The host—parasite relationship ofSchistosoma haematobiumin CBA mice

Parasitology ◽  
1988 ◽  
Vol 97 (3) ◽  
pp. 403-424 ◽  
Author(s):  
A. M. Agnew ◽  
S. B. Lucas ◽  
M. J. Doenhoff
Keyword(s):  
Post Infection ◽  
Schistosoma Haematobium ◽  
Egg Laying ◽  
Male And Female ◽  
Cba Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Hepatic Granulomas ◽  
The Mean ◽  
Host Parasite

SummaryThe host—parasite relationships of two geographical isolates ofSchistosoma haematobiumin CBA mice are described and compared to previous reports on this parasite in other experimental hosts and in man. The mean percentage establishment of worms in mice was 17% and was not affected by the age or sex of the host. Adult worm burdens remained constant over 20 weeks, but were reduced after 18 months of infection. Male and female worms reached mean maximum lengths of 4·78 and 5·9 mm respectively. Egg laying commenced 9·5 weeks after infection and eggs accumulated in the tissues throughout the period of infection. A large increase in the rate of egg accumulation occurred coincidental with the appearance of eggs in the bladder of some mice. Faecal eggs were first observed in some mice at 12·5 weeks and most mice excreted a few eggs by 17 weeks p.i. (post-infection). Eggs were not found in the urine of infected mice. Excreted eggs and eggs isolated from the livers of infected mice hatched, but the resulting miracidia were unable to infect appropriate snail hosts. The development of hepatic granulomas and egg-induced pathology in the bladder of mice is described.

The host-parasite relationship of Schistosoma japonicum in CBA mice

Parasitology ◽  
1983 ◽  
Vol 87 (2) ◽  
pp. 327-342 ◽  
Author(s):  
N. A. Moloney ◽  
G. Webbe
Keyword(s):  
Schistosoma Japonicum ◽  
Egg Laying ◽  
Portal System ◽  
Cba Mice ◽  
Egg Deposition ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
The Mean ◽  
Host Parasite ◽  
Relationship Of

SUMMARYThe host–parasite relationship of the Chinese mainland strain of Schistosoma japonicum in CBA mice is described and compared to previous reports on this parasite in mice. S. japonicum took under 2 weeks to complete its migration to the portal system of mice, and peak passage of schistosomula through the lungs occurred 5–6 days after infection. The mean percentage establishment of worms, which was independent of the infecting inoculum, was 46%. The adult worm burdens remained constant over a 28-week period of infection. Male and female worms reached maximum mean lengths of 13 and 19 mm, respectively. Egg laying commenced 30 days after infection. The number of ova deposited in the liver stabilized at some 55000 by 12 weeks of infection with 30 cercariae, but the intestinal egg burden rose from 132000 at 12 weeks to 430000 at 28 weeks. Faecal eggs were first observed 6 weeks after mice were exposed to 100 cercariae and 7 weeks after lighter exposures. Faecal egg output also stabilized 12 weeks after infection. The formation of granulomas in the liver occurred within 2 weeks of egg deposition and encompassed a maximum area 14 weeks after infection. Fifty per cent mortality occurred 15 weeks after exposure, but only in hosts infected with 100 cercariae.

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections

Parasitology ◽  
1961 ◽  
Vol 51 (1-2) ◽  
pp. 173-179 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Relative Length ◽  
Industrial Research ◽  
Male Mice ◽  
Male And Female ◽  
Female Mice ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Host Parasite ◽  
Relationship Of

1. It has been shown that there is a difference between the resistance of male and female mice to infection with Nematospiroides dubius.2. More parasites were harboured, during both the larval and adult parasitic phases, by male mice.3. These worms were found to occupy a similar relative length of the intestine between the stomach and the caecum in male and female mice infected for either 5 or 10 days.4. The relative length of the intestine infected on the fifth day was significantly greater than that infected on the tenth day.This investigation was carried out during the tenure of a Research Studentship from the Department of Scientific and Industrial Research. I should like to thank Professor I. Chester Jones, in whose department the work was done, for the facilities provided and Dr E. T. B. Francis for his helpful and critical supervision.

The effect of cyclosporin A on the course ofParagonimus miyazakiiinfection in rats

1988 ◽  
Vol 62 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Yoshihisa Hashiguchi ◽  
Yoshisuke Okamura
Keyword(s):  
Cyclosporin A ◽  
Post Infection ◽  
Recovery Rate ◽  
Cyst Formation ◽  
Fungal Metabolite ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Host Parasite ◽  
Time Of Administration ◽  
Lower Recovery

ABSTRACTThe effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course ofParagonimus miyazakiiinfection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA − 1 to + 3 days post-infection enhanced the growth and maturation ofP. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.

Longevity ofEchinostoma caproniin Balb/c mice

2008 ◽  
Vol 82 (1) ◽  
pp. 95-96 ◽  
Author(s):  
B. Fried ◽  
R.C. Peoples
Keyword(s):  
The Other ◽  
Term Survival ◽  
Long Term Survival ◽  
Echinostoma Caproni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
The Mean ◽  
Host Parasite ◽  
Relationship Of

AbstractThis study used Balb/c mice to examine the longevity ofEchinostoma caproni. Five mice each exposed to 75 encysted metacercariae (cysts) were necropsied at 23 weeks postinfection (PI) (160 days PI). Two of the 5 were infected with a total of 33 worms; 23 in one mouse and 10 in the other. Body and organ area measurements showed that these worms were robust and normal in appearance. No signs of atrophy of any of the genital structures were observed. The mean ± SE of eggs/uterus per worm (n = 10) was 243 ± 6. This strain of mouse will be suitable to study the effect of long-term survival on the host–parasite relationship ofE. caproniin Balb/c mice.

scholarly journals Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Parasitology ◽  
1989 ◽  
Vol 98 (2) ◽  
pp. 283-289 ◽  
Author(s):  
P. Garside ◽  
J. M. Behnke
Keyword(s):  
Post Infection ◽  
Primary Infection ◽  
Normal Values ◽  
Adult Stage ◽  
Hookworm Infection ◽  
Ancylostoma Ceylanicum ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Canine Models ◽  
Host Parasite

SUMMARYThe course of primary infection with a hamster-adapted strain of Ancylostoma ceylanicum was studied in inbred DSN and randomly bred WO/GD and WO/CR hamsters. Infective larvae were administered orally and began to develop in the small intestine without embarking on a tissue migration. Only the occasional larva was detected in other organ sites. It was concluded that the developing larvae moulted on days 3–4 and again to the pre-adult stage about 9–11 days post-infection. Worm burdens in infected hamsters were stable for at least 11 weeks after infection. There was no sudden expulsive phase and some adult worms survived for over 200 days. Overall the sex ratio of worms in groups of hamsters killed concurrently was about 50% although occasionally the ratio was biased in favour of one sex in individual animals. The blood packed cell volume (PCV) was significantly depressed 2 weeks following infection and continued to decline until a point of stability was achieved 4–5 weeks post-infection. The PCV subsequently remained depressed throughout the period of observation. Infected hamsters lost weight if kept in groups, but not when housed in separate cages. Groups of animals which lost weight did not recover to normal values within 11 weeks of infection. It is suggested that this model of hookworm infection has scope for exploring aspects of the host-parasite relationship which the canine models cannot fulfill adequately.

Effects of a 100 metacercarial cyst inoculum on the host–parasite relationship of Echinostoma caproni and ICR mice

2001 ◽  
Vol 75 (4) ◽  
pp. 321-324 ◽  
Author(s):  
C.D. Balfour ◽  
M. Rossi ◽  
B. Fried
Keyword(s):  
Body Weight ◽  
High Dose ◽  
Echinostoma Caproni ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Host Parasite ◽  
Relationship Of

The host–parasite relationship of a 100 metacercarial cyst inoculum of Echinostoma caproni in the ICR mouse was examined. Three groups of mice, A, B and C, each with six mice per group were used and all mice were necropsied at 14 days postinfection (p.i.), at which time the worms were ovigerous. Group A consisted of uninfected controls, whereas group B received 25 cysts per mouse (low dose) and group C received 100 cysts per mouse (high dose). There was no significant difference in food consumption between any of the groups from 0 to 14 days p.i. Control mice increased their body weight by 12%, group B by 5%, and group C showed a less than 1% increase in body weight between 0 and 14 days p.i. Echinostome parasitism caused a significant increase in the diameter of the mouse gut, with the gut of group C being more significantly dilated than that of either group A or B. The average worm recovery from group B was 20 worms per host, compared to 72 worms per host from group C. The mean wet and dry weights per worm from group B were 2.4 and 0.4 mg, respectively as compared to 0.6 and 0.2 mg respectively for group C. The mean number of uterine eggs per worm from group B was 180 compared to 125 for worms from group C. Worms from group C were more widely distributed in the small intestine than those from group B. Crowding effects associated with the high dose infection were clearly demonstrated in E. caproni from ICR mice.

The mouse as a suitable host for an isolate of Schistosoma haematobium from Niger

1992 ◽  
Vol 66 (1) ◽  
pp. 1-6 ◽  
Author(s):  
D. Imbert-Establet ◽  
C. Vera ◽  
B. Sellin ◽  
J. Jourdane
Keyword(s):  
Sex Ratio ◽  
Post Infection ◽  
Schistosoma Haematobium ◽  
White Mouse ◽  
First Passage ◽  
Suitable Host ◽  
Genetic Characteristics ◽  
Bulinus Truncatus ◽  
The Mean ◽  
Host Parasite

ABSTRACTThe host-parasite relationships of a Schistosoma haematobium isolate, originating from Niger, and the white mouse are described. Swiss OF1 albino mice were exposed individually to 200 cercariae and worms were recovered 9, 12, 16 and 20 weeks post infection. The mean worm returns ranged between 10·54 and 13·5% and did not alter significantly between 9 and 20 weeks post infection. The sex ratio of worms was always in favour of males; from 7·9:1 at 9 weeks after infection it decreased regularly to 3·28:1 at 20 weeks. Male worms reached a mean length of 8·72 mm at 20 weeks. From the 12th week post infection, a high number of eggs was found in the liver and gut. At 20 weeks, eggs were also found in the bladder. Viable eggs and infective miracidia were obtained. The infection of Bulinus truncatus from Niger succeeded with a mean rate of 61% after the first passage through mice. The isolate of S. haematobium was maintained in the laboratory during 3 successive passages through mice. These entirely new results are very probably linked to genetic characteristics peculiar to the S. haematobium populations from Niger.

Host-parasite relationships in flatfish (Pleuronectiformes) – the relative importance of host biology, ecology and phylogeny

Parasitology ◽  
2010 ◽  
Vol 138 (1) ◽  
pp. 107-121 ◽  
Author(s):  
J. F. MARQUES ◽  
M. J. SANTOS ◽  
C. M. TEIXEIRA ◽  
M. I. BATISTA ◽  
H. N. CABRAL
Keyword(s):  
Maximum Size ◽  
Taxonomic Distinctness ◽  
Relative Importance ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
The Mean ◽  
Abundance And Diversity ◽  
Host Parasite ◽  
Different Sources ◽  
Host Characteristics

SUMMARYThe extent to which host biology, ecology and phylogeny determine the diversity of macroparasite assemblages has been investigated in recent years in several taxa, including fish. However, consensus has not been reached probably as a result of data being collected from different sources, different temporal scales or host and parasite biogeography and phylogeny having greater influence than expected. The present study evaluates the relative importance of 27 biological, ecological and phylogenetic characteristics of 14 flatfish species on the diversity of their ecto- and endoparasite assemblages, comprising a total of 53 taxa. Redundancy analyses were applied to the mean abundance of each parasite taxa infecting each host and to the richness, taxonomic distinctness and variance in taxonomic distinctness calculated for each assemblage within each host. Only a few host characteristics contributed significantly to the observed patterns: host distribution was more important in determining the type and mean abundance of ectoparasites present in an assemblage, whereas diversity of these assemblages were mainly related to the host's maximum size. Endoparasite mean abundance and diversity were mostly influenced by the number of food items ingested and by the presence of Crustacea and Polychaeta in the diet. However, the sympatric occurrence of related hosts also played an important role in the diversity values found in macroparasite assemblages. Results showed that a host characteristic has different importance according to the host-parasite relationship being examined, suggesting an important role for host-parasite co-evolution on the diversity of extant macroparasite assemblages.

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis): IV. The effect of the host's age on experimental infections in the mouse and rat

Parasitology ◽  
1962 ◽  
Vol 52 (1-2) ◽  
pp. 31-40 ◽  
Author(s):  
Colin Dobson
Keyword(s):  
Female Mouse ◽  
Male Rat ◽  
Female Rat ◽  
Male And Female ◽  
Experimental Infections ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Nematospiroides Dubius ◽  
Host Parasite ◽  
Relationship Of

1. The mouse and rat (an abnormal host) show an age resistance towards experimental infections with N. dubius.2. This resistance was complicated by a different reaction in the male and female mouse and rat.3. The rat exhibits age resistance despite being gonadectomized immediately after weaning.4. Gonadectomy with replacement of the homologous sex hormone did not materially alter the age resistance of the host, but the administration of testosterone to the castrated male rat increased the numbers of larvae which penetrated the gut wall. Oestradiol decreased these numbers in the spayed female rat.5. The relationships between the age resistance and the sex resistance of the hosts was discussed.

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