scholarly journals Responses of volunteers to inactivated influenza virus vaccines

1981 ◽  
Vol 86 (1) ◽  
pp. 1-16 ◽  
Author(s):  
R. Jennings ◽  
C. W. Potter ◽  
P. M. O. Massey ◽  
B. I. Duerden ◽  
J. Martin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
New Jersey ◽  
Antibody Response ◽  
Surface Antigen ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine ◽  
Systemic Reactions ◽  
Antigen Vaccine ◽  
Different Types ◽  
Aqueous Surface

SUMMARYThree different types of bivalent influenza virus vaccine, a whole virus, an aqueous-surface-antigen vaccine and an adsorbed-surface-antigen vaccine were tested at three dosage levels in volunteers primed with respect to only one of the haemagglutinin antigens present in the vaccines.The local and systemic reactions to all three vaccine types were mild in nature and, following first immunization, the aqueous-surface-antigen vaccine was the least reactogenic. The serum haemagglutination-inhibiting antibody response to the A/Victoria/75 component of the vaccines, to which the volunteer population was primed, was greatest following immunization with the aqueous-surface-antigen vaccine; the greatest antibody response to the A/New Jersey/76 component of the vaccines was observed following immunization with whole virus vaccine.

scholarly journals A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity

1983 ◽  
Vol 90 (3) ◽  
pp. 351-359 ◽  
Author(s):  
A. Clark ◽  
C. W. Potter ◽  
R. Jennings ◽  
J. P. Nicholl ◽  
A. F. Langrick ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antibody Response ◽  
Surface Antigen ◽  
Influenza A ◽  
Serum Antibody ◽  
H1n1 Influenza ◽  
Live Attenuated Vaccine ◽  
Challenge Virus ◽  
Influenza A H1n1 ◽  
Aqueous Surface

SUMMARYGroups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.

Single-Dose Trials of Monovalent A/New Jersey/76 (Hsw1N1) Influenza Virus Vaccine in Children in Durham, North Carolina

1977 ◽  
Vol 136 (Supplement 3) ◽  
pp. S575-S575 ◽  
Author(s):  
L. T. Gutman ◽  
C. M. Wilfert ◽  
Z. H. Idriss ◽  
E. Schmidt ◽  
S. Andrews ◽  
...  
Keyword(s):  
North Carolina ◽  
Influenza Virus ◽  
Single Dose ◽  
New Jersey ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine

THE ANTIBODY RESPONSE IN MAN TO A QUADRIVALENT INFLUENZA VIRUS VACCINE

1955 ◽  
Vol 1 (4) ◽  
pp. 249-255
Author(s):  
Barbara K. Buchner ◽  
D. B. W. Reid ◽  
G. Dempster
Keyword(s):  
Influenza Virus ◽  
Antibody Response ◽  
Virus Vaccine ◽  
Influenza Virus Vaccine ◽  
The Other ◽  
Type B ◽  
Strain Type ◽  
Antibody Levels ◽  
Subcutaneous Inoculation

The antibody response to the subcutaneous inoculation of a single 1 ml. dose of a quadrivalent formalin-killed influenza virus egg vaccine has been measured. The vaccine used contained two A prime components and an A and a B component. Satisfactory responses were obtained two weeks after inoculation to the A and B components and to one of the A prime strains (FM1). A poor antibody response was noted to the other A prime strain incorporated in the vaccine (FW50). The highest levels were obtained with the Lee strain (Type B) which also stimulated an antibody rise to a recently isolated Type B strain. Antibody levels were maintained for at least 12 weeks. Treatment of the sera with RDE was found to influence the results obtained with the FM1 strain used.

ANTIBODY RESPONSE TO INFLUENZA-VIRUS VACCINE IN CHILDREN WITH NEPHROSIS: EFFECT OF CORTISONE

PEDIATRICS ◽  
1959 ◽  
Vol 23 (1) ◽  
pp. 54-62
Author(s):  
Calvin M. Kunin ◽  
Robert Schwartz ◽  
Sumner Yaffe ◽  
John Knapp ◽  
Francis X. Fellers ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Nephrotic Syndrome ◽  
Antibody Response ◽  
Virus Vaccine ◽  
Influenza A ◽  
Serum Levels ◽  
Influenza Virus Vaccine ◽  
Inactive Disease ◽  
Strain Component ◽  
Adrenogenital Syndrome

Polyvalent influenza-virus vaccine was administered to 55 children; 44 of these children were in various stages of nephrotic syndrome, including 17 under treatment with adrenocortical hormones; 5 were children with the adrenogenital syndrome receiving replacement cortisone therapy, and 6 were normal controls. Antibody response, as measured by the hemagglutination-inhibition test 2 weeks following a single subcutaneous dose of vaccine, was not significantly different in children with active or inactive disease, and appeared to be similar in those receiving hormone therapy and in those who were not. The serum levels of gamma-globulin were lower in children with active nephrotic syndrome, but this did not affect either the prevaccination levels of influenza A prime antibody or the response to the vaccine. No change in the status of activity of nephrosis occurred during the period of immunization or immediately thereafter, even in patients who had moderate febrile reactions to the vaccine. The failure of any of the groups to respond serologically to the Asian strain component of the vaccine is discussed.

scholarly journals Nutritional support improves antibody response to influenza virus vaccine in the elderly.

BMJ ◽  
1985 ◽  
Vol 291 (6505) ◽  
pp. 1348-1349 ◽  
Author(s):  
M Chavance ◽  
B Herbeth ◽  
T Mikstacki ◽  
C Fournier ◽  
G Vernhes ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antibody Response ◽  
Virus Vaccine ◽  
Nutritional Support ◽  
The Elderly ◽  
Influenza Virus Vaccine
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