scholarly journals Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass

2008 ◽  
Vol 90 (3) ◽  
pp. 259-268 ◽  
Author(s):  
JIAN ZHAO ◽  
PENG XIAO ◽  
YAN GUO ◽  
YONG-JUN LIU ◽  
YU-FANG PEI ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Pleiotropic Effects ◽  
Phenotypic Traits ◽  
Body Fat Mass ◽  
Entire Sample ◽  
Total Body ◽  
Genomic Regions

SummaryTotal body fat mass (TBFM) and total body lean mass (TBLM) are the major components of the human body. Although these highly correlated phenotypic traits are frequently used to characterize obesity, the specific shared genetic factors that influence both traits remain largely unknown. Our study was aimed at identifying common quantitative trait loci (QTLs) contributing to both TBFM and TBLM. We performed a whole genome-linkage scan study in a large sample of 3255 subjects from 420 Caucasian pedigrees. Bivariate linkage analysis was carried out in both the entire sample and gender-specific subsamples. Several potentially important genomic regions that may harbour QTLs important for TBFM and TBLM were identified. For example, 20p12-11 achieved a LOD score of 2·04 in the entire sample and, in the male subsample, two genomic regions, 20p12 (LOD=2·08) and 3p26-25 (LOD=1·92), showed suggestive linkage. In addition, two-point linkage analyses for chromosome X showed suggestive linkages on Xp22 in the entire sample (LOD=2·14) and significant linkage on Xp22 in the female subsample (LOD=3·05). Complete pleiotropy was suggested for 20p12 and 3p26-25 in males. Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly influence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed.

Bivariate whole-genome linkage scan for bone geometry and total body fat mass

2009 ◽  
Vol 36 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Shufeng Lei ◽  
Feiyan Deng ◽  
Peng Xiao ◽  
Kai Zhong ◽  
Hongyi Deng ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Bone Geometry ◽  
Body Fat Mass ◽  
Whole Genome ◽  
Total Body Fat ◽  
Total Body

scholarly journals Relationship of total body fat mass to weight-bearing bone volumetric density, geometry, and strength in young girls

Bone ◽  
2010 ◽  
Vol 46 (4) ◽  
pp. 977-984 ◽  
Author(s):  
Joshua N. Farr ◽  
Zhao Chen ◽  
Jeffrey R. Lisse ◽  
Timothy G. Lohman ◽  
Scott B. Going
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Weight Bearing ◽  
Body Fat Mass ◽  
Volumetric Density ◽  
Young Girls ◽  
Total Body Fat ◽  
Total Body ◽  
Bone Volumetric Density ◽  
Relationship Of

scholarly journals Impact of a lignan-rich diet on adiposity and insulin sensitivity in post-menopausal women

2009 ◽  
Vol 102 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Anne-Sophie Morisset ◽  
Simone Lemieux ◽  
Alain Veilleux ◽  
Jean Bergeron ◽  
S. John Weisnagel ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Body Fat ◽  
Fat Mass ◽  
Metabolic Profile ◽  
Body Fat Mass ◽  
Dietary Record ◽  
Menopausal Women ◽  
Total Body Fat ◽  
Total Body ◽  
Post Menopausal

There has been a growing interest in lignans, a class of phyto-oestrogens, because of their potentially favourable effects on human health. The aim of the present study was to compare the metabolic profile of post-menopausal women consuming various amounts of dietary lignans. Phyto-oestrogen intake was assessed using a 3-d dietary record analysed with a Canadian food phyto-oestrogen content data table in 115 post-menopausal women (age 56·8 (sd 4·4) years and BMI 28·5 (sd 5·9) kg/m2). Plasma enterolactone (ENL), the major biologically active metabolite of dietary lignans, was determined by time-resolved fluoroimmunoassay. Anthropometrics, abdominal adipose tissue areas (computed tomography), body composition (hydrostatic weighing) and insulin sensitivity (hyperinsulinaemic–euglycaemic clamp) were measured in all women. Women in the high dietary lignan intake subgroup (n 29) had a significantly lower BMI and total body fat mass, as well as a better glucose disposal rate (GDR; P < 0·05), compared with women in the low lignan intake subgroup (n 28). The majority of women with the highest dietary lignan intake were also in the highest quartile of plasma ENL (59 %). Women in the highest ENL quartile had a significantly lower BMI (26·1 (sd 4·4) v. 30·4 (sd 6·9) kg/m2, P < 0·05), total body fat mass (24·8 (sd 9·8) v. 33·3 (sd 13·3) kg, P < 0·05), 2 h postload glycaemia (5·5 (sd 0·9) v. 5·7 (sd 0·8) nmol/l, P < 0·05) and a higher GDR (8·3 (sd 2·7) v. 5·5 (sd 2·8), P < 0·01) compared with women in the lowest ENL quartile. In conclusion, women with the highest ENL concentrations had a better metabolic profile including higher insulin sensitivity and lower adiposity measures.

New equations for estimating body fat mass in pregnancy from body density or total body water

1988 ◽  
Vol 48 (1) ◽  
pp. 24-29 ◽  
Author(s):  
J M van Raaij ◽  
M E Peek ◽  
S H Vermaat-Miedema ◽  
C M Schonk ◽  
J G Hautvast
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Total Body Water ◽  
Body Water ◽  
Body Fat Mass ◽  
Body Density ◽  
Total Body ◽  
In Pregnancy

Hematological changes in anorexia nervosa are correlated with total body fat mass depletion

1997 ◽  
Vol 21 (4) ◽  
pp. 329-334 ◽  
Author(s):  
Michel Lambert ◽  
Catherine Hubert ◽  
Genevi�ve Depresseux ◽  
Bruno Vande Berg ◽  
Jean-Paul Thissen ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Total Body Fat ◽  
Mass Depletion ◽  
Total Body ◽  
Hematological Changes

scholarly journals Body fat mass and lean mass as predictors of survival in hemodialysis patients

2006 ◽  
Vol 70 (3) ◽  
pp. 549-556 ◽  
Author(s):  
R. Kakiya ◽  
T. Shoji ◽  
Y. Tsujimoto ◽  
N. Tatsumi ◽  
S. Hatsuda ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Hemodialysis Patients ◽  
Body Fat Mass

scholarly journals Different body parts’ fat mass and corrected QT interval on the electrocardiogram: The Fasa PERSIAN Cohort Study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohammad Hosein Yazdanpanah ◽  
Ehsan Bahramali ◽  
Mohammad Mehdi Naghizadeh ◽  
Mojtaba Farjam ◽  
Maryam Mobasheri ◽  
...  
Keyword(s):  
Cohort Study ◽  
Body Fat ◽  
Fat Mass ◽  
Qt Interval ◽  
Fat Free Mass ◽  
P Value ◽  
Body Fat Mass ◽  
Qtc Interval ◽  
Body Parts ◽  
Total Body

Abstract Background Previous studies suggested that obesity and fat mass are associated with QT interval prolongation, but the role of different body parts' fat mass is unclear. The associations between total and regional fat mass (FM) and corrected QT interval (QTc) were investigated for the first time in this study. Methods In this sub-analysis of Fasa PERSIAN cohort Study data, 3217 subjects aged 35–70 entered our study. Body fat mass was assessed by bioelectrical impedance analysis and QTc interval calculated by the QT interval measured by Cardiax® software from ECGs and Bazett’s formula. Uni- and multi-variable linear and logistic regression was performed in IBM SPSS Statistics v23. Results In males, the fat mass to fat-free mass (FM/FFM) ratio in the trunk, arms, total body, and legs were significantly higher in the prolonged QTc group (QTc > 450 ms). Trunk (B = 0.148), total (B = 0.137), arms (B = 0.124), legs (B = 0.107) fat mass index (FMI) showed significant positive relationship with continuous QTc (P-value < 0.001). Also, just the fat-free mass index of legs had significant positive associations with QTc interval (P-value < 0.05). Surprisingly, in females, the mean of FM/FFM ratio in trunk and legs in the normal QTc group had higher values than the prolonged QTc group (QTc > 470 ms). Also, none of the body composition variables had a significant correlation with continuous QTc. Conclusion Our study suggested that FMI ratios in the trunk, total body, arms, and legs were positively associated with QTc interval in males, respectively, from a higher to a lower beta-coefficient. Such associations were not seen in females. Our study implies that body fat mass may be an independent risk factor for higher QTc interval and, consequently, more cardiovascular events that should be investigated.

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