Efficacy of low-dose intratympanic dexamethasone as a salvage treatment for idiopathic sudden sensorineural hearing loss: the Modbury Hospital experience

2014 ◽  
Vol 128 (S2) ◽  
pp. S27-S30 ◽  
Author(s):  
S Oue ◽  
J Jervis-Bardy ◽  
L Stepan ◽  
S Chong ◽  
C-K L Shaw
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Low Dose ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
Dexamethasone Therapy ◽  
Oral Steroid Therapy ◽  
Intratympanic Dexamethasone

AbstractObjective:To evaluate the efficacy of low-dose intratympanic dexamethasone therapy in patients with idiopathic sudden sensorineural hearing loss whose hearing in the affected ear had failed to improve following a course of oral steroid therapy.Methods:A prospective pilot study was undertaken of eight patients with idiopathic sudden sensorineural hearing loss whose hearing had failed to improve after a course of prednisolone. These patients subsequently received 8 mg intratympanic dexamethasone therapy, delivered via a ventilation tube on a weekly basis for 1 month. Clinical outcome was assessed weekly with pure tone audiography.Results:At the end of the 1-month treatment period, no significant hearing improvement was observed on pure tone audiography in any of the patients (i.e. improvements were all less than 10 dB).Conclusion:The response to 8 mg of intratympanic dexamethasone used as a salvage therapy for idiopathic sudden sensorineural hearing loss was inadequate. A higher dosage of intratympanic dexamethasone might be required to achieve better outcomes.

scholarly journals Effect of Intratympanic Dexamethasone in Idiopathic Sudden Sensorineural Hearing Loss

2019 ◽  
Vol 27 (2) ◽  
pp. 135-139
Author(s):  
Rabi Hembrom ◽  
Indranil Sen ◽  
Bina Tamang ◽  
Satadal Mandal ◽  
Amit Chakrabarti
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
Hearing Improvement ◽  
Oral Steroids ◽  
Oral Steroid Therapy ◽  
A Prospective Study ◽  
Intratympanic Dexamethasone

Introduction Oral steroids currently represent the standard treatment for idiopathic sudden sensorineural hearing loss The aim of this study is to assess the effectiveness of intratympanic dexamethasone injection for treating ‘Idiopathic sudden sensori-neural hearing loss’ (ISSNHL) not improved with conventional oral steroid. Materials and Methods A prospective study was conducted on 30 patients refractory to oral steroid therapy between June 2017 to May 2018. ‘Intratympanic dexamethasone injection’ (ITDI) was given every week for 3 consecutive weeks. Hearing was assessed by performing pure tone audiogram before every ITDI and also 1 week after the completion of treatment. Results Hearing improvement was found in 19 out of the 30 cases (63.3%).   Conclusions Intratympanic dexamethasone significantly improves the prognosis of ISSNHL and is a safe, inexpensive and effective treatment.

scholarly journals Effect of intratympanic dexamethasone injection in sudden idiopathic sensorineural hearing loss

2016 ◽  
Vol 2 (4) ◽  
pp. 258
Author(s):  
K. Mallikarjuna Swamy ◽  
Arati Ganiger
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Hearing Improvement ◽  
Pure Tone Audiogram ◽  
Intravenous Steroid ◽  
A Prospective Study ◽  
Intratympanic Dexamethasone

<p class="abstract"><strong>Background:</strong> The aim of this study is to assess the effect of intratympanic dexamethasone injection (ITDI) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).</p><p><strong>Methods:</strong> A prospective study was conducted on 40 patients refractory to intravenous steroid therapy between May 2012 to March 2014. Intratympanic dexamethasone injection was given every week for 3 consecutive weeks. Hearing was assessed by performing pure tone audiogram before every ITDI and also 1 week after the completion of treatment.</p><p><strong>Results: </strong>Hearing improvement was seen in 27 out of the 40 cases (68%).<strong></strong></p><p class="abstract"><strong>Conclusions:</strong> Intratympanic dexamethasone significantly improves the prognosis of ISSNHL and is a safe, inexpensive and effective treatment in ISSNHL.</p>

scholarly journals Intratympanic steroids versus oral steroids in idiopathic sudden sensorineural hearing loss, hospital-based study

2020 ◽  
Vol 6 (9) ◽  
pp. 1663
Author(s):  
Arshed Alil ◽  
Omar Mohammad Shafi ◽  
Farah Deeba
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Pure Tone ◽  
Oral Prednisolone ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
Injection Group ◽  
Steroid Group ◽  
Oral Steroids

<p class="abstract"><strong>Introduction: </strong>Idiopathic Sudden sensorineural hearing loss (ISSHL) is defined as a hearing loss of 30 dB or more, affecting at least 3 consecutive frequencies, occurring within 3 days without any identifiable cause. To find the effectiveness of intratympanic steroid injection (ITS) for hearing recovery and comparing the results with oral steroids therapy. </p><p class="abstract"><strong>Materials and Methods: </strong>This prospective study was done in the department of ENT, Govt medical college, Srinagar, over a period of two years. A total 60 patients of ISSHL was selected for the study. Through examination, otoscopy and pure tone audiometry (PTA) was done for all the cases before initiation of therapy. Thirty patients received and thirty patients received oral prednisolone for a protocol-based dose and duration. PTA was repeated every two weeks over duration of two months for documentation of improvement of hearing on pure tone four frequency averages.</p><p class="abstract"><strong>Results:</strong> Chances of recovery were more with middle ear injection group in 18 patients (60%) in comparison to oral steroids in 14 patients (46.66%). Complete recovery was found in six cases (20%) in injection group and four cases (13.33%) in oral steroid group. The ITS group showed a better control of associated symptoms like dizziness, tinnitus and vertigo are controlled better with ITS (73.33%) than oral steroid group (56.66%). The ITS group showed faster recovery also with lower side effects.</p><p class="abstract"><strong>Conclusion: </strong>Intratympanic dexamethasone injection is more effective in comparison to oral prednisolone for the management of ISSHL, however larger studies may be required.</p>

Metronidazole ototoxicity - report of two cases

1999 ◽  
Vol 113 (4) ◽  
pp. 355-357 ◽  
Author(s):  
S. M. Iqbal ◽  
J. G. Murthy ◽  
P. K. Banerjee ◽  
K. A. Vishwanathan
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Oral Administration ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
World Literature ◽  
Sensorineural Hearing ◽  
Oral Steroid ◽  
The World ◽  
Oral Steroid Therapy

AbstractTwo cases of bilateral moderate to severe sensorineural hearing loss due to oral administration of metronidazole are reported. There has been only one case report of deafness following metronidazole therapy in the world literature. The hearing loss recovered gradually in a period of four to six weeks following withdrawal of drug and oral steroid therapy. The possible mechanism of ototoxicity is discussed. Awareness by the treating physician of ototoxicity due to any drug is stressed.

Sign in / Sign up

Export Citation Format

Share Document