Neural Correlates of Familiar and Unfamiliar Action in Infancy

Behavioral evidence shows that experience with an action shapes action perception. Neural mirroring has been suggested as a mechanism underlying this behavioral phenomenon. Suppression of EEG power in the mu frequency band, an index of motor activation, typically reflects neural mirroring. However, contradictory findings exist regarding the association between mu suppression and motor familiarity in infant EEG studies. In this study, we investigated the neural underpinnings reflecting the role of familiarity on action perception. We measured neural processing of familiar (grasp) and novel (tool-use) actions in 9-and-12-month-old infants. Specifically, we measured infants’ distinct motor/visual activity and explored functional connectivity associated with these processes. Mu suppression was stronger for grasping than tool-use, while significant mu and occipital alpha (indexing visual activity) suppression were evident for both actions. Interestingly, selective visual-motor functional connectivity was found during observation of familiar action, a pattern not observed for novel action. Thus, the neural correlates of perception of familiar actions may be best understood in terms of a functional neural network, rather than isolated regional activity.Our findings provide novel insights on analytic approaches for identifying motor-specific neural activity while also considering neural networks involved in observing motorically familiar versus actions.

Behavioral evidence for nested central pattern generator control of Drosophila grooming

Central pattern generators (CPGs) are neurons or neural circuits that produce periodic output without requiring patterned input. More complex behaviors can be assembled from simpler subroutines, and nested CPGs have been proposed to coordinate their repetitive elements, organizing control over different time scales. Here, we use behavioral experiments to establish that Drosophila grooming may be controlled by nested CPGs. On a short time scale (5–7 Hz, ~ 200 ms/movement), flies clean with periodic leg sweeps and rubs. More surprisingly, transitions between bouts of head sweeping and leg rubbing are also periodic on a longer time scale (0.3–0.6 Hz, ~2 s/bout). We examine grooming at a range of temperatures to show that the frequencies of both oscillations increase—a hallmark of CPG control—and also that rhythms at the two time scales increase at the same rate, indicating that the nested CPGs may be linked. This relationship holds when sensory drive is held constant using optogenetic activation, but oscillations can decouple in spontaneously grooming flies, showing that alternative control modes are possible. Loss of sensory feedback does not disrupt periodicity but slow down the longer time scale alternation. Nested CPGs simplify the generation of complex but repetitive behaviors, and identifying them in Drosophila grooming presents an opportunity to map the neural circuits that constitute them.

Investigating Mindful Awareness from Moment-to-Moment in Meditation: The Mindful Awareness Task (MAT)

Buddhist and contemporary psychological theories propose that training attention and awareness in mindfulness meditation is a fundamental mechanism of mindfulness, essential for producing its salutary effects. Yet, the empirical foundation for this central idea in mindfulness science is surprisingly small due to a limited methodological capacity to measure attention and awareness during mindfulness meditation. Accordingly, we set out to study these processes (N = 143) via a novel behavioral paradigm measuring the objects and temporal dynamics of mindful awareness during meditation – the Mindful Awareness Task (MAT). Using this paradigm, we empirically characterized attention and awareness during mindfulness meditation. We provide novel behavioral evidence indicating that, as long-theorized, attention and awareness during mindfulness meditation are related to previous mindfulness meditation practice, attitudinal qualities of mindfulness, attention regulation, and mental health. We found that in contrast to widely held assumptions, sustained attention and executive functions, as measured via common cognitive-experimental tasks, may not be meaningfully related to the cognitive capacities trained and expressed in mindfulness meditation. Furthermore, we found that the accuracy of self-reported mindfulness is, paradoxically, dependent on behaviorally measured capacities for mindful awareness. Collectively, our behavioral findings reveal that, as long-theorized, attention and awareness during mindfulness meditation may indeed be fundamental to the practice, cultivation, and salutary functions of mindfulness. Findings indicate that the MAT paradigm may overcome significant limitations of extant measurement methods, and thereby enable future scientific insights into attention and awareness in mindfulness meditation and their salutary effects.

Olfactory sensory preconditioning in Drosophila: role of memory forgetting in gating S1/S2 associations

Learning and memory storage is a complex process that has proven challenging to tackle. It is likely that, in real nature, the instructive value of reinforcing experiences is acquired rather than innate. The association between seemingly neutral stimuli increases the gamut of possibilities to create meaningful associations and increases the predictive power of moment-by-moment experiences. Here we report physiological and behavioral evidence of olfactory unimodal sensory preconditioning in fruit flies. We show that the presentation of a pair of odors (S1 and S2) before one of them (S1) is associated with electric shocks elicits a conditional response not only to the trained odor (S1) but to the odor previously paired with it (S2). This occurs even if the S2 odor was never presented in contiguity with the aversive stimulus. In addition, we show that inhibition of the small G protein and known forgetting regulator Rac1 facilitates the association between S1/S2 odors. These results indicate that flies can infer value to non-paired odor based on the previous associative structure between odors, and inhibition of Rac1 lengthens the time of olfactory sensory buffer, allowing linking of neutral odors presented in sequence.

EXPRESS: Behavioral evidence of altered sensory attenuation in obesity

Body ownership (i.e., the conscious belief of owning a body) and sense of agency (i.e., being the agent of one’s own movements) are part of a pre-reflective experience of bodily self, which grounds on low-level complex sensory–motor processes. While previous literature had already investigated body ownership in obesity, sense of agency was never explored. Here, we exploited the sensory attenuation effect (i.e., an implicit marker of the sense of agency; SA effect) to investigate whether the sense of agency was altered in a sample of eighteen individuals affected by obesity as compared with eighteen healthy-weight individuals. In our experiment, participants were asked to rate the perceived intensity of self-generated and other-generated tactile stimuli. Healthy-weight individuals showed a significantly greater SA effect than participants affected by obesity. Indeed, while healthy-weight participants perceived self-generated stimuli as significantly less intense as compared to externally generated ones, this difference between stimuli was not reported by affected participants. Our results relative to the SA effect pinpointed an altered sense of agency in obesity. We discussed this finding within the motor control framework with reference to obesity. We encouraged future research to further explore such effect and its role in shaping the clinical features of obesity.

Reward Rapidly Enhances Visual Perception

Rewards exert a deep influence on our cognition and behavior. Here, we used a paradigm in which reward information was provided at either encoding or retrieval of a brief, masked stimulus to show that reward can also rapidly modulate perceptual encoding of visual information. Experiment 1 ( n = 30 adults) showed that participants’ response accuracy was enhanced when a to-be-encoded grating signaled high reward relative to low reward, but only when the grating was presented very briefly and participants reported that they were not consciously aware of it. Experiment 2 ( n = 29 adults) showed that there was no difference in participants’ response accuracy when reward information was instead provided at the stage of retrieval, ruling out an explanation of the reward-modulation effect in terms of differences in motivated retrieval. Taken together, our findings provide behavioral evidence consistent with a rapid reward modulation of visual perception, which may not require consciousness.

Land Value Taxation: A Spatially Explicit Economic Experiment with Endogenous Institutions

An economic experiment with endogenous institutions informs the political economy of land value taxation relative to uniform property taxation in terms of efficiency and sprawl reduction. Heterogeneous type distributions were used so that land value taxation was earnings-rational, relative to uniform property taxation, for 40, 60, and 80 percent of the participants. The model’s induced values predict land value taxation leads to less sprawl, more earnings, and more tax revenue than uniform property taxation. Experimental data do not consistently match this prediction, where both tax institutions led to more sprawl and lower earnings than predicted. Results show participants voted for the tax institution that does not maximize their individual earnings in 16.7 percent of rounds. These earnings-irrational choices occurred when the type distributions were 40 and 60 percent in favor of land value taxation. The experiment results nonetheless show the absolute advantage of land value taxation for producing less sprawl, more tax revenue, and more earnings. Moreover, the behavioral evidence suggests that relative advantage of land value taxation in reducing sprawl is greater than predicted by the model. This suggests further inquiry about whether land value taxation promotion activities may best be targeted towards cities using uniform property taxation where economies are vibrant, land uses are already relatively intensive, and greater-than-average population density already exists.

Long-term priors influence visual perception through recruitment of long-range feedback

Perception results from the interplay of sensory input and prior knowledge. Despite behavioral evidence that long-term priors powerfully shape perception, the neural mechanisms underlying these interactions remain poorly understood. We obtained direct cortical recordings in neurosurgical patients as they viewed ambiguous images that elicit constant perceptual switching. We observe top-down influences from the temporal to occipital cortex, during the preferred percept that is congruent with the long-term prior. By contrast, stronger feedforward drive is observed during the non-preferred percept, consistent with a prediction error signal. A computational model based on hierarchical predictive coding and attractor networks reproduces all key experimental findings. These results suggest a pattern of large-scale information flow change underlying long-term priors’ influence on perception and provide constraints on theories about long-term priors’ influence on perception.

Evidence for effective conservation fundraising: Comparing social media with traditional mailshot field experiments

Funding shortage limits conservation impact, making it vital to find effective fundraising methods. To explore how traditional and digital conservation fundraising methods perform, we conducted real-world field experiments by using mailshot and Facebook advertisements. We compare three types of message frames (Simple, Seed money, and Ecological) and found that the Seed money frame, which emphasizes the amount already donated, increased the number of donors, whereas the Ecological frame, which focuses on the fact that the fundraiser benefits threatened species, led to a relative reduction in this number. We also found that while on Facebook advertising costs were higher than donations, the opposite was true for the traditional mailshot experiment. Our findings illustrate some of the challenges associated with online fundraising, and importance of behavioral evidence to enhance effective fundraising in conservation.