scholarly journals Diarrhoea, enteric pathogen detection and nutritional indicators among controls in the Global Enteric Multicenter Study, Kenya site: an opportunity to understand reference populations in case–control studies of diarrhoea

2018 ◽  
Vol 147 ◽  
Author(s):  
D. M. Berendes ◽  
C. E. O'Reilly ◽  
S. Kim ◽  
R. Omore ◽  
J. B. Ochieng ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Pathogen Detection ◽  
Reference Population ◽  
Case Control ◽  
Enteric Pathogen ◽  
Case Control Studies ◽  
Long Term Outcomes ◽  
Enteric Infections

AbstractGiven the challenges in accurately identifying unexposed controls in case–control studies of diarrhoea, we examined diarrhoea incidence, subclinical enteric infections and growth stunting within a reference population in the Global Enteric Multicenter Study, Kenya site. Within ‘control’ children (0–59 months old without diarrhoea in the 7 days before enrolment,n= 2384), we examined surveys at enrolment and 60-day follow-up, stool at enrolment and a 14-day post-enrolment memory aid for diarrhoea incidence. At enrolment, 19% of controls had ⩾1 enteric pathogen associated with moderate-to-severe diarrhoea (‘MSD pathogens’) in stool; following enrolment, many reported diarrhoea (27% in 7 days, 39% in 14 days). Controls with and without reported diarrhoea had similar carriage of MSD pathogens at enrolment; however, controls reporting diarrhoea were more likely to report visiting a health facility for diarrhoea (27%vs.7%) or fever (23%vs.16%) at follow-up than controls without diarrhoea. Odds of stunting differed by both MSD and ‘any’ (including non-MSD pathogens) enteric pathogen carriage, but not diarrhoea, suggesting control classification may warrant modification when assessing long-term outcomes. High diarrhoea incidence following enrolment and prevalent carriage of enteric pathogens have implications for sequelae associated with subclinical enteric infections and for design and interpretation of case–control studies examining diarrhoea.

scholarly journals Tu1195 LONG-TERM OUTCOMES OF PER-ORAL ENODOSCOPIC MYOTOMY IN ACHALASIA PATIENTS WITH A MINIMUM FOLLOW-UP OF 4 YEARS: A MULTICENTER STUDY

2018 ◽  
Vol 87 (6) ◽  
pp. AB564-AB565
Author(s):  
Olaya I. Brewer Gutierrez ◽  
Pietro Familiari ◽  
Guido Costamagna ◽  
Stefan Seewald ◽  
Shivangi Dorwat ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Long Term Outcomes ◽  
Per Oral

scholarly journals How to study cancers with a possible intrauterine etiology

2006 ◽  
Vol 155 (suppl_1) ◽  
pp. S59-S64
Author(s):  
Jorn Olsen
Keyword(s):  
Cohort Studies ◽  
Case Control ◽  
Case Control Studies ◽  
Ethical Concerns ◽  
Funding Agencies ◽  
Follow Up Studies ◽  
Long Term Follow Up ◽  
Using Data

The concept that many chronic diseases has an early, even fatal, etiology has inspired funding agencies to support large and long-term follow-up studies starting as early in life as possible. These cohort studies provide new opportunities for studying childhood cancer using data that are less biased than those from case-control studies. However, these studies have to be coordinated to reach sufficient sample sizes and a number of novel ethical concerns have to be solved.

scholarly journals New-onset postoperative atrial fibrillation is associated with worse long-term outcome in critically ill patients after non-cardiac surgery: 3-year follow-up of a case-control study

2019 ◽  
Author(s):  
Min Xie ◽  
Shuang-Ling Li ◽  
Jia-Xin Pan ◽  
Sai-Nan Zhu ◽  
Dong-Xin Wang
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Surgery ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Long Term Outcomes ◽  
Control Study ◽  
New Onset

Abstract Background The impact of new-onset postoperative atrial fibrillation (POAF) on long-term outcomes of patients after non-cardiac surgery remains controversial. Here we report the 3-year follow-up of a previous case-control study to determine the relationship between new-onset POAF and long-term outcomes in patients after non-cardiac surgery. Methods In a previous case-control study, 213 patients who were admitted to the intensive care unit (ICU) after non-cardiac surgery were included; of them 71 were in the POAF group and 142 the control group. A telephone interview was performed with patients or their family members at 3 years after surgery. The primary endpoint was the incidence of major adverse cardiovascular events (MACEs) within 3 years, including cardiovascular death, non-fatal cardiac arrest, acute myocardial infarction, congestive heart failure, and ischemic stroke. A logistic regression model was established to assess the association between the occurrence of new-onset POAF and the development of 3-year MACEs. Results 202 patients completed the 3-year follow-up and were included in the analysis; of them 68 were in the POAF group and 134 were in the control group. The incidence of 3-year MACEs was higher in the POAF group than in the control group (64.7% [44/68] vs. 23.1% [31/134], p<0.001). After correction for confounding factors, new-onset POAF was independently associated with an increased risk of 3-year MACEs (odds ratio 5.448, 95% confidence interval 2.202-13.481, p<0.001). Conclusions For adult patients admitted to the ICU after non-cardiac surgery, new-onset POAF was an independent risk factor for the development of MACEs within 3 years.

470 LONG TERM OUTCOMES OF PER-ORAL ENDOSCOPIC MYOTOMY IN ACHALASIA PATIENTS WITH A MINIMUM FOLLOW-UP OF 6 YEARS: A MULTICENTER STUDY

2019 ◽  
Vol 89 (6) ◽  
pp. AB82-AB83
Author(s):  
Jad P. AbiMansour ◽  
Hitomi Minami ◽  
Pietro Familiari ◽  
Rosario Landi ◽  
Guido Costamagna ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Long Term Outcomes ◽  
Per Oral Endoscopic Myotomy ◽  
Endoscopic Myotomy ◽  
Per Oral

Tu2049 Long term Outcomes of PerOral Endoscopic Myotomy (POEM) in Achalasia patients With a minimum follow-up of 2 years: A multicenter study

2016 ◽  
Vol 83 (5) ◽  
pp. AB628 ◽  
Author(s):  
Saowanee Ngamruengphong ◽  
Haruhiro Inoue ◽  
Amol Bapaye ◽  
Michael Ujiki ◽  
Lava Y. Patel ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Peroral Endoscopic Myotomy ◽  
Long Term Outcomes ◽  
Endoscopic Myotomy

Periprocedural risk and long-term outcome of intracranial angioplasty based on a single-centre experience

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 264-274
Author(s):  
Dagmar Krajíčková ◽  
Antonín Krajina ◽  
Miroslav Lojík ◽  
Martina Mulačová ◽  
Martin Vališ
Keyword(s):  
Death Rate ◽  
Long Term Outcomes ◽  
Single Centre ◽  
Intracranial Atherosclerotic Stenosis ◽  
Atherosclerotic Stenosis ◽  
Angioplasty And Stenting ◽  
Aggressive Medical Management ◽  
Stroke Death

Background: Intracranial atherosclerotic stenosis is a major cause of stroke and yet there are currently no proven effective treatments for it. The SAMMPRIS trial, comparing aggressive medical management alone with aggressive medical management combined with intracranial angioplasty and stenting, was prematurely halted when an unexpectedly high rate of periprocedural events was found in the endovascular arm. The goal of our study is to report the immediate and long-term outcomes of patients with ≥ 70 % symptomatic intracranial atherosclerotic stenosis treated with balloon angioplasty and stent placement in a single centre. Patients and methods: This is a retrospective review of 37 consecutive patients with 42 procedures of ballon angioplasty and stenting for intracranial atherosclerotic stenosis (≥ 70 % stenosis) treated between 1999 and 2012. Technical success (residual stenosis ≤ 50 %), periprocedural success (no vascular complications within 72 hours), and long-term outcomes are reported. Results: Technical and periprocedural success was achieved in 90.5 % of patients. The within 72 hours periprocedural stroke/death rate was 7.1 % (4.8 % intracranial haemorrhage), and the 30-day stroke/death rate was 9.5 %. Thirty patients (81 %) had clinical follow-up at ≥ 6 months. During follow-up, 5 patients developed 6 ischemic events; 5 of them (17 %) were ipsilateral. The restenosis rate was 27 %, and the retreatment rate was 12 %. Conclusions: Our outcomes of the balloon angioplasty/stent placement for intracranial atherosclerotic stenosis are better than those in the SAMMPRIS study and compare favourably with those in large registries and observational studies.

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