Circadian Rhythm-Related Behavioral Disturbances and Structural Hypothalamic Changes in Alzheimer's Disease

1997 ◽  
Vol 8 (S3) ◽  
pp. 245-252 ◽  
Author(s):  
Witte J. G. Hoogendijk ◽  
Eus J. W. van Someren ◽  
Majid Mirmiran ◽  
Michel A. Hofman ◽  
Paul J. Lucassen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Circadian Rhythm ◽  
Older Persons ◽  
Behavioral Disturbances ◽  
Age Related ◽  
Wake Patterns ◽  
Nocturnal Restlessness ◽  
Mental Decline ◽  
Age Related Changes

Age-related changes in circadian rhythm (e.g., fragmented sleep-wake patterns) occur in many older persons but are particularly pronounced in patients with Alzheimer's disease. In these patients, disruptions of circadian rhythms can be severe enough to increase mental decline, agitation during the day, and restlessness at night. Moreover, patients whose nocturnal restlessness disrupts the sleep of the caregiver are more likely to be institutionalized than those who have cognitive impairment alone.

Neuroimaging Approaches for Elderly Studies

2017 ◽  
pp. 1576-1617
Author(s):  
Charis Styliadis ◽  
Panagiotis Kartsidis ◽  
Evangelos Paraskevopoulos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structure And Function ◽  
Cognitive Capacity ◽  
Aging Brain ◽  
Cerebral Structure ◽  
Age Related ◽  
Elderly Populations ◽  
And Function ◽  
Age Related Changes

Advances in the field of neuroimaging have allowed for the examination of the effects of age-related changes on cognitive capacity in elderly populations. Structural techniques are now routinely used to report cortical atrophic rates in aging and particularly within the context of the Alzheimer's disease, and may be integrated with functional techniques which examine the functional characteristics of the cortex at rest and during the performance of a task. Despite advancing age cognitive function remains highly plastic, allowing for interventions that aim to maintain or even remediate its capacity and the mechanisms by which structure and function are altered among seniors. Overall, information on the integrity of the cerebral structure and function aid in the early detection and treatment of the Alzheimer's disease as well as the evaluation and track of the disease's progression. In this chapter, neuroimaging methods are presented along with findings that are particularly relevant for the study of neuroplasticity in the aging brain.

The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults

Intelligence ◽  
2018 ◽  
Vol 70 ◽  
pp. 22-29 ◽  
Author(s):  
Karra D. Harrington ◽  
Christa Dang ◽  
Yen Ying Lim ◽  
David Ames ◽  
Simon M. Laws ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Preclinical Alzheimer’S Disease ◽  
Cognitively Normal ◽  
Age Related ◽  
Age Related Changes

P1-176 Age-related changes of Alzheimer's disease-associated protein in cynomolgus monkey brains

2004 ◽  
Vol 25 ◽  
pp. S145-S146
Author(s):  
Nobuyuki Kimura ◽  
Kentaro Tanemura ◽  
Shin-Ichiro Nakamura ◽  
Akihiko Takashima ◽  
Katsuhiko Yanagisawa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cynomolgus Monkey ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice

2012 ◽  
Vol 6 (1) ◽  
pp. 160-170 ◽  
Author(s):  
E. M. Knight ◽  
T. M. Brown ◽  
S. Gumusgoz ◽  
J. C. M. Smith ◽  
E. J. Waters ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Temperature ◽  
Core Body Temperature ◽  
Age Related ◽  
Core Body ◽  
Age Related Changes

P4-102: Age related changes in the default mode network are more advanced in Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S738-S738
Author(s):  
David Jones ◽  
Mary Machulda ◽  
Prashanthi Vemuri ◽  
Eric McDade ◽  
Guang Zeng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Default Mode ◽  
Age Related ◽  
Age Related Changes

Age-related changes in gene expression are accelerated in Alzheimer's disease

Synapse ◽  
2011 ◽  
Vol 65 (9) ◽  
pp. 971-974 ◽  
Author(s):  
P. Saetre ◽  
E. Jazin ◽  
L. Emilsson
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Age Related ◽  
Age Related Changes
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