Testing the flow-through capillary for the study of re-solvation processes in pharmaceutical compounds

2020 ◽  
Vol 35 (3) ◽  
pp. 160-165
Author(s):  
Jan Rohlíček ◽  
Vít Zvoníček ◽  
Eliška Skořepová ◽  
Miroslav Šoóš
Keyword(s):  
Pharmaceutical Compounds ◽  
Sample Holder ◽  
Practical Application ◽  
Capillary Sample ◽  
Flow Through ◽  
Solvation Processes

This paper describes a new flow-through capillary sample holder that allows the in situ study of re-solvation processes. The holder can be aligned to the goniometer's center using two perpendicular micrometric tables that move in y and z directions. The re-solvation of two ibrutinib solvates of anisole and fluorobenzene was tested using the holder to show the practical application of this technique.

Functional response of Fucus vesiculosus communities to tributyltin measured in an in situ continuous flow-through system

Hydrobiologia ◽  
1989 ◽  
Vol 188-189 (1) ◽  
pp. 277-283 ◽  
Author(s):  
C. Lindblad ◽  
U. Kautsky ◽  
C. André ◽  
N. Kautsky ◽  
M. Tedengren
Keyword(s):  
Functional Response ◽  
Continuous Flow ◽  
Fucus Vesiculosus ◽  
Flow Through

Simple flow through reaction cells for in situ transmission and fluorescence x-ray-absorption spectroscopy of heterogeneous catalysts

2006 ◽  
Vol 77 (2) ◽  
pp. 023105 ◽  
Author(s):  
Simon R. Bare ◽  
George E. Mickelson ◽  
Frank S. Modica ◽  
Andrzej Z. Ringwelski ◽  
N. Yang
Keyword(s):  
Absorption Spectroscopy ◽  
Heterogeneous Catalysts ◽  
X Ray ◽  
Flow Through ◽  
X Ray Absorption ◽  
Simple Flow

In situ determination of porewater gases by underwater flow-through membrane inlet mass spectrometry

2012 ◽  
Vol 10 (3) ◽  
pp. 117-128 ◽  
Author(s):  
Ryan J. Bell ◽  
William B. Savidge ◽  
Strawn K. Toler ◽  
Robert H. Byrne ◽  
R. Timothy Short
Keyword(s):  
Mass Spectrometry ◽  
Membrane Inlet Mass Spectrometry ◽  
Flow Through

In Situ Enhancement of Flow-through Porous Electrodes with Carbon Nanotubes via Flowing Deposition

2016 ◽  
Vol 206 ◽  
pp. 36-44 ◽  
Author(s):  
Marc-Antoni Goulet ◽  
Aronne Habisch ◽  
Erik Kjeang
Keyword(s):  
Carbon Nanotubes ◽  
Porous Electrodes ◽  
Flow Through

scholarly journals Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

2020 ◽  
Author(s):  
Anna Davies ◽  
keegan fitzpatrick ◽  
Rick Betori ◽  
Karl Scheidt
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Pharmaceutical Compounds ◽  
Single Electron ◽  
Photoredox Catalysis ◽  
Radical Coupling ◽  
Electron Reduction

Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium <i>in situ</i> followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.

scholarly journals An instrumented sample holder for time-lapse microtomography measurements of snow under advective airflow

2014 ◽  
Vol 3 (2) ◽  
pp. 179-185 ◽  
Author(s):  
P. P. Ebner ◽  
S. A. Grimm ◽  
M. Schneebeli ◽  
A. Steinfeld
Keyword(s):  
Structural Changes ◽  
Time Lapse ◽  
Temperature Gradients ◽  
Sample Holder ◽  
Experimental Characterization ◽  
Computational Fluid Dynamics Simulations ◽  
Dynamics Simulations ◽  
Snow Samples

Abstract. An instrumented sample holder was developed for time-lapse microtomography of snow samples to enable in situ nondestructive spatial and temporal measurements under controlled advective airflows, temperature gradients, and air humidities. The design was aided by computational fluid dynamics simulations to evaluate the airflow uniformity across the snow sample. Morphological and mass transport properties were evaluated during a 4-day test run. This instrument allows the experimental characterization of metamorphism of snow undergoing structural changes with time.

In-situ coating of lithiophilic interphase on a biporous Cu scaffold with vertical microchannels for dendrite-free Li metal batteries

2021 ◽  
Author(s):  
Li-Min Wang ◽  
Xiaokuan Ban ◽  
Zongzi Jin ◽  
Ranran Peng ◽  
Chusheng Chen ◽  
...  
Keyword(s):  
Volume Change ◽  
Coulombic Efficiency ◽  
Dendrite Growth ◽  
Porous Scaffolds ◽  
Effective Strategy ◽  
Practical Application ◽  
Metal Anode ◽  
Li Metal Anode ◽  
In Situ Coating

Severe dendrite growth, low Coulombic efficiency and huge volume change have impeded the practical application of Li metal anode, and the construction of porous scaffolds is an effective strategy to...

Blood flow elevation increases VO2 maximum during repetitive tetanic contractions of dog muscle in situ

1993 ◽  
Vol 74 (4) ◽  
pp. 1499-1503 ◽  
Author(s):  
W. F. Brechue ◽  
B. T. Ameredes ◽  
G. M. Andrew ◽  
W. N. Stainsby
Keyword(s):  
Blood Flow ◽  
Perfusion Pressure ◽  
Power Production ◽  
Arterial Supply ◽  
O2 Uptake ◽  
Plantaris Muscle ◽  
Control Series ◽  
Flow Through ◽  
Series Of Experiments

Blood flow through the gastrocnemius-plantaris muscle of the dog in situ was increased by a pump in the arterial supply during a 30-min period of 1/s isotonic tetanic contractions. Compared with a control series of experiments with normoxemia and spontaneous flow, the pump increased flow 84%, from 1.51 +/- 0.08 to 2.78 +/- 0.15 ml.g-1.min-1. The perfusion pressure was increased from 125 to 196 mmHg. The pump hyperemia increased maximal O2 uptake (VO2) at 5 min of contractions by 31%, from 8.97 +/- 0.44 to 12.89 +/- 0.30 mumol.g-1.min-1. The extraction was decreased, and venous PO2 (PVO2) was increased. Fatigue, measured as a drop in power production from the highest level at 10 s to 30 min, was 49% during pump hyperemia and 54% in the control conditions. VO2 decreased 30% from the 5-min value to the 30-min value with pump hyperemia and 28% over the same time in the control conditions. At maximal VO2, the ratio VO2/PVO2 was increased by pump hyperemia compared with control conditions, suggesting an increased O2 diffusing conductance of the muscles. We conclude that the elevated perfusion pressure of pump hyperemia increased flow to raise maximal VO2 mainly in areas of the muscle that had restricted flow under control conditions.

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