Effects of High-Definition Transcranial Direct Current Stimulation and Theta Burst Stimulation for Modulating the Posterior Parietal Cortex

2019 ◽  
Vol 25 (09) ◽  
pp. 972-984
Author(s):  
Tian Gan ◽  
Stevan Nikolin ◽  
Colleen K. Loo ◽  
Donel M. Martin
Keyword(s):  
Working Memory ◽  
Parietal Cortex ◽  
Direct Current ◽  
Posterior Parietal Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
High Definition ◽  
Attention Task ◽  
Posterior Parietal ◽  
Theta Burst

AbstractObjectives:Noninvasive brain stimulation methods, including high-definition transcranial direct current stimulation (HD-tDCS) and theta burst stimulation (TBS) have emerged as novel tools to modulate and explore brain function. However, the relative efficacy of these newer stimulation approaches for modulating cognitive functioning remains unclear. This study investigated the cognitive effects of HD-tDCS, intermittent TBS (iTBS) and prolonged continuous TBS (ProcTBS) and explored the potential of these approaches for modulating hypothesized functions of the left posterior parietal cortex (PPC).Methods:Twenty-two healthy volunteers attended four experimental sessions in a cross-over experimental design. In each session, participants either received HD-tDCS, iTBS, ProcTBS or sham, and completed cognitive tasks, including a divided attention task, a working memory maintenance task and an attention task (emotional Stroop test).Results:The results showed that compared to sham, HD-tDCS, iTBS and ProcTBS caused significantly faster response times on the emotional Stroop task. The effect size (Cohen’sd) wasd= .32 for iTBS (p< .001), .21 for ProcTBS (p= .01) and .15 for HD-tDCS (p= .044). However, for the performance on the divided attention and working memory maintenance tasks, no significant effect of stimulation was found.Conclusions:The results suggest that repetitive transcranial magnetic stimulation techniques, including TBS, may have greater efficacy for modulating cognition compared with HD-tDCS, and extend existing knowledge about specific functions of the left PPC.

P2. Theta burst stimulation over left posterior parietal cortex interferes with imitation of gestures

2012 ◽  
Vol 123 (10) ◽  
pp. e101-e102
Author(s):  
Tim Vanbellingen ◽  
Manuel Bertschi ◽  
Thomas Nyffeler ◽  
Dario Cazzoli ◽  
Roland Wiest ◽  
...  
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Left Posterior ◽  
Posterior Parietal ◽  
Theta Burst

Anodal High-definition Transcranial Direct Current Stimulation over the Posterior Parietal Cortex Modulates Approximate Mental Arithmetic

2020 ◽  
Vol 32 (5) ◽  
pp. 862-876
Author(s):  
Matthias Hartmann ◽  
Sarah Singer ◽  
Branislav Savic ◽  
René M. Müri ◽  
Fred W. Mast
Keyword(s):  
Parietal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Posterior Parietal Cortex ◽  
Mental Arithmetic ◽  
Cognitive Capacity ◽  
High Definition ◽  
Direct Current Stimulation ◽  
Posterior Parietal ◽  
Left And Right

The representation and processing of numerosity is a crucial cognitive capacity. Converging evidence points to the posterior parietal cortex (PPC) as primary “number” region. However, the exact role of the left and right PPC for different types of numerical and arithmetic tasks remains controversial. In this study, we used high-definition transcranial direct current stimulation (HD-tDCS) to further investigate the causal involvement of the PPC during approximative, nonsymbolic mental arithmetic. Eighteen healthy participants received three sessions of anodal HD-tDCS at 1-week intervals in counterbalanced order: left PPC, right PPC, and sham stimulation. Results showed an improved performance during online parietal HD-tDCS (vs. sham) for subtraction problems. Specifically, the general tendency to underestimate the results of subtraction problems (i.e., the “operational momentum effect”) was reduced during online parietal HD-tDCS. There was no difference between left and right stimulation. This study thus provides new evidence for a causal involvement of the left and right PPC for approximate nonsymbolic arithmetic and advances the promising use of noninvasive brain stimulation in increasing cognitive functions.

scholarly journals Preconditioning with Cathodal High-Definition Transcranial Direct Current Stimulation Sensitizes the Primary Motor Cortex to Subsequent Intermittent Theta Burst Stimulation

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wenjun Dai ◽  
Yao Geng ◽  
Hao Liu ◽  
Chuan Guo ◽  
Wenxiang Chen ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Long Term Potentiation ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
High Definition ◽  
Term Potentiation ◽  
Theta Burst

Noninvasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) can induce long-term potentiation-like facilitation, but whether the combination of TMS and tDCS has additive effects is unclear. To address this issue, in this randomized crossover study, we investigated the effect of preconditioning with cathodal high-definition (HD) tDCS on intermittent theta burst stimulation- (iTBS-) induced plasticity in the left motor cortex. A total of 24 healthy volunteers received preconditioning with cathodal HD-tDCS or sham intervention prior to iTBS in a random order with a washout period of 1 week. The amplitude of motor evoked potentials (MEPs) was measured at baseline and at several time points (5, 10, 15, and 30 min) after iTBS to determine the effects of the intervention on cortical plasticity. Preconditioning with cathodal HD-tDCS followed by iTBS showed a greater increase in MEP amplitude than sham cathodal HD-tDCS preconditioning and iTBS at each time postintervention point, with longer-lasting after-effects on cortical excitability. These results demonstrate that preintervention with cathodal HD-tDCS primes the motor cortex for long-term potentiation induced by iTBS and is a potential strategy for improving the clinical outcome to guide therapeutic decisions.

scholarly journals Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lara Merken ◽  
Marco Davare ◽  
Peter Janssen ◽  
Maria C. Romero
Keyword(s):  
Parietal Cortex ◽  
High Intensity ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Primate Model ◽  
Power Grip ◽  
Fitts Law ◽  
Behavioral Evidence ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

AbstractThe neural mechanisms underlying the effects of continuous Theta-Burst Stimulation (cTBS) in humans are poorly understood. Animal studies can clarify the effects of cTBS on individual neurons, but behavioral evidence is necessary to demonstrate the validity of the animal model. We investigated the behavioral effect of cTBS applied over parietal cortex in rhesus monkeys performing a visually-guided grasping task with two differently sized objects, which required either a power grip or a pad-to-side grip. We used Fitts’ law, predicting shorter grasping times (GT) for large compared to small objects, to investigate cTBS effects on two different grip types. cTBS induced long-lasting object-specific and dose-dependent changes in GT that remained present for up to two hours. High-intensity cTBS increased GTs for a power grip, but shortened GTs for a pad-to-side grip. Thus, high-intensity stimulation strongly reduced the natural GT difference between objects (i.e. the Fitts’ law effect). In contrast, low-intensity cTBS induced the opposite effects on GT. Modifying the coil orientation from the standard 45-degree to a 30-degree angle induced opposite cTBS effects on GT. These findings represent behavioral evidence for the validity of the nonhuman primate model to study the neural underpinnings of non-invasive brain stimulation.

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