scholarly journals Long-term dietary flavonoid intake and change in cognitive function in the Framingham Offspring cohort – ERRATUM

2020 ◽  
Vol 23 (13) ◽  
pp. 2455-2455
Author(s):  
Esra Shishtar ◽  
Gail T Rogers ◽  
Jeffrey B Blumberg ◽  
Rhoda Au ◽  
Paul F Jacques
Keyword(s):  
Cognitive Function ◽  
Offspring Cohort ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

scholarly journals Long-term dietary flavonoid intake and change in cognitive function in the Framingham Offspring cohort

2020 ◽  
Vol 23 (9) ◽  
pp. 1576-1588 ◽  
Author(s):  
Esra Shishtar ◽  
Gail T Rogers ◽  
Jeffrey B Blumberg ◽  
Rhoda Au ◽  
Paul F Jacques
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Visual Memory ◽  
Verbal Learning ◽  
Cognitive Domain ◽  
Offspring Cohort ◽  
Global Function ◽  
Flavonoid Intake

AbstractObjective:To examine the association between long-term intake of total and the six classes of dietary flavonoids and decline in cognitive function over a follow-up period of up to 15 years.Design:In this longitudinal study, we evaluated change in eight cognitive domain scores (verbal and visual memory, verbal learning, attention and concentration, abstract reasoning, language, visuoperceptual organisation and the global function) based on three neuropsychological exams and characterised the annualised change between consecutive exams. Long-term intakes of total and six flavonoid classes were assessed up to four times by a validated FFQ. Repeated-measures regression models were used to examine the longitudinal association between total and six flavonoid classes and annualised change in the eight cognitive domains.Setting:The Framingham Heart Study (FHS), a prospective cohort study.Participants:One thousand seven hundred and seventy-nine subjects who were free of dementia, aged ≥45 years and had attended at least two of the last three FHS Offspring cohort study exams.Results:Over a median follow-up of 11·8 years with 1779 participants, nominally significant trends towards a slower decline in cognitive function were observed among those with higher flavanol and flavan-3-ol intakes for global function, verbal and visual memory; higher total flavonoids and flavonoid polymers for visual memory; and higher flavanols for verbal learning.Conclusions:In spite of modest nominal trends, overall, our findings do not support a clear association between higher long-term flavonoid intake and slowing age-related cognitive decline.

scholarly journals Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort

2020 ◽  
Vol 112 (2) ◽  
pp. 343-353 ◽  
Author(s):  
Esra Shishtar ◽  
Gail T Rogers ◽  
Jeffrey B Blumberg ◽  
Rhoda Au ◽  
Paul F Jacques
Keyword(s):  
Alzheimer Disease ◽  
Observational Studies ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Dietary Intakes ◽  
Offspring Cohort ◽  
Flavonoid Intake ◽  
Nonlinear Relation ◽  
Dietary Flavonoid

ABSTRACT Background Findings from existing prospective observational studies on the protective associations of flavonoid intake and the risk of Alzheimer disease and related dementias (ADRD) are inconsistent largely due to limitations of these studies. Objectives To examine the prospective relation between total and 6 classes of dietary flavonoid intake and risk of ADRD and Alzheimer disease (AD) while addressing limitations of earlier observational studies. Methods We used data from the Framingham Heart Study Offspring Cohort exams 5 through 9. Participants were ADRD-free with a valid FFQ at baseline. Flavonoid intakes were updated at each exam to represent the cumulative average intake across the 5 exams, and were expressed as percentile categories of intake (≤15th, >15th to 30th, >30th to 60th, >60th) to handle their nonlinear relation with ADRD and AD. Cox proportional hazards regression was used to estimate the HRs for the association between the flavonoid intakes and incidence of ADRD and AD. Results Over an average follow-up of 19.7 y in 2801 participants (mean baseline age = 59.1 y; 52% females), there were 193 ADRD events of which 158 were AD. After multivariate and dietary adjustments, individuals with the highest (>60th percentile) intakes of flavonols, anthocyanins, and flavonoid polymers had a lower risk of ADRD relative to individuals with the lowest intakes (≤15th percentile), with HRs (95% CI; P-trend) of 0.54 (0.32, 0.90; P = 0.003) for flavonols, 0.24 (0.15, 0.39; P < 0.001) for anthocyanins, and 0.58 (0.35, 0.94; P = 0.03) for flavonoid polymers. The same pattern of associations was seen with AD for flavonols and anthocyanins but not for flavonoid polymers. Conclusions Our findings imply that higher long-term dietary intakes of flavonoids are associated with lower risks of ADRD and AD in US adults.

Author Response: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women

Neurology ◽  
2021 ◽  
Vol 97 (23) ◽  
pp. 1095-1095
Author(s):  
Tian-Shin Yeh ◽  
Changzheng Yuan ◽  
Alberto Ascherio ◽  
Bernard A. Rosner ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Author Response ◽  
Subjective Cognitive Decline ◽  
Men And Women ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

scholarly journals A Prospective Study of Dietary Flavonoid Intake and Risk of Glioma in US Men and Women

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 263-263
Author(s):  
Alaina Bever ◽  
Aedin Cassidy ◽  
Eric Rimm ◽  
Meir Stampfer ◽  
David Cote
Keyword(s):  
Total Flavonoid ◽  
Health Study ◽  
Men And Women ◽  
Funding Sources ◽  
Flavonoid Intake ◽  
Glioma Risk ◽  
Dietary Flavonoid ◽  
Incident Cases

Abstract Objectives Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease glioma risk, an association that has not yet been investigated in humans. The objective of this study was to evaluate the association between dietary flavonoid consumption and glioma risk in participants in the female Nurses’ Health Study (1984–2014, n = 81,688) and Nurses’ Health Study II (1991–2017, n = 95,228), and the male Health Professionals Follow-up Study (1986–2014, n = 49,884). Methods Exposure was average long-term (up to 30 years) and recent (up to 12 years) intake of total flavonoids and six flavonoid subclasses, derived from validated quadrennial food frequency questionnaires. The primary outcome was incident glioma, confirmed by medical record review. Results We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymer intake was associated with decreased glioma risk in pooled analyses comparing highest to lowest quintile of consumption (total flavonoid hazard ratio (HR) = 0.79, 95% CI: 0.59–1.05, P-trend = 0.04; flavan-3-ol HR = 0.76, 95% CI: 0.57–1.01, P-trend = 0.04; polymer HR = 0.82, 95% CI: 0.61–1.09, P-trend = 0.05). Associations with recent intake were weaker and not statistically significant. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there was no significant association between flavan-3-ol or polymer consumption and glioma. Conclusions Increased dietary intake of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, was associated with decreased glioma risk in a prospective cohort of men and women. Habitual consumption of foods and beverages containing flavan-3-ols and polymeric flavonoids may protect against the development of glioma. Funding Sources This work was supported by the U.S. National Institutes of Health.

scholarly journals Flavonoid Intake and MRI Markers of Brain Health in the Framingham Offspring Cohort

2020 ◽  
Vol 150 (6) ◽  
pp. 1545-1553
Author(s):  
Esra Shishtar ◽  
Gail T Rogers ◽  
Jeffrey B Blumberg ◽  
Rhoda Au ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Hippocampal Volume ◽  
Offspring Cohort ◽  
Linear Regression Models ◽  
Brain Health ◽  
Cross Sectional ◽  
Heart Study ◽  
Total Brain ◽  
Flavonoid Intake ◽  
The Mean ◽  
Dietary Flavonoid

ABSTRACT Background Although greater flavonoid intake is associated with a reduced risk of Alzheimer's disease (AD) and related dementias (ADRD), evidence relating dietary flavonoid intake to brain health based on MRI is lacking. Objective The objective of this study was to explore the association between dietary flavonoid intake and MRI measures of brain health, including total brain tissue volume (TBV), white matter hyperintensities volume (WMHV), and hippocampal volume (HV). Methods Eligible subjects included members of the Framingham Heart Study Offspring Cohort who were free of stroke at exam 7 and had at least 1 valid food frequency questionnaire from exams 5, 6, or 7 (n = 2086; mean age at exam 7, 60.6 y). Flavonoid intakes represented the cumulative mean of intakes across the 3 exams and were categorized based on quartiles categories of intake. TBV, WMHV, and HV were assessed at exam 7. Multiple linear regression models were used to examine the cross-sectional association between total and the 6 classes of flavonoids and the 3 aforementioned MRI measures. Results The mean (95% CI) of the WMHV of subjects in the highest quartile category of flavan-3-ols [0.56 (0.52, 0.61)] and flavonoid polymers [0.57 (0.52, 0.61)] intake was significantly smaller relative to that of subjects in the lowest quartile category of flavan-3-ols [0.65 (0.60, 0.71)] and flavonoid polymers [0.66 (0.60, 0.71)] after accounting for important demographic, lifestyle, and clinical factors. Inverse trend associations with WMHV were also seen for flavan-3-ols (P = 0.01) and flavonoid polymers (P = 0.01) as well as for total flavonoids (P = 0.01). TBV and HV were not associated with dietary flavonoid intake following the adjustment for potential confounders. Conclusions Our results contribute to the literature on flavonoids and ADRD as they suggest that higher flavonoid intakes may affect ADRD risk in middle-aged and older adults by reducing WMHV, a marker strongly associated with ADRD.

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