The host-parasite relationship of Schistosoma japonicum in CBA mice

Parasitology ◽  
1983 ◽  
Vol 87 (2) ◽  
pp. 327-342 ◽  
Author(s):  
N. A. Moloney ◽  
G. Webbe
Keyword(s):  
Schistosoma Japonicum ◽  
Egg Laying ◽  
Portal System ◽  
Cba Mice ◽  
Egg Deposition ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
The Mean ◽  
Host Parasite ◽  
Relationship Of

SUMMARYThe host–parasite relationship of the Chinese mainland strain of Schistosoma japonicum in CBA mice is described and compared to previous reports on this parasite in mice. S. japonicum took under 2 weeks to complete its migration to the portal system of mice, and peak passage of schistosomula through the lungs occurred 5–6 days after infection. The mean percentage establishment of worms, which was independent of the infecting inoculum, was 46%. The adult worm burdens remained constant over a 28-week period of infection. Male and female worms reached maximum mean lengths of 13 and 19 mm, respectively. Egg laying commenced 30 days after infection. The number of ova deposited in the liver stabilized at some 55000 by 12 weeks of infection with 30 cercariae, but the intestinal egg burden rose from 132000 at 12 weeks to 430000 at 28 weeks. Faecal eggs were first observed 6 weeks after mice were exposed to 100 cercariae and 7 weeks after lighter exposures. Faecal egg output also stabilized 12 weeks after infection. The formation of granulomas in the liver occurred within 2 weeks of egg deposition and encompassed a maximum area 14 weeks after infection. Fifty per cent mortality occurred 15 weeks after exposure, but only in hosts infected with 100 cercariae.

The host—parasite relationship ofSchistosoma haematobiumin CBA mice

Parasitology ◽  
1988 ◽  
Vol 97 (3) ◽  
pp. 403-424 ◽  
Author(s):  
A. M. Agnew ◽  
S. B. Lucas ◽  
M. J. Doenhoff
Keyword(s):  
Post Infection ◽  
Schistosoma Haematobium ◽  
Egg Laying ◽  
Male And Female ◽  
Cba Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Hepatic Granulomas ◽  
The Mean ◽  
Host Parasite

SummaryThe host—parasite relationships of two geographical isolates ofSchistosoma haematobiumin CBA mice are described and compared to previous reports on this parasite in other experimental hosts and in man. The mean percentage establishment of worms in mice was 17% and was not affected by the age or sex of the host. Adult worm burdens remained constant over 20 weeks, but were reduced after 18 months of infection. Male and female worms reached mean maximum lengths of 4·78 and 5·9 mm respectively. Egg laying commenced 9·5 weeks after infection and eggs accumulated in the tissues throughout the period of infection. A large increase in the rate of egg accumulation occurred coincidental with the appearance of eggs in the bladder of some mice. Faecal eggs were first observed in some mice at 12·5 weeks and most mice excreted a few eggs by 17 weeks p.i. (post-infection). Eggs were not found in the urine of infected mice. Excreted eggs and eggs isolated from the livers of infected mice hatched, but the resulting miracidia were unable to infect appropriate snail hosts. The development of hepatic granulomas and egg-induced pathology in the bladder of mice is described.

Longevity ofEchinostoma caproniin Balb/c mice

2008 ◽  
Vol 82 (1) ◽  
pp. 95-96 ◽  
Author(s):  
B. Fried ◽  
R.C. Peoples
Keyword(s):  
The Other ◽  
Term Survival ◽  
Long Term Survival ◽  
Echinostoma Caproni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
The Mean ◽  
Host Parasite ◽  
Relationship Of

AbstractThis study used Balb/c mice to examine the longevity ofEchinostoma caproni. Five mice each exposed to 75 encysted metacercariae (cysts) were necropsied at 23 weeks postinfection (PI) (160 days PI). Two of the 5 were infected with a total of 33 worms; 23 in one mouse and 10 in the other. Body and organ area measurements showed that these worms were robust and normal in appearance. No signs of atrophy of any of the genital structures were observed. The mean ± SE of eggs/uterus per worm (n = 10) was 243 ± 6. This strain of mouse will be suitable to study the effect of long-term survival on the host–parasite relationship ofE. caproniin Balb/c mice.

Effects of a 100 metacercarial cyst inoculum on the host–parasite relationship of Echinostoma caproni and ICR mice

2001 ◽  
Vol 75 (4) ◽  
pp. 321-324 ◽  
Author(s):  
C.D. Balfour ◽  
M. Rossi ◽  
B. Fried
Keyword(s):  
Body Weight ◽  
High Dose ◽  
Echinostoma Caproni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Host Parasite ◽  
Relationship Of

The host–parasite relationship of a 100 metacercarial cyst inoculum of Echinostoma caproni in the ICR mouse was examined. Three groups of mice, A, B and C, each with six mice per group were used and all mice were necropsied at 14 days postinfection (p.i.), at which time the worms were ovigerous. Group A consisted of uninfected controls, whereas group B received 25 cysts per mouse (low dose) and group C received 100 cysts per mouse (high dose). There was no significant difference in food consumption between any of the groups from 0 to 14 days p.i. Control mice increased their body weight by 12%, group B by 5%, and group C showed a less than 1% increase in body weight between 0 and 14 days p.i. Echinostome parasitism caused a significant increase in the diameter of the mouse gut, with the gut of group C being more significantly dilated than that of either group A or B. The average worm recovery from group B was 20 worms per host, compared to 72 worms per host from group C. The mean wet and dry weights per worm from group B were 2.4 and 0.4 mg, respectively as compared to 0.6 and 0.2 mg respectively for group C. The mean number of uterine eggs per worm from group B was 180 compared to 125 for worms from group C. Worms from group C were more widely distributed in the small intestine than those from group B. Crowding effects associated with the high dose infection were clearly demonstrated in E. caproni from ICR mice.

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections

Parasitology ◽  
1961 ◽  
Vol 51 (1-2) ◽  
pp. 173-179 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Relative Length ◽  
Industrial Research ◽  
Male Mice ◽  
Male And Female ◽  
Female Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Host Parasite ◽  
Relationship Of

1. It has been shown that there is a difference between the resistance of male and female mice to infection with Nematospiroides dubius.2. More parasites were harboured, during both the larval and adult parasitic phases, by male mice.3. These worms were found to occupy a similar relative length of the intestine between the stomach and the caecum in male and female mice infected for either 5 or 10 days.4. The relative length of the intestine infected on the fifth day was significantly greater than that infected on the tenth day.This investigation was carried out during the tenure of a Research Studentship from the Department of Scientific and Industrial Research. I should like to thank Professor I. Chester Jones, in whose department the work was done, for the facilities provided and Dr E. T. B. Francis for his helpful and critical supervision.

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