scholarly journals Computer-based inhibitory control training in children with Attention-Deficit/Hyperactivity Disorder (ADHD): Evidence for behavioral and neural impact

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241352
Author(s):  
Kristin N. Meyer ◽  
Rosario Santillana ◽  
Brian Miller ◽  
Wes Clapp ◽  
Marcus Way ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Inhibitory Control ◽  
Attention Deficit ◽  
Psychological Disorder ◽  
Stop Signal Task ◽  
Control Group ◽  
Children With Adhd ◽  
Theta Power ◽  
Hyperactivity Disorder ◽  
Computerized Training

Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed psychological disorder of childhood. Medication and cognitive behavioral therapy are effective treatments for many children; however, adherence to medication and therapy regimens is low. Thus, identifying effective adjunct treatments is imperative. Previous studies exploring computerized training programs as supplementary treatments have targeted working memory or attention. However, many lines of research suggest inhibitory control (IC) plays a central role in ADHD pathophysiology, which makes IC a potential intervention target. In this randomized control trial (NCT03363568), we target IC using a modified stop-signal task (SST) training designed by NeuroScouting, LLC in 40 children with ADHD, aged 8 to 11 years. Children were randomly assigned to adaptive treatment (n = 20) or non-adaptive control (n = 20) with identical stimuli and task goals. Children trained at home for at least 5 days a week (about 15m/day) for 4-weeks. Relative to the control group, the treatment group showed decreased relative theta power in resting EEG and trending improvements in parent ratings of attention (i.e. decreases in inattentive behaviors). Both groups showed improved SST performance. There was not evidence for treatment effects on hyperactivity or teacher ratings of symptoms. Results suggest training IC alone has potential to positively impact symptoms of ADHD and provide evidence for neural underpinnings of this impact (change in theta power; change in N200 latency). This shows promising initial results for the use of computerized training of IC in children with ADHD as a potential adjunct treatment option for children with ADHD.

scholarly journals Cognitive Modeling Suggests That Attentional Failures Drive Longer Stop-Signal Reaction Time Estimates in Attention Deficit/Hyperactivity Disorder

2019 ◽  
Vol 7 (4) ◽  
pp. 856-872 ◽  
Author(s):  
Alexander Weigard ◽  
Andrew Heathcote ◽  
Dóra Matzke ◽  
Cynthia Huang-Pollock
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Reaction Time ◽  
Attention Deficit ◽  
Cognitive Modeling ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Unbiased Estimation ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Stop Signal Reaction Time

Mean stop-signal reaction time (SSRT) is frequently employed as a measure of response inhibition in cognitive neuroscience research on attention deficit/hyperactivity disorder (ADHD). However, this measurement model is limited by two factors that may bias SSRT estimation in this population: (a) excessive skew in “go” RT distributions and (b) trigger failures, or instances in which individuals fail to trigger an inhibition process in response to the stop signal. We used a Bayesian parametric approach that allows unbiased estimation of the shape of entire SSRT distributions and the probability of trigger failures to clarify mechanisms of stop-signal task deficits in ADHD. Children with ADHD displayed greater positive skew than their peers in both go RT and SSRT distributions. However, they also displayed more frequent trigger failures, which appeared to drive ADHD-related stopping difficulties. Results suggest that performance on the stop-signal task among children with ADHD reflects impairments in early attentional processes, rather than inefficiency in the stop process.

scholarly journals Correlation between sleep disorder screening and executive dysfunction in children with attention deficit-hyperactivity disorder

2013 ◽  
Vol 71 (11) ◽  
pp. 896-901 ◽  
Author(s):  
Elizabeth Zambrano-Sanchez ◽  
Jose A. Martinez-Cortes ◽  
Minerva Dehesa-Moreno ◽  
Yolanda del Rio-Carlos ◽  
Adrian Poblano
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Working Memory ◽  
Attention Deficit ◽  
Executive Dysfunction ◽  
Group Method ◽  
Control Group ◽  
Intelligence Scale ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Pediatric Sleep Questionnaire

Objective To compare frequency of sleep disorders (SD) and executive dysfunction (ED) in children with attention deficit-hyperactivity disorder (ADHD) and a control group. Method We studied 156 children with ADHD with a mean age of 8.5 years, and a control group with 111 children with a mean age of 8.3 years. We utilized the Pediatric Sleep Questionnaire (PSQ) to screen SD and the working memory measurement from the Wechsler intelligence scale for children (WISC-IV) to screen ED. Results We did not observe an increased frequency of SD in children with ADHD compared with the controls. However, we did identify ED in children with ADHD; additionally a significant correlation was observed between the type of ADHD and SD and among ED, WISC-IV measurements, and type of SD in children with ADHD. Conclusion An increase of SD frequency in children with ADHD was not observed, but we did identify ED in children with ADHD. Additionally, a correlation among ADHD types, SD, ED, and WISC-IV measurements was observed in children with ADHD.

C-43 The Relation Between Executive Functioning and Fluid Reasoning Performance in Children with Attention-Deficit/Hyperactivity Disorder

2019 ◽  
Vol 34 (6) ◽  
pp. 1072-1072
Author(s):  
N Coultis ◽  
A Brown ◽  
E Heideman
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Executive Functioning ◽  
Inhibitory Control ◽  
Attention Deficit ◽  
Performance Test ◽  
Word Identification ◽  
Neurodevelopmental Disorder ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Fluid Reasoning

Abstract Objective Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects about 5% of school-aged children.4 Fluid reasoning (FR) tasks assess one’s ability to detect underlying conceptual relationships and use reasoning to identify and apply rules to problem solve.4 Previous research has demonstrated that children with ADHD perform more poorly in FR, though the mechanism behind this is unclear.3,4 The literature suggests that FR is reliant on executive functioning skills such as inhibitory control, working memory, and planning.1,4 Therefore, this study examines how performance on FR from the Wechsler Intelligence Scale for Children (WISC-V) is related to measures of executive functioning (EF) and attention in children with ADHD. Method Participants were children aged 8 to 16-years with ADHD (N = 75) referred for neuropsychological testing. Participant demographics: males (N = 50, 65.8%), females (N = 26, 34.2%); African American (5.3%), Asian (1.3%), Caucasian (52.6%), Other (39.5%). Measures included the WISC-V Fluid Reasoning Index (FRI), Delis-Kaplan Executive Function System (DKEFS) Color Word Identification (CWI) and Tower subtests, omissions/commissions on the Conners Continuous Performance Test (CPT), and Behavior Rating Inventory of Executive Functioning (BRIEF) subscales. Results Bivariate correlations showed that the FRI was only significantly positively correlated with CWI Inhibition/Switching Time (r = .246, p = .047). Commission errors on the CPT approached significance (r = .217, p = .145). Conclusion The WISC-V FRI may be vulnerable to weaknesses in EF or behavioral control in children with ADHD and should be interpreted in that context. Findings suggest the FRI may be particularly impacted by weaknesses in inhibitory control.

An investigation of visuospatial memory impairment in children with attention deficit hyperactivity disorder (ADHD), combined type

2005 ◽  
Vol 35 (10) ◽  
pp. 1433-1443 ◽  
Author(s):  
R. BARNETT ◽  
P. MARUFF ◽  
A. VANCE
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Memory Impairment ◽  
Stimulant Medication ◽  
Memory Task ◽  
Control Group ◽  
Visuospatial Memory ◽  
Careful Study ◽  
Children With Adhd ◽  
Hyperactivity Disorder

Background. Memory impairment is not considered a core cognitive feature of attention deficit hyperactivity disorder, combined type (ADHD-CT), although it is associated with impairments in attentional and executive functions. This study investigates visuospatial memory impairment, in particular encoding and retrieval aspects, in children with ADHD-CT who are stimulant-medication naive and medicated with stimulant medication.Method. A cross-sectional study of visuospatial memory in 6- to 12-year-old children with stimulant-medication-naive ADHD-CT (n=62) and medicated ADHD-CT (n=58) compared to an age- and gender-matched healthy control group (n=39) was completed.Results. Both medication-naive and medicated ADHD-CT groups demonstrated subtle yet significant impairment in visuospatial memory. The memory impairment was delay-independent, which, along with other factors, suggest dysfunction of the encoding rather than retrieval phase of visuospatial memory.Conclusions. Careful study of large ADHD-CT samples does detect deficits in a visuospatial memory task, but these reflect attentional deficits rather than being specifically due to dysfunction of the medial temporal lobe explicit memory system. Children with ADHD-CT may benefit from cognitive and behavioural strategies focused on improving encoding of relevant information rather than retrieval strategies.

scholarly journals Eye-Tracking Training Improves Inhibitory Control in Children with Attention-Deficit/Hyperactivity Disorder

2021 ◽  
Vol 11 (3) ◽  
pp. 314
Author(s):  
Tsz Lok Lee ◽  
Michael K. Yeung ◽  
Sophia L. Sze ◽  
Agnes S. Chan
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Eye Tracking ◽  
Inhibitory Control ◽  
Attention Deficit ◽  
Incongruent Condition ◽  
Control Group ◽  
Hyperactivity Disorder ◽  
Adhd Children ◽  
Common Sign ◽  
Experimental Group

Disinhibition is a common sign among children with attention-deficit/hyperactivity disorder (ADHD). The present study examined the effect of computerized eye-tracking training to improve inhibitory control in ADHD children. Thirty-two ADHD children (mean age = 8.4 years) were recruited. Half of the participants underwent 240 min of eye-tracking training over two weeks (i.e., experimental group), while the other half did not receive any training (i.e., control group). After training, the experimental group exhibited significant improvements in neuropsychological tests of inhibition, such as faster reaction time in the incongruent condition of the Flanker test, more unique designs in the Category Fluency and Five-Point Tests, and a faster completion time in Trail 2 of the Children’s Color Trail Test. The control group did not show significant changes in any of these tests. Our findings support the use of eye-tracking training to improve the inhibitory control of ADHD children.

scholarly journals Computerized Eye-Tracking Training Improves the Saccadic Eye Movements of Children with Attention-Deficit/Hyperactivity Disorder

2020 ◽  
Vol 10 (12) ◽  
pp. 1016
Author(s):  
Tsz Lok Lee ◽  
Michael K. Yeung ◽  
Sophia L. Sze ◽  
Agnes S. Chan
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Eye Movements ◽  
Eye Tracking ◽  
Attention Deficit ◽  
Saccadic Eye Movements ◽  
Saccade Latency ◽  
Pharmacological Intervention ◽  
Control Group ◽  
Children With Adhd ◽  
Hyperactivity Disorder

Abnormal saccadic eye movements, such as longer anti-saccade latency and lower pro-saccade accuracy, are common in children with attention-deficit/hyperactivity disorder (ADHD). The present study aimed to investigate the effectiveness of computerized eye-tracking training on improving saccadic eye movements in children with ADHD. Eighteen children with ADHD (mean age = 8.8 years, 10 males) were recruited and assigned to either the experimental (n = 9) or control group (n = 9). The experimental group underwent an accumulated 240 min of eye-tracking training within two weeks, whereas the control group engaged in web game playing for the same amount of time. Saccadic performances were assessed using the anti- and pro-saccade tasks before and after training. Compared to the baseline, only the children who underwent the eye-tracking training showed significant improvements in saccade latency and accuracy in the anti- and pro-saccade tasks, respectively. In contrast, the control group exhibited no significant changes. These preliminary findings support the use of eye-tracking training as a safe non-pharmacological intervention for improving the saccadic eye movements of children with ADHD.

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

2006 ◽  
Vol 21 (8) ◽  
pp. 544-547 ◽  
Author(s):  
Marijn Lijffijt ◽  
J. Leon Kenemans ◽  
Annemiek ter Wal ◽  
Elise H. Quik ◽  
C. Kemner ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Inhibitory Control ◽  
Attention Deficit ◽  
Task Difficulty ◽  
Linear Trend ◽  
Control Measures ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Subject Design ◽  
Change Task

AbstractPurposeThe effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.Subjects and methodsFifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.ResultsLinear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.Discussion and conclusionIn children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Caries Experience Associated with Attention – Deficit / Hyperactivity Disorder

2006 ◽  
Vol 30 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Michael Todd Grooms ◽  
Martha Ann Keels ◽  
Michael Roberts ◽  
F. Thomas McIver
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Caries Experience ◽  
Control Group ◽  
Daily Routine ◽  
Healthy Children ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
Whole Saliva ◽  
Significant Difference

The purpose of this cross-sectional study was to examine whether children with attention-deficit / hyperactivity disorder (ADHD) had a total caries experience that was equivalent to children without the disorder. Methods: The test sample included children ages 6 to 10 years old diagnosed with ADHD by physicians at Duke University Medical Center. The control group also included healthy children 6 to 10 years old without the diagnosis of ADHD.A visual dental exam for caries was performed and a sample of whole, unstimulated saliva was collected. The parent / guardian of each participant completed a health/medication history and a questionnaire concerning the child's oral health and habits, daily routine, and demographic information. Results: Wilcoxon and chi-square tests showed that children with ADHD have significantly more enamel caries in the primary and permanent dentitions and a significantly higher prevalence of total caries experience when compared to controls. There was no significant difference in whole saliva production between the ADHD children and the controls. Conclusions: Dentists should be aware that children with ADHD are at higher risk for caries.

scholarly journals Fine motor deficits and attention deficit hyperactivity disorder in primary school children

2019 ◽  
Vol 25 ◽  
Author(s):  
Maria Mokobane ◽  
Basil J. Pillay ◽  
Anneke M. Meyer
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Primary School ◽  
Motor Skills ◽  
School Children ◽  
Attention Deficit ◽  
Primary School Children ◽  
Fine Motor ◽  
Control Group ◽  
Children With Adhd ◽  
Hyperactivity Disorder

Background: Many children with attention deficit hyperactivity disorder (ADHD) display motor deficiencies during their daily routine, which may have impact on their developmental course. Children with ADHD who experience motor deficiencies often display deficits in tasks requiring movements, such as handwriting.Aim: This study investigated deficiencies in fine motor skills in primary school children with ADHD. The study further sought to establish whether ADHD subtypes differ in deficiencies of fine motor performance, recorded for both the dominant and non-dominant hands.Methods: The Disruptive Behavior Disorders Rating Scale, completed by educators and parents, was used to screen for ADHD symptoms. Researchers confirmed the diagnosis of ADHD. Motor functioning was assessed using the Grooved Pegboard and Maze Coordination. The children diagnosed with ADHD were matched for age and gender with controls without ADHD. The sample consisted of an ADHD group (160) and control group (160) of primary school children from the Moletjie area.Results: Children with ADHD (predominantly inattentive subtype) and ADHD (combined subtype) performed significantly more poorly than the control group on the Grooved Pegboard (p < 0.05) with both the dominant and non-dominant hand. No significant difference between the hyperactivity and impulsiveness subtype and the controls were found. There was no difference on the Maze Coordination Task (p > 0.05) between the ADHD subtypes and the controls.Conclusion: Difficulties in fine motor skills are prevalent in children with ADHD, particularly in the ADHD-PI and ADHD-C. Problems are encountered in distal, complex, speeded tasks. The effect may lead to poor handwriting and academic performance.

Sign in / Sign up

Export Citation Format

Share Document