scholarly journals Does behavioural inhibition system dysfunction contribute to Attention Deficit Hyperactivity Disorder?

2019 ◽  
Vol 2 ◽  
Author(s):  
S. Sadeghi ◽  
J. McIntosh ◽  
S. M. Shadli ◽  
D. Healey ◽  
R. Rostami ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Stop Signal Task ◽  
Reinforcement Sensitivity Theory ◽  
Behavioural Inhibition ◽  
Hyperactivity Disorder ◽  
Reinforcement Sensitivity ◽  
Externalising Disorders ◽  
Anxiolytic Drugs ◽  
Behavioural Inhibition System

Abstract The Reinforcement Sensitivity Theory of Personality has as its main foundation a Behavioural Inhibition System (BIS), defined by anxiolytic drugs, in which high trait sensitivity should lead to internalising, anxiety, disorders. Conversely, it has been suggested that low BIS sensitivity would be a characteristic of externalising disorders. BIS output should lead to increased arousal and attention as well as behavioural inhibition. Here, therefore, we tested whether an externalising disorder, Attention Deficit Hyperactivity Disorder (ADHD), involves low BIS sensitivity. Goal-Conflict-Specific Rhythmicity (GCSR) in an auditory Stop Signal Task is a right frontal EEG biomarker of BIS function. We assessed children diagnosed with ADHD-I (inattentive) or ADHD-C (combined) and healthy control groups for GCSR in: a) an initial smaller study in Dunedin, New Zealand (population ~120,000: 15 control, 10 ADHD-I, 10 ADHD-C); and b) a main larger one in Tehran, Iran (population ~9 [city]-16 [metropolis] million: 27 control, 18 ADHD-I, 21 ADHD-C). GCSR was clear in controls (particularly at 6–7 Hz) and in ADHD-C (particularly at 8–9 Hz) but was reduced in ADHD-I. Reduced attention and arousal in ADHD-I could be due, in part, to BIS dysfunction. However, hyperactivity and impulsivity in ADHD-C are unlikely to reflect reduced BIS activity. Increased GCSR frequency in ADHD-C may be due to increased input to the BIS. BIS dysfunction may contribute to some aspects of ADHD (and potentially other externalising disorders) and to some differences between the ADHD subtypes but other prefrontal systems (and, e.g. dopamine) are also important.

Dimensions of Impulsivity in Healthy People, Patients with Borderline Personality Disorder, and Patients with Attention-Deficit/Hyperactivity Disorder

2019 ◽  
Vol 25 (4) ◽  
pp. 584-595 ◽  
Author(s):  
Pavla Linhartová ◽  
Jan Širůček ◽  
Anastasia Ejova ◽  
Richard Barteček ◽  
Pavel Theiner ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Attention Deficit ◽  
Latent Variables ◽  
Borderline Personality ◽  
Healthy People ◽  
Stop Signal Task ◽  
Impulsive Behavior ◽  
Hyperactivity Disorder

Objective: Impulsivity, observed in patients with various psychiatric disorders, is a heterogeneous construct with different behavioral manifestations. Through confirmatory factor analysis (CFA), this study tests hypotheses about relationships between dimensions of impulsivity measured using personality questionnaires and behavioral tests. Method: The study included 200 healthy people, 40 patients with borderline personality disorder, and 26 patients with attention-deficit/hyperactivity disorder (ADHD) who underwent a comprehensive impulsivity test battery including the Barratt Impulsiveness Scale (BIS), UPPS-P Impulsive Behavior Scale, a Go-NoGo task, a stop-signal task, and a delay discounting task. Results: A CFA model comprising three self-reported and three behavioral latent variables reached a good fit. Both patient groups scored higher in the self-reported dimensions and impulsive choice; only the ADHD patients displayed impaired waiting and stopping impulsivity. Conclusions: Using the developed CFA model, it is possible to describe relations between impulsivity dimensions and show different impulsivity patterns in patient populations.

scholarly journals Cognitive Modeling Suggests That Attentional Failures Drive Longer Stop-Signal Reaction Time Estimates in Attention Deficit/Hyperactivity Disorder

2019 ◽  
Vol 7 (4) ◽  
pp. 856-872 ◽  
Author(s):  
Alexander Weigard ◽  
Andrew Heathcote ◽  
Dóra Matzke ◽  
Cynthia Huang-Pollock
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Reaction Time ◽  
Attention Deficit ◽  
Cognitive Modeling ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Unbiased Estimation ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Stop Signal Reaction Time

Mean stop-signal reaction time (SSRT) is frequently employed as a measure of response inhibition in cognitive neuroscience research on attention deficit/hyperactivity disorder (ADHD). However, this measurement model is limited by two factors that may bias SSRT estimation in this population: (a) excessive skew in “go” RT distributions and (b) trigger failures, or instances in which individuals fail to trigger an inhibition process in response to the stop signal. We used a Bayesian parametric approach that allows unbiased estimation of the shape of entire SSRT distributions and the probability of trigger failures to clarify mechanisms of stop-signal task deficits in ADHD. Children with ADHD displayed greater positive skew than their peers in both go RT and SSRT distributions. However, they also displayed more frequent trigger failures, which appeared to drive ADHD-related stopping difficulties. Results suggest that performance on the stop-signal task among children with ADHD reflects impairments in early attentional processes, rather than inefficiency in the stop process.

Cool and hot executive function in conduct-disordered adolescents with and without co-morbid attention deficit hyperactivity disorder: relationships with externalizing behaviours

2013 ◽  
Vol 43 (11) ◽  
pp. 2427-2436 ◽  
Author(s):  
M. Dolan ◽  
C. Lennox
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Executive Function ◽  
Attention Deficit ◽  
Poor Performance ◽  
Delay Of Gratification ◽  
Exact Nature ◽  
Adhd Group ◽  
Behavioural Inhibition ◽  
Hyperactivity Disorder ◽  
Co Morbidity

BackgroundAn understanding of the exact nature of executive function (EF) deficits in conduct disorder (CD) remains elusive because of issues of co-morbidity with attention deficit hyperactivity disorder (ADHD).MethodSeventy-two adolescents with CD, 35 with CD + ADHD and 20 healthy controls (HCs) were assessed on a computerized battery of putative ‘cool’ and ‘hot’ EFs. Participants also completed the Child Behaviour Checklist (CBCL).ResultsIn the cool EF tasks such as planning, the CD + ADHD group in particular showed most notable impairments compared to HCs. This pattern was less evident for set shifting and behavioural inhibition but there were significant correlations between errors scores on these tasks and indices of externalizing behaviours on the CBCL across the sample. For hot EF tasks, all clinical groups performed worse than HCs on delay of gratification and poor performance was correlated with externalizing scores. Although there were no notable group differences on the punishment-based card-playing task, there were significant correlations between ultimate payout and externalizing behaviour across groups.ConclusionsOverall, our findings highlight the fact that there may be more common than distinguishing neuropsychological underpinnings to these co-morbid disorders and that a dimensional symptom-based approach may be the way forward.

scholarly journals Impulsivity in Cocaine-Dependent Individuals with and without Attention-Deficit/Hyperactivity Disorder

2015 ◽  
Vol 21 (3) ◽  
pp. 131-143 ◽  
Author(s):  
Laura Stevens ◽  
Herbert Roeyers ◽  
Geert Dom ◽  
Leen Joos ◽  
Wouter Vanderplasschen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Future Orientation ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Adhd Diagnosis ◽  
Hyperactivity Disorder ◽  
Trait Impulsivity ◽  
Information Sampling ◽  
The Impact

Background: Cocaine-dependent individuals (CDI) display increased impulsivity. However, despite its multifactorial nature most studies in CDI have treated impulsivity monolithically. Moreover, the impact of attention-deficit/hyperactivity disorder (ADHD) has often not been taken into account. This study investigates whether CDI with ADHD (CDI+ADHD) differ from CDI without an ADHD diagnosis and healthy controls (HC) on several impulsivity measures. Methods: Thirty-four CDI, 25 CDI+ADHD and 28 HC participated in this study. Trait impulsivity was assessed with the motor, attentional and non-planning subscales of the Barratt Impulsiveness Scale (BIS-11). Neurocognitive dimensions of impulsivity were examined with the stop signal task (SST), delay discounting task (DDT) and information sampling task (IST). Results: Relative to HC, both CDI and CDI+ADHD scored higher on all BIS-11 subscales, required more time to inhibit their responses (SST) and sampled less information before making a decision (IST). Greater discounting of delayed rewards (DDT) was only found among CDI+ADHD. Compared to CDI without ADHD, CDI+ADHD scored higher on the BIS-11 non-planning and total scale and showed higher discounting rates. Conclusion: CDI score higher on several indices of impulsivity relative to HC, regardless of whether they have concomitant ADHD or not. CDI+ADHD are specifically characterized by a lack of future orientation compared to CDI without ADHD.

scholarly journals Computer-based inhibitory control training in children with Attention-Deficit/Hyperactivity Disorder (ADHD): Evidence for behavioral and neural impact

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241352
Author(s):  
Kristin N. Meyer ◽  
Rosario Santillana ◽  
Brian Miller ◽  
Wes Clapp ◽  
Marcus Way ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Inhibitory Control ◽  
Attention Deficit ◽  
Psychological Disorder ◽  
Stop Signal Task ◽  
Control Group ◽  
Children With Adhd ◽  
Theta Power ◽  
Hyperactivity Disorder ◽  
Computerized Training

Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed psychological disorder of childhood. Medication and cognitive behavioral therapy are effective treatments for many children; however, adherence to medication and therapy regimens is low. Thus, identifying effective adjunct treatments is imperative. Previous studies exploring computerized training programs as supplementary treatments have targeted working memory or attention. However, many lines of research suggest inhibitory control (IC) plays a central role in ADHD pathophysiology, which makes IC a potential intervention target. In this randomized control trial (NCT03363568), we target IC using a modified stop-signal task (SST) training designed by NeuroScouting, LLC in 40 children with ADHD, aged 8 to 11 years. Children were randomly assigned to adaptive treatment (n = 20) or non-adaptive control (n = 20) with identical stimuli and task goals. Children trained at home for at least 5 days a week (about 15m/day) for 4-weeks. Relative to the control group, the treatment group showed decreased relative theta power in resting EEG and trending improvements in parent ratings of attention (i.e. decreases in inattentive behaviors). Both groups showed improved SST performance. There was not evidence for treatment effects on hyperactivity or teacher ratings of symptoms. Results suggest training IC alone has potential to positively impact symptoms of ADHD and provide evidence for neural underpinnings of this impact (change in theta power; change in N200 latency). This shows promising initial results for the use of computerized training of IC in children with ADHD as a potential adjunct treatment option for children with ADHD.

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