Lean body mass is the strongest anthropometric predictor of left ventricular mass in the obese paediatric population

AbstractBackground:Indexing left ventricular mass to body surface area or height2.7 leads to inaccuracies in diagnosing left ventricular hypertrophy in obese children. Lean body mass predictive equations provide the opportunity to determine the utility of lean body mass in indexing left ventricular mass. Our objectives were to compare the diagnostic accuracy of predicted lean body mass, body surface area, and height in detecting abnormal left ventricle mass in obese children.Methods:Obese non-hypertensive patients aged 4–21 years were recruited prospectively. Dual-energy X-ray absorptiometry was used to measure lean body mass. Height, weight, sex, race, and body mass index z-score were used to calculate predicted lean body mass.Results:We enrolled 328 patients. Average age was 12.6 ± 3.8 years. Measured lean body mass had the strongest relationship with left ventricular mass (R2 = 0.84, p < 0.01) compared to predicted lean body mass (R2 = 0.82, p < 0.01), body surface area (R2 = 0.80, p < 0.01), and height2.7 (R2 = 0.65, p < 0.01). Of the clinically derived variables, predicted lean body mass was the only measure to have an independent association with left ventricular mass (β = 0.90, p < 0.01). Predicted lean body mass was the most accurate scaling variable in detecting left ventricular hypertrophy (positive predictive value = 88%, negative predictive value = 99%).Conclusions:Lean body mass is the strongest predictor of left ventricular mass in obese children. Predicted lean body mass is the most accurate anthropometric scaling variable for left ventricular mass in left ventricular hypertrophy detection. Predicted lean body mass should be considered for clinical use as the body size correcting variable for left ventricular mass in obese children.

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Left ventricular mass by echocardiographic measures in children and adolescents

Cardiology in the Young ◽

10.1017/s1047951112001862 ◽

2012 ◽

Vol 23 (5) ◽

pp. 727-737 ◽

Cited By ~ 2

Author(s):

Sudhir K. Mehta

Keyword(s):

Body Mass Index ◽

Children And Adolescents ◽

Surface Area ◽

Left Ventricular Mass ◽

Body Surface Area ◽

Body Mass ◽

Body Surface ◽

Left Ventricular ◽

Ventricular Mass ◽

Cardiovascular Morbidity And Mortality

AbstractBackgroundRecent evidence in adults suggests that left ventricular mass measured as left ventricular mass/height1.7 predicts cardiovascular morbidity and mortality better than the two widely used indices, left ventricular mass/body surface area and left ventricular mass/height2.7. Standards of left ventricular mass/height1.7 have not been reported in children, for whom, owing to lack of significant cardiovascular morbidity and mortality, body mass index has traditionally been used as a potential cardiovascular risk factor.MethodsIn this retrospective study, 692 clinically normal children aged 1 day to 18 years underwent detailed echocardiographic assessment to assess whether any of the left ventricular mass indices – left ventricular mass/height1.7, left ventricular mass/body surface area, and left ventricular mass/height2.7 – are associated with obesity as measured by body mass index. Correlations, t-tests, and linear regressions were used for statistical testing.ResultsLeft ventricular mass/height1.7 was better correlated (R2 = 0.36) with body mass index than left ventricular mass/body surface area (R2 = 0.179) and left ventricular mass/height2.7 (R2 = 0.006), although all three dependent variables show a significant correlation (p < 0.035). In addition, a higher percentage of obese patients were noted to have elevated left ventricular mass as measured by left ventricular mass/height1.7 than by the other two methods.ConclusionsLeft ventricular mass/height1.7 is a reliable indicator of obesity-associated left ventricular hypertrophy. Left ventricular mass/height1.7 can be used conveniently during transitions from youth to adults for long-term follow-up. These findings support the importance of including left ventricular mass/height1.7 in future studies of cardiovascular risks and preventive strategies in children and adolescents.

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The Prevalence of Left Ventricular Hypertrophy in Obese Children Varies Depending on the Method Utilized to Determine Left Ventricular Mass

Pediatric Cardiology ◽

10.1007/s00246-016-1380-0 ◽

2016 ◽

Vol 37 (6) ◽

pp. 993-1002 ◽

Cited By ~ 6

Author(s):

Joseph Mahgerefteh ◽

Jarrett Linder ◽

Ellen J. Silver ◽

Penelope Hazin ◽

Scott Ceresnak ◽

...

Keyword(s):

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Obese Children ◽

Ventricular Mass

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The association of ankle brachial index with left ventricular hypertrophy and left ventricular mass index: the Dong-gu study

VASA ◽

10.1024/0301-1526/a000289 ◽

2013 ◽

Vol 42 (4) ◽

pp. 284-291 ◽

Cited By ~ 1

Author(s):

Seong-Woo Choi ◽

Hye-Yeon Kim ◽

Hye-Ran Ahn ◽

Young-Hoon Lee ◽

Sun-Seog Kweon ◽

...

Keyword(s):

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Ankle Brachial Index ◽

Intima Media Thickness ◽

Left Ventricular ◽

Baseline Survey ◽

Ventricular Mass Index ◽

Ventricular Mass

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.

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ARTERIAL HYPERTENSION ASSOCIATED WITH HYPERURICEMIA: FEATURES OF HEART DAMAGE

Wiadomości Lekarskie ◽

10.36740/wlek202005119 ◽

2020 ◽

Vol 73 (5) ◽

pp. 943-946

Author(s):

Olha M. Chernatska ◽

Liudmyla N. Prystupa ◽

Hanna A. Fadieieva ◽

Alina V. Liashenko ◽

Yuliia O. Smiianova

Keyword(s):

Uric Acid ◽

Left Ventricular Hypertrophy ◽

Arterial Hypertension ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Serum Uric Acid Level ◽

Left Ventricular ◽

Ventricular Mass Index ◽

Ventricular Mass

The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) – arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation. We used clinical, anthropometric, biochemical, instrumental, statistical method. Serum uric acid level was observed by the reaction with uricase. Left ventricular mass index was calculated as left ventricular mass to body surface area ratio. The results were analyzed statistically by SPSS 21 and Graphpad. Results: Left ventricular mass index was significantly higher (р = 0,0498) in patients from the І group (109,7 ± 3,21) g/m2 comparable with the ІІ (97,6 ± 5,35) g/m2 and increased in proportion to the biggest level of uric acid (r = 0,31; p = 0,04) in patients with arterial hypertension and hyperuricemia. Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension.

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Association between oxygen delivery and left ventricular mass diastolic dysfunction in hypertensives with electrocardiographic left ventricular hypertrophy: the life study

American Journal of Hypertension ◽

10.1016/s0895-7061(01)01794-0 ◽

2001 ◽

Vol 14 (11) ◽

pp. A208

Author(s):

P Narayan

Keyword(s):

Left Ventricular Hypertrophy ◽

Diastolic Dysfunction ◽

Left Ventricular Mass ◽

Oxygen Delivery ◽

Ventricular Hypertrophy ◽

Left Ventricular ◽

Life Study ◽

Ventricular Mass

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A nutraceutical combination reduces left ventricular mass in subjects with metabolic syndrome and left ventricular hypertrophy: A multicenter, randomized, double-blind, placebo-controlled trial

Clinical Nutrition ◽

10.1016/j.clnu.2019.06.026 ◽

2020 ◽

Vol 39 (5) ◽

pp. 1379-1384 ◽

Cited By ~ 1

Author(s):

Valentina Mercurio ◽

Giacomo Pucci ◽

Giorgio Bosso ◽

Valeria Fazio ◽

Francesca Battista ◽

...

Keyword(s):

Metabolic Syndrome ◽

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Controlled Trial ◽

Left Ventricular ◽

Double Blind ◽

Double Blind Placebo ◽

Ventricular Mass

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Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia

Hypertension ◽

10.1161/hypertensionaha.120.14643 ◽

2020 ◽

Vol 76 (2) ◽

pp. 514-522 ◽

Cited By ~ 1

Author(s):

Coral Garcia-Gonzalez ◽

Georgios Georgiopoulos ◽

Samira Abdel Azim ◽

Fernando Macaya ◽

Nikos Kametas ◽

...

Keyword(s):

Surface Area ◽

Left Ventricular Mass ◽

Body Surface Area ◽

Risk Score ◽

Body Surface ◽

Left Ventricular ◽

Hazard Ratio ◽

Interquartile Range ◽

Ventricular Mass ◽

Cardiac Indices

Preeclampsia at term accounts for half of maternal deaths from hypertensive disorders. We aimed to assess differences in maternal cardiac indices at 35 +0 to 36 +6 weeks’ gestation between women who subsequently developed preeclampsia at term compared with those with uncomplicated pregnancy and to evaluate whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia. We recruited 1602 women with singleton pregnancies who attended for a routine hospital visit at 35 +0 to 36 +6 weeks’ gestation between April and November 2018. We recorded maternal characteristics and preeclampsia-risk-score derived from a competing risks model and measured cardiac indices. Preeclampsia developed in 3.12% (50/1602) of participants. Women with preeclampsia, compared with those without, had increased mean arterial pressure (97.6, SD, 5.53 versus 87.9, SD, 6.82 mm Hg), systemic vascular resistance (1500, interquartile range, 1393–1831 versus 1400, interquartile range, 1202–1630 PRU) and preeclampsia-risk-score (23.4, interquartile range, 9.13–40 versus 0.9, interquartile range, 0.32–3.25). Multivariable analysis demonstrated independent association between the incidence of preeclampsia and E/e′ (hazard ratio, 1.19/unit [95% CI, 1.03–1.37]; P =0.018) as well as left ventricular mass indexed for body surface area (hazard ratio, 1.03/[g·m 2 ] [95% CI, 1.003–1.051]; P =0.029). Women with E/e′ ≥7.3 and left ventricular mass indexed for body surface area ≥63.2 g/m 2 had an increased risk for developing preeclampsia, despite low preeclampsia-risk-score <5% (hazard ratio, 20.1 [95% CI, 10.5–38.7], P <0.001). Increased left ventricular mass and E/e′ offer incremental information to available scoring systems and better stratify women at risk of developing preeclampsia at term.

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