Primary small cell carcinoma of lacrimal sac: case report and literature review

2010 ◽  
Vol 124 (11) ◽  
pp. 1223-1226 ◽  
Author(s):  
T Goto ◽  
N Bandoh ◽  
T Nagato ◽  
M Takahara ◽  
Y Harabuchi ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neck Region ◽  
Japanese Woman ◽  
Small Cell ◽  
Lacrimal Sac ◽  
Old Japanese ◽  
History Of ◽  
Histopathological Studies

AbstractObjective:We present the first reported case of primary small cell carcinoma of the lacrimal sac.Case report:A 67-year-old Japanese woman was referred to our department with a two-month history of left medial canthal swelling, epiphora and occasional nasal bleeding. Nasal endoscopy revealed a readily bleeding tumour in the left inferior meatus. Computed tomography and magnetic resonance imaging scans demonstrated that the tumour was mainly located in the left lacrimal sac. Histopathological studies of a biopsy specimen revealed small cell carcinoma. The patient was treated with four cycles of chemotherapy consisting of cisplatin and etoposide, in combination with radiotherapy. There was no evidence of recurrence or metastasis for five years.Conclusion:Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and to have a poor prognosis. We report a case of primary small cell carcinoma of the lacrimal sac successfully treated with chemo-radiotherapy.

scholarly journals Primary Small Cell Carcinoma of the Hypopharynx: A Case Report of a Rare Tumor

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ali Bayram ◽  
Ebru Akay ◽  
Sema S. Göksu ◽  
İbrahim Özcan
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Systemic Chemotherapy ◽  
Metastatic Potential ◽  
Pyriform Sinus ◽  
Small Cell ◽  
Rare Tumor ◽  
History Of ◽  
The Right

Introduction. Primary hypopharynx involvement of small cell carcinoma is very rare and very few cases have been reported in the literature. Here, we report a case of primary small cell carcinoma of the hypopharynx in a male patient.Case Report. A 50-year-old man presented with a 6-month history of sore throat and swellings in the right side of the neck. Direct laryngoscopy and biopsy revealed small cell carcinoma of the hypopharynx located in the right pyriform sinus.Discussion. Small cell carcinoma of the hypopharynx has no clear treatment modality due to the rarity of the disease. Systemic chemotherapy and radiotherapy should have priority among the therapy regimens because of the high metastatic potential of the tumor.

scholarly journals Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Yingqiu Song ◽  
Zhenyu Lin ◽  
Lingjuan Chen ◽  
Gang Wu
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Cushing’S Syndrome ◽  
Neck Region ◽  
Cushing's Syndrome ◽  
Small Cell ◽  
First Case ◽  
Tender Mass ◽  
One Year

We report a 24-year-old woman presenting with a relapsed soy-bean-size tender mass at the junction of the soft and hard palate and a history of palatine tumor of small cell carcinoma. Reexcision surgery was performed and histopathological features were consistent. The patient was treated with six cycles of chemotherapy consisting of etoposide and cisplatin. After one year, the patient developed bone metastases and Cushing's syndrome, and successfully recovered with subsequent chemotherapy with irinotecan and cisplatin plus radiotherapy. There was no evidence of recurrence or metastasis for more than three years. Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. This is the first case report of a patient with relapsed primary small cell carcinoma of the palate and successfully treated with second-line chemotherapy and local radiotherapy.

Small Cell Carcinoma Manifesting as a Bulky Thoracic Mass in a Pregnant Woman: A Case Report

2006 ◽  
Vol 55 (5) ◽  
pp. 477
Author(s):  
In Jae Lee ◽  
Kwang Seok Eom ◽  
Seon Young Jeon ◽  
Im Kyung Hwang ◽  
Yul Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell

scholarly journals Metastatic small cell carcinoma of the lung with prominent spindle cell morphology and hemangiopericytoma-like vascular pattern: A sarcoma mimicker

2020 ◽  
Vol 8 ◽  
pp. 2050313X2098117
Author(s):  
Esra Nsour ◽  
Ali Al Khader ◽  
Bushra Al-Tarawneh
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Spindle Cell ◽  
Small Cell ◽  
Nerve Sheath Tumor ◽  
Vascular Pattern ◽  
Nerve Sheath ◽  
History Of ◽  
Wall Mass ◽  
Aggressive Clinical Behavior

Small cell carcinoma is a malignant neuroendocrine tumor with aggressive clinical behavior. Histologically, the tumor is characterized by the proliferation of small, round, blue cells. Here, we present the case of a 50-year-old man with a 1-month history of enlarging chest wall mass. Microscopic examination of the lesion revealed a highly cellular neoplasm composed of closely packed, atypical spindle cells with scant cytoplasm, inconspicuous nucleoli, and brisk mitotic activity. The hemangiopericytoma-like vascular pattern was prominent. Areas showing a fibrosarcoma-like fascicular pattern were also observed. The tumor was immunohistochemically positive for TTF1, synaptophysin, and chromogranin, confirming small cell carcinoma. Further investigations revealed a lung origin and widespread metastases. The tumor in this case closely mimicked synovial sarcoma or malignant peripheral nerve sheath tumor. Small cell carcinoma demonstrates a hemangiopericytoma-like pattern that can mimic sarcoma histologically. This is a serious pitfall that can significantly affect the speed of diagnosis and management.

Small cell carcinoma of endometrium – a case report

Pathology ◽  
2017 ◽  
Vol 49 ◽  
pp. S89
Author(s):  
Sagarika Tripathy ◽  
Anthony Kelmann
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell

Refractory Pleural Small Cell Carcinoma in Never Smoker. A Case Report

2008 ◽  
Vol 94 (3) ◽  
pp. 434-436 ◽  
Author(s):  
Marcello Tiseo ◽  
Elena Spiritelli ◽  
Marzia Capelletti ◽  
Guido Rindi ◽  
Andrea Ardizzoni
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Never Smoker

Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type

2021 ◽  
Vol 14 (7) ◽  
pp. e243571
Author(s):  
Annalisa Montebello ◽  
Mark Gruppetta
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Incidental Finding ◽  
Lower Abdominal Pain ◽  
Ovarian Tumour ◽  
Small Cell ◽  
Pelvic Radiotherapy ◽  
Wide Range ◽  
History Of ◽  
Parathyroid Hormone Related Peptide

A 37-year-old woman presented with a few days’ history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour—ovarian small cell carcinoma of the hypercalcaemic type. Acute treatment of hypercalcaemia consisted of aggressive intravenous fluids and bisphosphonates. She underwent surgery to remove the tumour and is currently receiving systemic platinum/etoposide chemotherapy combination to be followed by pelvic radiotherapy. This case highlights the wide range of differential diagnosis for hypercalcaemia and the importance of a stepwise and thorough approach during investigations. We discuss the pathophysiology of malignancy-related hypercalcaemia, focusing especially on parathyroid hormone-related peptide-associated hypercalcaemia.

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