Foreign body reaction to polymethylsiloxane gel (Bioplastique™) after vocal fold augmentation

2008 ◽  
Vol 122 (7) ◽  
pp. 750-753 ◽  
Author(s):  
P S Randhawa ◽  
A D Ramsay ◽  
J S Rubin
Keyword(s):  
Foreign Body ◽  
Vocal Fold ◽  
Foreign Body Reaction ◽  
Vocal Fold Paralysis ◽  
Tissue Reaction ◽  
Voice Change ◽  
Vocal Fold Augmentation ◽  
Vocal Fold Injection ◽  
Foreign Body Reactions ◽  
And Migration

AbstractStatement of problem:The consequences of vocal fold paralysis include voice change, airway problems and difficulty swallowing. Medialisation procedures using injected material have been used for many decades, with varying outcomes, mainly secondary to lifespan, tissue reaction or migration. Newer materials have recently become clinically available which are easier to manage and supposedly less likely to elicit foreign body reaction.Method of study:Case report.Results:We report a case of foreign body reaction and possible migration of polymethylsiloxane gel (Bioplastique™), one such material, after vocal fold injection. To our knowledge, this is the second such case described.Conclusions:This case highlights the fact that the risk of foreign body reaction and migration is still present for this material, albeit low. We also highlight the fact that, although this material can cause foreign body reactions and may possibly migrate, it is removable by microlaryngoscopy via the microflap technique, with vocal improvement.

Foreign Body Reaction to Calcium Hydroxylapatite Vocal Fold Augmentation

2006 ◽  
Vol 132 (12) ◽  
pp. 1379 ◽  
Author(s):  
Neil Tanna ◽  
Daniel Zalkind ◽  
Robert S. Glade ◽  
Steven A. Bielamowicz
Keyword(s):  
Foreign Body ◽  
Vocal Fold ◽  
Foreign Body Reaction ◽  
Calcium Hydroxylapatite ◽  
Vocal Fold Augmentation

scholarly journals Tissue Reaction of the Rat Urinary Bladder to Synthetic Mesh Materials

2009 ◽  
Vol 9 ◽  
pp. 1046-1051 ◽  
Author(s):  
Gokhan Atis ◽  
Serdar Arisan ◽  
Aysim Ozagari ◽  
Turhan Caskurlu ◽  
Ayhan Dalkilinc ◽  
...  
Keyword(s):  
Foreign Body ◽  
Urinary Bladder ◽  
Foreign Body Reaction ◽  
Bladder Wall ◽  
Synthetic Mesh ◽  
Tissue Reaction ◽  
Collagen Deposition ◽  
Rat Urinary Bladder ◽  
Intravaginal Slingplasty ◽  
Tissue Reactions

The aim of this study was to assess urinary bladder histopathology induced by the sling materials tension-free vaginal tape (TVT), vypro mesh, and intravaginal slingplasty (IVS). Thirty rats were studied: sham-operated controls, TVT, vypro, and IVS groups. After laparotomy, a 0.5- x 1-cm piece of mesh was implanted on the anterior bladder wall. The bladder was examined histopathologically after 12 weeks. Inflammation, foreign-body reaction, subserosal fibrosis, necrosis, and collagen deposition were graded. The Kruskal-Wallis and posthoc Dunn tests were used. The sham-operated rats showed no tissue reactions. The TVT, vypro, and IVS groups showed increased inflammation (p= 0.006,p= 0.031,p= 0.001), subserosal fibrosis (p= 0.0001), foreign-body reaction (p = 0.0001), and collagen deposition (p= 0.0001) as compared to sham. Inflammation was more intense in the IVS group as compared to the TVT and vypro groups (p= 0.041,p= 0.028). The bladder presented more increased inflammatory response to IVS than the other meshs. This may play a role in the ultimate outcomes or complications from slings.

scholarly journals Airway Foreign Body Occurring during In-Office Vocal Fold Injection

2017 ◽  
Vol 96 (3) ◽  
pp. 97-98
Author(s):  
Pamela Chia ◽  
Aaron Jaworek ◽  
Robert T. Sataloff
Keyword(s):  
Foreign Body ◽  
Vocal Fold ◽  
Vocal Fold Injection ◽  
Airway Foreign Body

scholarly journals Bovine Onchocerciasis Caused by Onchocerca armillata and O. gutturosa

1978 ◽  
Vol 15 (4) ◽  
pp. 495-505 ◽  
Author(s):  
A. H. Cheema ◽  
B. Ivoghli
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Plasma Cells ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Foreign Body Reactions ◽  
Gross Lesions ◽  
Acute Changes

Onchocerca armillata was found in 284 (28%) of 1,016 aortas, and O. gutturosa in 82 (28.87%) of 284 nuchal ligaments and in 11 (7.85%) of 140 rumenosplenic areas in specimens from cattle slaughtered during a 12-month period. Adult parasites were not found in 600 hides. Gross lesions included parasitic tunnels, nodules, roughening and calcification in the aortic walls. The connective tissue of nuchal ligaments and rumenosplenic areas was increased in amount, was gelatinous and brown and had a few nodules. Microscopically there were acute changes with oedema, haemorrhages and cellular infiltrations predominantly by eosinophils. There were chronic granulomatous reactions characterized by accumulation of macrophages, lymphocytes, plasma cells, giant cells, calcification and fibrosis around degenerate and dead parasites. Neutral fat was in parasites and surrounding cells. Both changes often occurred in the same specimen and many samples had parasites but no tissue reaction. Hypersensitivity, foreign-body reactions and parasitic toxins apparently were involved in the genesis of these lesions.

Long-term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy

2005 ◽  
Vol 132 (5) ◽  
pp. 685-688 ◽  
Author(s):  
Hisanori Sasai ◽  
Yusuke Watanabe ◽  
Hiroshi Muta ◽  
Junichi Yoshida ◽  
Ibuki Hayashi ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Folds ◽  
Vocal Fold Paralysis ◽  
Histological Evaluation ◽  
Fat Injection ◽  
Special Equipment ◽  
Autologous Fat ◽  
Vocal Fold Augmentation ◽  
Disposable Needle

OBJECTIVE: To histologically evaluate the long-term outcomes of autologous fat grafts after injection laryngoplasty in the human larynx. STUDY DESIGN AND SETTING: We injected liposuctioned fat for vocal fold augmentation in patients with vocal fold paralysis. We suctioned autologous fat from the low abdomen with an 18-G disposable needle and a 20-mL disposable syringe under negative pressure. This is different from the conventional liposuction technique and avoids the use of special equipment. In this article, we report the histological evaluation of 2 patients (patient 1: 12 months, patient 2: 41 months) who required total laryngectomy after autologous fat injection into the vocal folds. RESULTS: Histological examination revealed normal-appearing viable adipocytes with minimal inflammatory response in both patients. CONCLUSIONS: Our liposuctioned autologous fat injection histologically offered long-term improvement in patients with impaired glottal closure from vocal fold paralysis. (Otolaryngol Head Neck Surg 2005;132:685-688.)

Epidermal inclusion cysts following minimal incision surgery

1992 ◽  
Vol 82 (10) ◽  
pp. 537-541 ◽  
Author(s):  
AK Farrer ◽  
WM Forman ◽  
AM Boike
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Epidermal Cells ◽  
Epidermal Cyst ◽  
Drill Bit ◽  
Direct Visualization ◽  
Minimal Incision ◽  
Foreign Body Reactions ◽  
High Degree ◽  
Heat Buildup

One of the most frequent causes of epidermal inclusion cysts is trauma involving the epidermis with subsequent implantation of epidermal cells into the dermis or subcutis. Minimal incision surgery is capable of achieving this because it is performed by using small incisions and rapidly rotating power instruments. The technique requires that the surgeon master a high degree of dexterity and knowledge of the anatomy without the aid of direct visualization. Van Enoo and Cane suggest the use of fresh, sharp skin blades to protect against invagination of skin edges which could lead to epidermal inclusion cysts. They also state that an improper position or an incision that is too small will cause tension, which can lead to heat buildup with subsequent sloughing and dehiscence. It may also drive some epidermal cells underneath the dermis and foster an epidermal cyst. Other surgeons using small incisions suggest thorough and copious irrigation to flush away debris and to avoid potential foreign body reactions. The periosteum should be reflected away from the point where the drill bit exits the bone to prevent bone chips from being forced subperiosteally and potentially causing a foreign body reaction. By virtue of the technique, minimal incision surgery lends itself to a greater risk of causing epidermal inclusion cysts. Surgeons who use these techniques must be aware of this potential complication.

Posterior glottic gap and age as factors predicting voice outcome of injection laryngoplasty in patients with unilateral vocal fold paralysis

2011 ◽  
Vol 126 (3) ◽  
pp. 260-266 ◽  
Author(s):  
J Choi ◽  
Y-I Son ◽  
Y K So ◽  
H Byun ◽  
E-K Lee ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Favourable Outcome ◽  
Injection Laryngoplasty ◽  
Unilateral Vocal Fold Paralysis ◽  
Demographic Profiles ◽  
Bovine Collagen ◽  
Vocal Fold Augmentation ◽  
Collagen Injection ◽  
Voice Outcome

AbstractObjectives:This study aimed to analyse demographic profiles and pre-injection stroboscopic findings for patients with unilateral vocal fold paralysis, to investigate possible predictive factors for voice outcomes of injection laryngoplasty.Materials and methods:Fifty-nine unilateral vocal fold paralysis patients underwent vocal fold augmentation, using transcutaneous Artecoll (polymethyl methacrylate microspheres plus bovine collagen) injection into the paralysed vocal fold via the cricothyroid space. Three months later, patients were divided into improved (n = 44) and unimproved (n = 15) groups, using the perceptual grade-roughness-breathiness-asthenia-strain scale, and their clinical characteristics and pre-operative stroboscopic findings compared.Results:The improved group were significantly younger than the unimproved group (p = 0.000). The size of the posterior gap on phonation was closely associated with the outcome of injection laryngoplasty (p = 0.015).Conclusion:Younger patients with a smaller posterior glottic gap on phonation can be expected to have a more favourable outcome following injection laryngoplasty for correction of glottic insufficiency due to unilateral vocal fold paralysis.

Use of polyethylene terephthalate and expanded-polytetrafluoroethylene in medialization laryngoplasty

2003 ◽  
Vol 117 (4) ◽  
pp. 294-297 ◽  
Author(s):  
Gürkan Keskin ◽  
Zerrin Boyaci ◽  
Emre Ustundag ◽  
Ahmet Kaur ◽  
Ahmet Almaç
Keyword(s):  
Foreign Body ◽  
Polyethylene Terephthalate ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Foreign Body Giant Cell ◽  
Expanded Polytetrafluoroethylene ◽  
Vocal Fold Augmentation ◽  
Foreign Body Giant Cells ◽  
Local Host ◽  
Medialization Laryngoplasty

Various materials have been used up to the present time in vocal fold augmentation. Although silicon has been the most frequently employed, the surgical difficulties encountered in shaping, positioning and placing this material have led to a search for a more easily applicable material. In our study, we investigated the local tissue reaction to implants in the laryngeal skeleton of 10 New Zealand rabbits in which we performed medialization laryngoplasty employing polyethylene terephthalate (PETP = Dacron®) and expanded polytetrafluoroethylene (e-PTFE = Gore-Tex®). When the local host tissue reaction to PETP and e-PTFE were compared, PETP was found to cause significant foreign body giant cell and histiocyte infiltration localized around fibres of the implant. The greater irregularity of the fibrous capsule formed in response to PETP and the density of foreign body giant cells around the PETP fibres suggested that resorption of the implant with time would decrease the degree of medialization.

A Poly-Chitosan and Cis-Platinum Conjugated Composite Nanoparticle System for Liver Cancer Therapy

2021 ◽  
Vol 17 (9) ◽  
pp. 1726-1734
Author(s):  
Xiangyu Fan ◽  
Haiyun Wu ◽  
Lisong Zhao ◽  
Xu Guo
Keyword(s):  
Foreign Body ◽  
Liver Cancer ◽  
Foreign Body Reaction ◽  
Tumor Therapy ◽  
Carcinoma Cells ◽  
Tumor Diameter ◽  
Foreign Body Reactions ◽  
Nanoparticle System ◽  
Diameter Reduction ◽  
Macrophage Reaction

The aim of this study was to test an effective nano-pole capsule loaded cis-platinum (CP) transplantation device for liver cancer (LC) therapy. A novel nano-pole capsule was designed as a new vector for storing CP. HepG2 cells and a B6/J mouse model were used to test the efficiency of polyethyleneimine-cis-platinum (PEI-CP) and poly-chitosan-cis-platinum (PC-CP). Infiltration efficiency and transplantation efficiency tests were performed to study the performance of the delivery system, and fibroblast reactions and macrophage numbers were observed, to test for immune rejection and foreign body reactions. The apoptosis rate and tumor diameter of hepatocellular carcinoma cells were used to evaluate the effect of the tumor therapy. We also studied the functional mechanism of different CP delivery systems. The infiltration and transplantation efficiencies of PC-CP were higher than that of PEI-CP; Less foreign body reaction appeared in PC system, with less fibroblast reaction and lower macrophage reaction. The clinical efficacy of PC-CP in terms of tumor apoptosis and diameter reduction was superior to that of PEI-CP. We demonstrated that PC-CP had a more significant alteration effect on mTOR, P-Ak, LC3 and P53. The PC system can better deliver and release drugs than PEI-CP, and may be a better choice for LC therapy in the future.

scholarly journals Local Foreign-Body Reaction to Commercial Biodegradable Implants: An in Vivo Animal Study

2014 ◽  
Vol 7 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Amy S. Xue ◽  
John C. Koshy ◽  
William M. Weathers ◽  
Erik M. Wolfswinkel ◽  
Yoav Kaufman ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Close Association ◽  
Inflammatory Cells ◽  
Giant Cells ◽  
Inflammatory Reactions ◽  
Debris Accumulation ◽  
Foreign Body Reactions ◽  
The 1960S

Biodegradable plates have been used extensively in fracture fixation since the 1960s. They rarely cause stress-protection atrophy or problems requiring secondary plate removal, common complications seen with metallic plates. However, aseptic foreign-body reactions have been reported, sometimes years after the original implantation. Both inadequate polymer degradation and debris accumulation have been implicated as causes. The current generation of commercial biodegradable plates is formulated to minimize this complication by altering the ratio of polylactic and polyglycolic acids. This in vivo study compares the degree of local foreign-body reaction of two commercially available resorbable plates in rabbits. Two types of biodegradable plates were examined: poly(D/L)lactide acid (PDLLA) and polylactide-co-glycolide acid (PLGA). Each plate was placed into a periosteal pericalvarial pocket created beneath the anterior or posterior scalp of a rabbit. Humane killing occurred at 3, 6, and 12 months postoperatively. Foreign-body reaction was evaluated histologically. The PDLLA plates demonstrated marked local foreign-body reactions within the implant capsule as early as 3 months after implantation, with presence of inflammatory cells and granulomatous giant cells in close association with the implant material. All local foreign-body reactions were subclinical with no corresponding tissue swelling requiring drainage. PLGA plates did not demonstrate any signs of inflammatory reactions. In addition, the PLGA plates did not appear to resorb or integrate at 12 months. Neither PDLLA nor PLGA plates demonstrated inflammation of the soft tissue or adjacent bone outside the implant capsule. In our study, the PDLLA plates demonstrated histological evidence of foreign-body reaction that is confined within the implant capsule, which was not seen with the PLGA plates. This finding may be attributable to the lack of significant resorption seen in the PLGA plates. Both PDLLA and PLGA plates were biocompatible with the rabbit tissue environment and should be considered for continued use in craniofacial, maxillofacial, and orthopedic reconstruction.

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