scholarly journals Electrophoretic and Immunological Studies on Sera from Calves from Birth to Weaning II. Electrophoretic and Serological Studies with Special Reference to the Normal and Induced Agglutinins to Trichomonas Foetus

1955 ◽  
Vol 53 (3) ◽  
pp. 261-275 ◽  
Author(s):  
A. E. Pierce
Keyword(s):  
Statistical Analysis ◽  
Special Reference ◽  
Early Life ◽  
Normal Adult ◽  
Neonatal Calf ◽  
Serological Studies

Summary1. The lacto-globulin in bovine colostral whey, and the γ globulin in the serum contain the normal and induced agglutinins to the protozoon Trichomonas foetus.2. A decline in γ globulin in sera from cattle approaching calving may be associated with the concentration of the lacto-globulin in the udder.3. The elimination of the passive normal and induced agglutinins acquired by the neonatal calf was logarithmic. The autogenous production of γ globulin by the calf occurred soon after birth, resulting in an apparent decline in the rate of elimination of the lacto-globulins.4. The autogenous production of γ globulin was not necessarily accompanied by that of detectable normal agglutinin.5. Calves injected with T. foetus antigen within the first 3 weeks of life, and in which there was evidence of autogenous γ globulin, developed normal autogenous but not induced agglutinins.6. Calves which received colostrum containing maternal induced and normal agglutinins, calves partially deprived of colostrum, and calves immunized in early life, produced the normal autogenous agglutinin between the 30th and 60th days, reaching the normal adult titre of 1/48–1/96.7. The properties of the normal agglutinins were investigated. They possess some characteristics significantly different from those of the induced agglutinins. These suggested that the normal agglutinins were γ globulin molecules with an ‘accidental’ genetic configuration complementary to T. foetus.The author wishes to thank Dr M. Robertson, F.R.S., and Sir Alan Drury, F.R.S. for their interest and encouragement during the course of this work, and Dr R. C. Campbell for the statistical analysis.

scholarly journals An Accidental Genetic Epidemiologist

2020 ◽  
Vol 21 (1) ◽  
pp. 15-36
Author(s):  
Robert C. Elston
Keyword(s):  
Statistical Analysis ◽  
Association Analysis ◽  
Genetic Epidemiology ◽  
Early Life ◽  
Method Development ◽  
Paternity Testing ◽  
Linkage And Association Analysis ◽  
Computer Package ◽  
Heritability Estimates ◽  
Further Development

I briefly describe my early life and how, through a series of serendipitous events, I became a genetic epidemiologist. I discuss how the Elston–Stewart algorithm was discovered and its contribution to segregation, linkage, and association analysis. New linkage findings and paternity testing resulted from having a genotyping lab. The different meanings of interaction—statistical and biological—are clarified. The computer package S.A.G.E. (Statistical Analysis for Genetic Epidemiology), based on extensive method development over two decades, was conceived in 1986, flourished for 20 years, and is now freely available for use and further development. Finally, I describe methods to estimate and test hypotheses about familial correlations, and point out that the liability model often used to estimate disease heritability estimates the heritability of that liability, rather than of the disease itself, and so can be highly dependent on the assumed distribution of that liability.

scholarly journals L'analisi dei dati nell'indagine statistica. Volume 2

2005 ◽  
Author(s):  
Filomena Maggino
Keyword(s):  
Data Analysis ◽  
Statistical Analysis ◽  
Special Reference ◽  
Social Research ◽  
Data Exploration ◽  
Statistical Approaches ◽  
Methodological Approaches ◽  
Statistical Survey ◽  
Interpretation Of Results

In the sphere of social research, one of the principal methodological approaches is that of the survey. In the performance of surveys, statistics play a fundamental role. This publication is intended to highlight this role, with special reference to data analysis, placing the emphasis on the objectives of such analysis, the logic, the procedures necessary to achieve them, and the interpretation of results. The material has been divided into two volumes, which while being independent are also logically connected. The first volume is organised in two sections: the first is designed to provide a synthetic overview of the statistical survey in terms of methods and instruments, while the second describes the principal instruments of statistical analysis which enable a description of the data. The first volume comes complete with a CD with hypertext. The second volume presents the statistical approaches which enable the achievement of specific objectives, seen in terms of data exploration and verification of the results obtained.

scholarly journals L'analisi dei dati nell'indagine statistica. Volume 1

2005 ◽  
Author(s):  
Filomena Maggino
Keyword(s):  
Data Analysis ◽  
Statistical Analysis ◽  
Special Reference ◽  
Social Research ◽  
Data Exploration ◽  
Statistical Approaches ◽  
Methodological Approaches ◽  
Statistical Survey ◽  
Interpretation Of Results

In the sphere of social research, one of the principal methodological approaches is that of the survey. In the performance of surveys, statistics play a fundamental role. This publication is intended to highlight this role, with special reference to data analysis, placing the emphasis on the objectives of such analysis, the logic, the procedures necessary to achieve them, and the interpretation of results. The material has been divided into two volumes, which while being independent are also logically connected. The first volume is organised in two sections: the first is designed to provide a synthetic overview of the statistical survey in terms of methods and instruments, while the second describes the principal instruments of statistical analysis which enable a description of the data. The first volume comes complete with a CD with hypertext. The second volume presents the statistical approaches which enable the achievement of specific objectives, seen in terms of data exploration and verification of the results obtained.

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