Premorbid intelligence estimation and level of dementia in Alzheimer's disease

1996 ◽  
Vol 2 (6) ◽  
pp. 551-555 ◽  
Author(s):  
A. Matt Maddrey ◽  
C.M. Cullum ◽  
M.F. Weiner ◽  
C.M. Filley
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Word Reading ◽  
Progressive Dementia ◽  
Sight Word Reading ◽  
Dementia Severity ◽  
Premorbid Intelligence ◽  
Adult Reading ◽  
Iq Scores ◽  
National Adult Reading Test

AbstractSimple sight-word reading tasks have demonstrated utility in the estimation of premorbid intelligence, although the effects of progressive dementia on such tasks has not been thoroughly examined. The present investigation sought to examine estimated IQ scores from the National Adult Reading Test-Revised (NART-R; Blair & Spreen, 1989) in relation to a WAlS-R-bascd (Wechsler, 1981) estimate of IQ in a series of patients with probable Alzheimer's disease across varying levels of dementia. Results suggest that while NART-R scores do show a decrement with dementia severity, this decline is mild, in contrast to traditionally based IQ scores and other measures of cognitive function, which show more marked declines. Similarly, compared with other tasks, the NART-R showed the strongest correlation with education across the sample as a whole, while the other indices were more related to level of dementia. These findings support the use of measures such as the NART-R in estimating premorbid intellectual functioning in patients at various levels of dementia severity, including those with more advanced cognitive deterioration. (JINS, 1996, 2, 551–555.)

Further Evidence that Reading Ability is not Preserved in Alzheimer's Disease

1995 ◽  
Vol 167 (5) ◽  
pp. 659-662 ◽  
Author(s):  
R. E. O'Carroll ◽  
N. Prentice ◽  
C. Murray ◽  
M. Van Beck ◽  
K. P. Ebmeier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Reading Ability ◽  
Disease Process ◽  
Total Sample ◽  
Regression Equations ◽  
Full Time ◽  
Dementia Severity ◽  
Adult Reading ◽  
National Adult Reading Test

BackgroundPre-morbid intelligence level is routinely assessed in Alzheimer's disease using the National Adult Reading Test (NART). This practice is based on the assumption that pronunciation of irregular words remains unaffected by the disease process. Recent reports have suggested that reading ability may become compromised in moderately demented subjects.MethodSixty-eight probable Alzheimer patients were classified into stages of severity (minimal, mild and moderate) using the Mini-Mental State Examination (MMSE). NART and demographic equations were used to estimate pre-morbid ability.ResultsA significant correlation emerged between dementia severity and reading ability, NART v. MMSE scores, r = 0.46, P < 0.01. When the total sample was subdivided into moderate, mild and minimal subgroups, significant between-group differences emerged, despite the groups being well matched for age, sex, and years of full-time education. Pre-morbid IQ, as estimated by demographic regression equations, did not correlate with dementia severity.ConclusionNART performance is compromised in moderate Alzheimer disease, and the measure provides a serious underestimate of pre-morbid IQ in patients with an MMSE of 13 or less.

A longitudinal study of reading ability in patients suffering from dementia

1995 ◽  
Vol 1 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Louise Paque ◽  
Elizabeth K. Warrington
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Reading Ability ◽  
Intellectual Functioning ◽  
Reading Test ◽  
Verbal Iq ◽  
Adult Reading ◽  
National Adult Reading Test ◽  
Over Time

AbstractThe aim of this study was to investigate whether reading is a preserved ability in patients suffering from dementia, as was first suggested by Nelson and McKenna (1975). The 57 patients included in the study had possible or probable Alzheimer's disease or similar degenerative conditions and were assessed longitudinally. Their performance on the National Adult Reading Test [(NART); Nelson, 1982, 1991] is compared to that on a shortened version of the WAIS-R. It is found that although performance on the NART does decline gradually over time, the deterioration on formal tests of IQ is more rapid and more severe. It seems that the decline in reading across the group is due to those patients who have a lower verbal IQ (VIQ) than performance IQ (PIQ). It is concluded that generally the NART can be used as a predictor of the premorbid intellectual functioning of a patient with dementia, given that the VIQ is greater than PIQ. (JINS, 1995, 1, 517–524.)

scholarly journals Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease

2000 ◽  
Vol 10 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Eric Salmon ◽  
Fabienne Collette ◽  
Christian Degueldre ◽  
Christian Lemaire ◽  
Georges Franck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Metabolism ◽  
Dementia Severity

Estimation of Premorbid Intelligence in Schizophrenia

1992 ◽  
Vol 161 (1) ◽  
pp. 69-74 ◽  
Author(s):  
J. R. Crawford ◽  
J. A. O. Besson ◽  
M. Bremner ◽  
K. P. Ebmeier ◽  
R. H. B. Cochrane ◽  
...  
Keyword(s):  
Alternative Explanation ◽  
Adult Intelligence Scale ◽  
Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Premorbid Intelligence ◽  
Schizophrenic Patients ◽  
Adult Reading ◽  
Valid Estimate ◽  
Wechsler Adult Intelligence ◽  
National Adult Reading Test

To determine whether the National Adult Reading Test (NART) would provide a valid estimate of premorbid intelligence in schizophrenia, two schizophrenic samples were recruited, one consisting of 35 patients resident in long-stay wards, the other of 29 patients normally resident in the community. Schizophrenic patients were individually matched for age, sex, and education with a healthy, normal subject. Both schizophrenic samples scored significantly lower on the Wechsler Adult Intelligence Scale (WAIS) than their respective control groups. NART-estimated IQ did not differ significantly between the community-resident schizophrenics and their controls, suggesting that the NART provides a valid means of estimating premorbid intelligence in such a population. NART-estimated IQ was significantly lower in the long-stay sample than in their controls. Although low NART scores in this latter sample could be a valid reflection of low premorbid IQ, the alternative explanation that NART performance was impaired by onset of the disease cannot be ruled out.

scholarly journals Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer’s Disease Biomarkers

2015 ◽  
Vol 50 (1) ◽  
pp. 249-260 ◽  
Author(s):  
Anna Malishkevich ◽  
Gad A. Marshall ◽  
Aaron P. Schultz ◽  
Reisa A. Sperling ◽  
Judith Aharon-Peretz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Stage ◽  
Disease Biomarkers ◽  
Premorbid Intelligence ◽  
Activity Dependent
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