flow rates between 0.3 and 3.3 nanolitres per second. In all cases, the mass spectra revealed charged species consisting of singly charged and multiply charged ions as well as two broad, unresolved droplet distributions occurring in the 104 to 106 atomic mass unit per charge range. The mean jet velocity and mean jet breakup potential were established from analysis of the energy profile of the high mass-to-charge droplets. At the jet breakup point, we find the energy loss and the jet diameter flow rate dependence of the electrospray beam to be similar to that determined by Gamero-Castaño (Phys. Fluids, vol. 20, 2008, 032103; Phys. Rev. Fluids, vol. 8, 2021, 013701) for 1-ethyl-3-methylimidazolium bis(trifluromethylsulfonyl)imide at similar volumetric flow rates. Similar trends are observed for all four liquids over the flow regime. A jet instability analysis revealed that jet electrification and viscous effects drive the jet breakup from the case of an uncharged, inviscid jet; jet breakup occurs at droplet and jet radius ratios that deviate from 1.89. Using the analytically determined ratio and the beam profile, different species are modelled to reconstruct the mass spectra; primary droplets constitute only a fraction of the total species present. The populations of the species are discussed.

Investigation of stability and charge state of Ne and Ar gas field ion source by time-of-flight mass spectrometry

2014 ◽  
Vol 53 (5) ◽  
pp. 058004 ◽  
Author(s):  
Shigekazu Nagai ◽  
Tatsuo Iwata ◽  
Ryuta Okawa ◽  
Kazuo Kajiwara ◽  
Koichi Hata
Keyword(s):  
Mass Spectrometry ◽  
Charge State ◽  
Time Of Flight ◽  
Ion Source ◽  
Gas Field ◽  
Flight Mass Spectrometry ◽  
Ar Gas

scholarly journals Screening of Phosphodiesterase-5 Inhibitors and Their Analogs in Dietary Supplements by Liquid Chromatography–Hybrid Ion Trap–Time of Flight Mass Spectrometry

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2734
Author(s):  
Unyong Kim ◽  
Hyun-Deok Cho ◽  
Myung Hee Kang ◽  
Joon Hyuk Suh ◽  
Han Young Eom ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dietary Supplements ◽  
Ion Trap ◽  
Structural Information ◽  
Screening Method ◽  
Time Of Flight ◽  
Ion Source ◽  
Phosphodiesterase 5 Inhibitors ◽  
Flight Mass Spectrometry ◽  
Phosphodiesterase 5

An accurate and reliable method based on ion trap–time of flight mass spectrometry (IT–TOF MS) was developed for screening phosphodiesterase-5 inhibitors, including sildenafil, vardenafil, and tadalafil, and their analogs in dietary supplements. Various parameters affecting liquid chromatographic separation and IT–TOF detection were investigated, and the optimal conditions were determined. The separation was achieved on a reversed-phase column under gradient elution using acetonitrile and water containing 0.2% acetic acid at a flow rate of 0.2 mL/min. The chromatographic eluents were directly ionized in the IT–TOF system equipped with an electrospray ion source operating in the positive ion mode. The proposed screening method was validated by assessing its linearity, precision, and accuracy. Sequential tandem MS was conducted to obtain structural information of the references, and the fragmentation mechanism of each reference was proposed for providing spectral insight for newly synthesized analogs. Structural information, including accurate masses of both parent and fragment ions, was incorporated into the MSn spectral library. The developed method was successfully applied for screening adulterated dietary supplement samples.

Sign in / Sign up

Export Citation Format

Share Document