scholarly journals Y-chromosomal DNA polymorphism in mouse inbred strains

1987 ◽  
Vol 50 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Yutaka Nishioka
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Dna Polymorphism ◽  
Inbred Strains ◽  
Laboratory Mice ◽  
Wild Populations ◽  
Chromosomal Dna ◽  
Mus Musculus Musculus

SummaryMice are the most widely used experimental mammals, and many inbred strains are available. However, except for the relatively recent strains derived from known wild populations, the relationships between wild and laboratory mice are not well understood. Based on the Y-chromosomal restriction fragmentlength polymorphism, seventeen inbred strains were classified into two groups: strains with the Mus musculus musculus type Y chromosome and those with the M. m. domesticus type Y chromosome. We extended the survey to an additional twenty-two inbred strains. The M. m. musculus type Y chromosome was found in AEJ/GnLe, AAU/SsJ, BDP/J, BXSB/MpJ, DA/HuSn, HTG/GoSfSn, I/LnJ, LP/J, NZW/LacJ, RIIIS/J, SB/Le, SEA/GnJ, SF/CamEi, SK/CamEi, SM/J, WB/ReJ, WC/ReJ and YBR/Ei, while the M. m. domesticus type Y chromosome was present in BUB/BnJ, MA/MyJ, PL/J and ST/bJ.

The Mus musculus domesticus Tdy allele acts later than the Mus musculus musculus Tdy allele: a basis for XY sex-reversal in C57BL/6-YPOS mice

Development ◽  
1991 ◽  
Vol 113 (2) ◽  
pp. 709-714 ◽  
Author(s):  
S.J. Palmer ◽  
P.S. Burgoyne
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Limb Development ◽  
Inbred Strains ◽  
Testicular Development ◽  
Mus Musculus Domesticus ◽  
Mus Musculus Musculus ◽  
Testicular Differentiation ◽  
Allelic Differences ◽  
Xy Sex Reversal

Consomic C57BL/6 males, carrying either the Mus musculus musculus-derived C57BL/6 Y chromosome or the Mus musculus domesticus-derived Poschiavinus Y chromosome, were outcrossed to females of the inbred strains C3H/Bi and CXBH/By and to females of the random bred strain MF1/Ola. In a study at 12.5 days post coitum, gonads of XYC57 and XYPOS fetuses were assessed for the presence of testicular cords. It was found that XYPOS fetuses had a later onset of testicular development than XYC57 fetuses. Limb development, which was monitored as a measure of overall development, was unaffected by the strain of Y present. These data were supported by a longitudinal study in which the increased growth rate of the testes relative to undifferentiated gonads, was also shown to be delayed in XYPOS fetuses. The extent of the delay was estimated to be approximately 14 h. It is concluded that this delay in the onset of testicular differentiation must be caused by differences between the two Y-chromosome types, most probably allelic differences in the testis determinant Tdy.

X-Y chromosome dissociation in wild derived Mus musculus subspecies, laboratory mice, and their Fi hybrids

1982 ◽  
Vol 34 (3) ◽  
pp. 241-252 ◽  
Author(s):  
Y. Matsuda ◽  
H.T. Imai ◽  
K. Moriwaki ◽  
K. Kondo ◽  
F. Bonhomme
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Laboratory Mice

Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome

Nature ◽  
1985 ◽  
Vol 315 (6014) ◽  
pp. 70-72 ◽  
Author(s):  
C. E. Bishop ◽  
P. Boursot ◽  
B. Baron ◽  
F. Bonhomme ◽  
D. Hatat
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Laboratory Mouse ◽  
Mouse Strains ◽  
Mus Musculus Domesticus ◽  
Mus Musculus Musculus

scholarly journals The Mus musculus musculus type Y chromosome predominates in Asian house mice

1987 ◽  
Vol 50 (3) ◽  
pp. 195-198 ◽  
Author(s):  
Yutaka Nishioka ◽  
Estelle Lamothe
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Repetitive Sequence ◽  
House Mice ◽  
Jackson Laboratory ◽  
Mus Musculus Musculus

SummaryUsing a mouse Y chromosomal repetitive sequence that differentiates between the Mus musculus musculus type Y chromosome and the M. m. domesticus type Y chromosome, we studied the Y chromosome in M. m. molossinus, M. m. castaneus and M. m. subspecies specimens recently trapped in Japan, Taiwan and China as well as Asian mice maintained at the Jackson Laboratory and Litton Bionetics. Here we report that the M. m. musculus type Y chromosome predominates in Asian house mice and that Japanese mice maintained at some laboratories may not represent typical M. m. molossinus.

A DNA polymorphism from five inbred strains of the mouse identifies a functional class of domesticus-type Y chromosome that produces the same phenotypic distribution of gonadal hermaphrodites

Genome ◽  
1991 ◽  
Vol 34 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Fred G. Biddle ◽  
Brenda A. Eales ◽  
Yutaka Nishioka
Keyword(s):  
Inbred Strain ◽  
Y Chromosome ◽  
Dna Polymorphism ◽  
Low Frequency ◽  
Inbred Strains ◽  
Functional Class ◽  
Low Frequencies ◽  
Testis Differentiation ◽  
Y Chromosomes ◽  
Functional Classes

The wild-derived CLA inbred strain of the house mouse contains a domesticus-type Y chromosome that lacks a 2.3-kb TaqI band with fragment 1 of the AC11 probe. The CLA Y chromosome also causes a low frequency of XY gonadal hermaphrodites when backcrossed to the C57BL/6J strain (F.G. Biddle and Y. Nishioka. 1988. Genome, 30: 870–878). A similar domesticus-type Y chromosome, lacking the 2.3-kb TaqI band has now been found in the four historical inbred strains AKR/J, MA/MyJ, PL/J, and RF/J. When backcrossed to C57BL/6J, these four Y chromosomes cause low frequencies of gonadal hermaphrodites similar to the CLA Y and phenotypic distributions of types of gonad are indistinguishable from that with the CLA Y. The absence of the 2.3-kb TaqI band appears to be a polymorphism among domesticus-type Y chromosomes that identifies one of the three functional classes that, so far, can be distinguished only by their effects on testis differentiation in backcross test fetuses with the C57BL/6J strain. Three other historical inbred strains, BUB/BnJ, ST/bJ, and SWR/J, with a domesticus-type Y chromosome but containing the 2.3-kb TaqI band, were also assayed. They permit normal testis development in backcross test fetuses with C57BL/6J.Key words: mouse, Y chromosome, gonadal hermaphrodites, primary sex determination.

Analyse génétique de la zone d'hybridation entre les deux sous-espèces de souris Mus musculus domesticus et Mus musculus musculus en Bulgarie

Genome ◽  
1988 ◽  
Vol 30 (3) ◽  
pp. 427-437 ◽  
Author(s):  
Flavie Vanlerberghe ◽  
Pierre Boursot ◽  
Josette Catalan ◽  
Svestoslav Gerasimov ◽  
François Bonhomme ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Y Chromosome ◽  
Hybrid Zone ◽  
Mus Musculus ◽  
Functional Differentiation ◽  
Restriction Pattern ◽  
The Black Sea ◽  
Mus Musculus Domesticus ◽  
The Balkans ◽  
Mus Musculus Musculus

The hybrid zone between the two subspecies of mice Mus musculus domesticus and Mus musculus musculus, which has been studied extensively in Denmark, crosses Europe to the Black Sea through the Alps and the Balkans. Two hundred and seventy-nine animals were captured in 22 localities along a transect across the Balkans. The animals were characterized for seven diagnostic nuclear loci by protein electrophoresis and by restriction pattern analysis of their mitochondrial DNA. The nuclear data show a sharp transition between the two subspecies, most of the variations in allele frequencies (from 0.9 to 0.1) occurring within a 36-km section of the transect. The introgression varies from one locus to the other and is more pronounced, in terms of distance, in M. m. musculus territory. Mitochondrial DNA introgression is important but occurs in one direction only, i.e. from M. m. musculus to M. m. domesticus, while a cytoplasmic transfer from M. m. domesticus to M. m. musculus has been reported. A previous study showed that no Y chromosome introgression occurs. The different behaviour of these three types of markers could be due to the interaction between selection against hybrid genomes and meiotic recombination. Objectively, it would appear that the genes that can introgress are neutral or nearly so and have been separated from deleterious genes they were linked to by recombination. This could explain the differential introgression between autosomal loci. The mitochondrial and Y chromosomes undergo no or very little recombination and each is transmitted as a whole. Their degree of introgression is thus indicative of the intensity of selection resulting from the amount of functional differentiation between the two taxa, which seems to be strong for the Y chromosome and weak for mitochondrial DNA. We propose that the asymmetry of nuclear introgression is due to different population structures. As M. m. musculus is relatively less structured, the rapid spreading of introgressed genes would be favoured. Such a scheme, however, can hardly account for the unidirectionality of the mitochondrial flow, which could be due to sex-dependant behaviour.Key words: mice, hybrid zone, introgression, enzyme polymorphism.

scholarly journals Effect of sperm genotype on chromatid segregation in female mice heterozygous for aberrant chromosome 1

1993 ◽  
Vol 61 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Sergei I. Agulnik ◽  
Igor D. Sabantsev ◽  
Anatoly O. Ruvinsky
Keyword(s):  
Experimental Data ◽  
Mus Musculus ◽  
Meiotic Division ◽  
Chromosome 1 ◽  
Wild Populations ◽  
Aberrant Chromosome ◽  
Female Mice ◽  
Mus Musculus Musculus ◽  
Chromatid Segregation ◽  
Extra Segment

SummaryAn aberrant chromosome 1 with two large homogeneously staining insertions was isolated from wild populations of Mus musculus musculus. The specific features of the aberrant chromosome have been described elsewhere (Agulnik et al. 1990). These include its preferential entry into the oocyte of heterozygous females, increased mortality of homozygotes and decreased fertility of homozygous females. Here we present data indicating that chromatid segregation in heterozygous females depends upon which sperm enters the oocyte before the second meiotic division: meioticdrive is powerful when it is sperm bearing normal chromosome 1, and segregation normalizesduring Mil when it is sperm bearing chromosome 1 with the extra segment. Experimental data are adduced and explanations offered for the observed phenomenon.

Variation of the lumbar vertebrae of mice at two environmental temperatures

Development ◽  
1969 ◽  
Vol 21 (1) ◽  
pp. 97-103
Author(s):  
Kathleen M. H. Munro ◽  
S. A. Barnett
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Environmental Temperature ◽  
Lumbar Vertebrae ◽  
Inbred Strains ◽  
Laboratory Mice ◽  
Maternal Factors ◽  
Breeding Colony ◽  
Environmental Temperatures

The house mouse, Mus musculus L., usually has twenty-six presacral vertebrae: these consist of seven cervical, thirteen thoracic and six lumbar vertebrae (Weber, 1950; Deol, 1958; Berry & Searle, 1963; Berry, 1964). The twenty-sixth vertebra is, however, sometimes abnormal, especially among laboratory mice: on one or both sides it may be fused with the sacrum. There are then five typical lumbar vertebrae, instead of six. The proportion of such abnormalities in a population is influenced by genotype, diet and unidentified maternal factors (reviewed by Grüneberg, 1963). Evidence is given below that a low environmental temperature can also increase the incidence of ‘sacralization of L6’. The mice used included three highly inbred strains: A/Tb, A2G/Tb and C57BL/Tb. A permanent breeding colony of each strain was kept at each of two environmental temperatures, namely, 21 °C and −3 °C. In addition, GFF mice were studied at 21 °C only.

The origin of common laboratory mice

Genome ◽  
1995 ◽  
Vol 38 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yutaka Nishioka
Keyword(s):  
Genomic Dna ◽  
Genetic Data ◽  
Inbred Strains ◽  
Hybrid Origin ◽  
Model Organisms ◽  
Historical Records ◽  
Laboratory Mice ◽  
Wild Populations ◽  
Molecular Studies ◽  
Common Laboratory

The house mouse is one of the model organisms in genetics and more than 400 inbred strains have been established. However, many of the strains are related and their ancestry can be traced back to European fancy mice inbred in the 1920s. Recent molecular studies corroborate the early historical records that assert that Japanese fancy mice were introduced into European stocks and thus contributed to the development of "old" inbred strains. Consequently, many inbred strains have genomic DNA derived from more than one subspecies of Mus musculus. The subspecific hybrid origin of common inbred strains has important bearings on the interpretation of genetic data, and the limitations that history imposes upon the currently available strains make it necessary to establish new inbred strains representing specific wild populations.

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